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Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden.

Abstract

The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the incidence of objectively diagnosed first episodes of VTE was assessed in 553 first-degree relatives of 161 patients with acute VTE and FVL. The annual incidence of VTE was 0.43% (95% CI, 0.3 to 0.56) with FVL and 0.17% (95% CI, 0.07 to 0.27) without FVL (relative risk of 2.5,95% CI, 1.3 to 4.7). A majority (70%) of episodes of VTE were provoked, and this proportion was similar with and without FVL. A larger proportion of VTE was provoked in women (83%) that in men (33%), with the difference accounted for by pregnancy and use of oral contraceptives. The proportion of pregnancies complicated by VTE was 3.9% (95% CI, 2.0-5.8) with FVL and 1.4% (95% CI, 0.04-2.7) without FVL. FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE.

Authors+Show Affiliations

,

GETBO, EA 3878, Department of Internal Medicine and Chest Diseases, University Hospital Centre La Cavale Blanche, 29609 Brest, Cedex, France. francis.couturaud@chu-brest.fr

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Source

Thrombosis and haemostasis 96:6 2006 Dec pg 744-9

MeSH

Adolescent
Adult
Age Distribution
Age Factors
Aged
Aging
Cohort Studies
Contraceptives, Oral
Factor V
Female
France
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Male
Middle Aged
Pedigree
Pregnancy
Pregnancy Complications, Cardiovascular
Proportional Hazards Models
Prospective Studies
Pulmonary Embolism
Recurrence
Retrospective Studies
Risk Assessment
Risk Factors
Sex Characteristics
Sex Distribution
Sex Factors
Venous Thrombosis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17139368

Citation

Couturaud, Francis, et al. "Incidence of Venous Thromboembolism in First-degree Relatives of Patients With Venous Thromboembolism Who Have Factor V Leiden." Thrombosis and Haemostasis, vol. 96, no. 6, 2006, pp. 744-9.
Couturaud F, Kearon C, Leroyer C, et al. Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost. 2006;96(6):744-9.
Couturaud, F., Kearon, C., Leroyer, C., Mercier, B., Abgrall, J. F., Le Gal, G., ... Mottier, D. (2006). Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thrombosis and Haemostasis, 96(6), pp. 744-9.
Couturaud F, et al. Incidence of Venous Thromboembolism in First-degree Relatives of Patients With Venous Thromboembolism Who Have Factor V Leiden. Thromb Haemost. 2006;96(6):744-9. PubMed PMID: 17139368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. AU - Couturaud,Francis, AU - Kearon,Clive, AU - Leroyer,Christophe, AU - Mercier,Bernard, AU - Abgrall,Jean Francois, AU - Le Gal,Grégoire, AU - Lacut,Karine, AU - Oger,Emmanuel, AU - Bressollette,Luc, AU - Ferec,Claude, AU - Lamure,Michel, AU - Mottier,Dominique, AU - ,, PY - 2006/12/2/pubmed PY - 2007/2/17/medline PY - 2006/12/2/entrez SP - 744 EP - 9 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 96 IS - 6 N2 - The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the incidence of objectively diagnosed first episodes of VTE was assessed in 553 first-degree relatives of 161 patients with acute VTE and FVL. The annual incidence of VTE was 0.43% (95% CI, 0.3 to 0.56) with FVL and 0.17% (95% CI, 0.07 to 0.27) without FVL (relative risk of 2.5,95% CI, 1.3 to 4.7). A majority (70%) of episodes of VTE were provoked, and this proportion was similar with and without FVL. A larger proportion of VTE was provoked in women (83%) that in men (33%), with the difference accounted for by pregnancy and use of oral contraceptives. The proportion of pregnancies complicated by VTE was 3.9% (95% CI, 2.0-5.8) with FVL and 1.4% (95% CI, 0.04-2.7) without FVL. FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/17139368/Incidence_of_venous_thromboembolism_in_first_degree_relatives_of_patients_with_venous_thromboembolism_who_have_factor_V_Leiden_ L2 - https://medlineplus.gov/pulmonaryembolism.html DB - PRIME DP - Unbound Medicine ER -