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Evaluation of anticarcinogenic effects of Clerodendron inerme on 7,12-dimethylbenz(a) anthracene-induced hamster buccal pouch carcinogenesis.
Singapore Med J. 2006 Dec; 47(12):1038-43.SM

Abstract

INTRODUCTION

Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50 percent) of oral malignancy. Clerodendron inerme is used by Indian traditional practitioners for the treatment of various ailments, including cancer. Our aim was to investigate the chemopreventive potential of the aqueous leaf extract of Clerodendron inerme (CiAet) in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis.

METHODS

We developed oral squamous cell carcinoma in the buccal pouch of male Syrian golden hamsters by painting them with 0.5% DMBA in liquid paraffin thrice a week for 14 weeks. The tumour incidence, tumour volume and tumour burden that were formed in the hamster buccal pouches were determined.

RESULTS

Oral administration of CiAet at a dose of 500 mg/kg body weight to DMBA-painted animals on days alternate to DMBA painting for 14 weeks significantly prevented the tumour incidence, tumour volume and tumour burden. CiAet also exerts potent antilipidperoxidative effect and improved the antioxidant defence system in DMBA-painted animals. The chemopreventive efficacy of CiAet was evident by inhibition of tumour formation (80%) in DMBA-painted animals.

CONCLUSION

The chemopreventive potential of CiAet is probably due to its antilipidperoxidative effect or the presence of some potent bioactive chemopreventive principles in the leaves of Clerodendron inerme.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India. manshisak@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17139399

Citation

Manoharan, S, et al. "Evaluation of Anticarcinogenic Effects of Clerodendron Inerme On 7,12-dimethylbenz(a) Anthracene-induced Hamster Buccal Pouch Carcinogenesis." Singapore Medical Journal, vol. 47, no. 12, 2006, pp. 1038-43.
Manoharan S, Kavitha K, Senthil N, et al. Evaluation of anticarcinogenic effects of Clerodendron inerme on 7,12-dimethylbenz(a) anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 2006;47(12):1038-43.
Manoharan, S., Kavitha, K., Senthil, N., & Renju, G. L. (2006). Evaluation of anticarcinogenic effects of Clerodendron inerme on 7,12-dimethylbenz(a) anthracene-induced hamster buccal pouch carcinogenesis. Singapore Medical Journal, 47(12), 1038-43.
Manoharan S, et al. Evaluation of Anticarcinogenic Effects of Clerodendron Inerme On 7,12-dimethylbenz(a) Anthracene-induced Hamster Buccal Pouch Carcinogenesis. Singapore Med J. 2006;47(12):1038-43. PubMed PMID: 17139399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of anticarcinogenic effects of Clerodendron inerme on 7,12-dimethylbenz(a) anthracene-induced hamster buccal pouch carcinogenesis. AU - Manoharan,S, AU - Kavitha,K, AU - Senthil,N, AU - Renju,G L, PY - 2006/12/2/pubmed PY - 2007/2/16/medline PY - 2006/12/2/entrez SP - 1038 EP - 43 JF - Singapore medical journal JO - Singapore Med J VL - 47 IS - 12 N2 - INTRODUCTION: Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50 percent) of oral malignancy. Clerodendron inerme is used by Indian traditional practitioners for the treatment of various ailments, including cancer. Our aim was to investigate the chemopreventive potential of the aqueous leaf extract of Clerodendron inerme (CiAet) in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. METHODS: We developed oral squamous cell carcinoma in the buccal pouch of male Syrian golden hamsters by painting them with 0.5% DMBA in liquid paraffin thrice a week for 14 weeks. The tumour incidence, tumour volume and tumour burden that were formed in the hamster buccal pouches were determined. RESULTS: Oral administration of CiAet at a dose of 500 mg/kg body weight to DMBA-painted animals on days alternate to DMBA painting for 14 weeks significantly prevented the tumour incidence, tumour volume and tumour burden. CiAet also exerts potent antilipidperoxidative effect and improved the antioxidant defence system in DMBA-painted animals. The chemopreventive efficacy of CiAet was evident by inhibition of tumour formation (80%) in DMBA-painted animals. CONCLUSION: The chemopreventive potential of CiAet is probably due to its antilipidperoxidative effect or the presence of some potent bioactive chemopreventive principles in the leaves of Clerodendron inerme. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/17139399/Evaluation_of_anticarcinogenic_effects_of_Clerodendron_inerme_on_712_dimethylbenz_a__anthracene_induced_hamster_buccal_pouch_carcinogenesis_ DB - PRIME DP - Unbound Medicine ER -