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Human Coronavirus-NL63 infections in Korean children, 2004-2006.
J Clin Virol. 2007 Jan; 38(1):27-31.JC

Abstract

BACKGROUND

Human coronavirus-NL63 (HCoV-NL63) has been isolated from children with respiratory tract infections and its prevalence in Korea has not been reported.

OBJECTIVES

This study was designed to investigate the presence and the clinical features of HCoV-NL63 during two winter seasons.

STUDY DESIGN

During April 2004-April 2006, nasopharyngeal specimens from children hospitalized with acute respiratory disease were tested for common respiratory viruses, including RSV, influenza A, influenza B, parainfluenza viruses, and adenovirus by IFA. hMPV infection was excluded by nested RT-PCR using primers for F-gene. To detect HCoV-NL63, previously described nested PCR assays for 1a and 1b were used. PCR products of the 1a gene for HCoV-NL63 were sequenced.

RESULTS

Out of 872 nasopharyngeal aspirate from children aged under 16 years, 14 (1.7%) were positive for HCoV-NL63. Most of the patients had croup (64.2%) or bronchiolitis (21.4%). The peak prevalence was found in November (28.5%). Most were collected between November 2004 and February 2005.

CONCLUSIONS

HCoV-NL63 may be one of the causative agents of acute respiratory tract infection, especially croup.

Authors+Show Affiliations

Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17137835

Citation

Han, Tae Hee, et al. "Human Coronavirus-NL63 Infections in Korean Children, 2004-2006." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 38, no. 1, 2007, pp. 27-31.
Han TH, Chung JY, Kim SW, et al. Human Coronavirus-NL63 infections in Korean children, 2004-2006. J Clin Virol. 2007;38(1):27-31.
Han, T. H., Chung, J. Y., Kim, S. W., & Hwang, E. S. (2007). Human Coronavirus-NL63 infections in Korean children, 2004-2006. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 38(1), 27-31.
Han TH, et al. Human Coronavirus-NL63 Infections in Korean Children, 2004-2006. J Clin Virol. 2007;38(1):27-31. PubMed PMID: 17137835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human Coronavirus-NL63 infections in Korean children, 2004-2006. AU - Han,Tae Hee, AU - Chung,Ju-Young, AU - Kim,Sang Woo, AU - Hwang,Eung-Soo, Y1 - 2006/11/29/ PY - 2006/05/30/received PY - 2006/10/09/revised PY - 2006/10/19/accepted PY - 2006/12/2/pubmed PY - 2007/3/3/medline PY - 2006/12/2/entrez SP - 27 EP - 31 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 38 IS - 1 N2 - BACKGROUND: Human coronavirus-NL63 (HCoV-NL63) has been isolated from children with respiratory tract infections and its prevalence in Korea has not been reported. OBJECTIVES: This study was designed to investigate the presence and the clinical features of HCoV-NL63 during two winter seasons. STUDY DESIGN: During April 2004-April 2006, nasopharyngeal specimens from children hospitalized with acute respiratory disease were tested for common respiratory viruses, including RSV, influenza A, influenza B, parainfluenza viruses, and adenovirus by IFA. hMPV infection was excluded by nested RT-PCR using primers for F-gene. To detect HCoV-NL63, previously described nested PCR assays for 1a and 1b were used. PCR products of the 1a gene for HCoV-NL63 were sequenced. RESULTS: Out of 872 nasopharyngeal aspirate from children aged under 16 years, 14 (1.7%) were positive for HCoV-NL63. Most of the patients had croup (64.2%) or bronchiolitis (21.4%). The peak prevalence was found in November (28.5%). Most were collected between November 2004 and February 2005. CONCLUSIONS: HCoV-NL63 may be one of the causative agents of acute respiratory tract infection, especially croup. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/17137835/Human_Coronavirus_NL63_infections_in_Korean_children_2004_2006_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(06)00407-0 DB - PRIME DP - Unbound Medicine ER -