Tags

Type your tag names separated by a space and hit enter

PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid.
Neurotoxicology. 2007 May; 28(3):490-8.N

Abstract

PCBs are one of the environmental toxicants and neurotoxic compounds which induce the production of free radicals leading to oxidative stress. Oxidative stress is a contributing factor to alteration caused in neurodegenerative processes. The ability of Vitamin C to retard oxidative processes has been recognized for many years. Therefore, the present experiment was carried out to determine the antioxidant role of ascorbate on Aroclor 1254 induced oxidative stress in brain regions of albino rats. One group of rats received corn oil as vehicle for 30 days as control. The other group of rats were administered Aroclor 1254 at a dose of 2 mg/kg bw/day intraperitoneally for 30 days. One group of rats received Vitamin C (100 mg/kg bw/day) orally simultaneously with Aroclor 1254 for 30 days. The brain was dissected to cerebral cortex (Cc), cerebellum (C) and hippocampus (H). Enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), reduced glutathione (GSH) and Vitamin C were estimated. Hydrogen peroxide (H(2)O(2)), lipid peroxidation (LPO) and acetylcholine esterase activity (AchE) were determined. Activities of SOD, CAT, GPx, GST, AchE and the concentration of GSH, Vitamin C were decreased while an increase in H(2)O(2) and LPO were observed in brain regions of PCB treated animals. Vitamin C administration retrieved all the parameters except GST, significantly. These results suggest that PCB induces oxidative stress in rat brain by decreasing the activities of antioxidant enzymes, which can be protected by Vitamin C treatment.

Authors+Show Affiliations

Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17141323

Citation

Venkataraman, Prabhu, et al. "PCB (Aroclor 1254) Enhances Oxidative Damage in Rat Brain Regions: Protective Role of Ascorbic Acid." Neurotoxicology, vol. 28, no. 3, 2007, pp. 490-8.
Venkataraman P, Muthuvel R, Krishnamoorthy G, et al. PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. Neurotoxicology. 2007;28(3):490-8.
Venkataraman, P., Muthuvel, R., Krishnamoorthy, G., Arunkumar, A., Sridhar, M., Srinivasan, N., Balasubramanian, K., Aruldhas, M. M., & Arunakaran, J. (2007). PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. Neurotoxicology, 28(3), 490-8.
Venkataraman P, et al. PCB (Aroclor 1254) Enhances Oxidative Damage in Rat Brain Regions: Protective Role of Ascorbic Acid. Neurotoxicology. 2007;28(3):490-8. PubMed PMID: 17141323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. AU - Venkataraman,Prabhu, AU - Muthuvel,Raju, AU - Krishnamoorthy,Gunasekaran, AU - Arunkumar,Arumugam, AU - Sridhar,Muthusami, AU - Srinivasan,Narasimhan, AU - Balasubramanian,Karundevi, AU - Aruldhas,Maria Michael, AU - Arunakaran,Jagadeesan, Y1 - 2006/12/01/ PY - 2005/12/22/received PY - 2006/09/26/revised PY - 2006/11/01/accepted PY - 2006/12/5/pubmed PY - 2007/10/19/medline PY - 2006/12/5/entrez SP - 490 EP - 8 JF - Neurotoxicology JO - Neurotoxicology VL - 28 IS - 3 N2 - PCBs are one of the environmental toxicants and neurotoxic compounds which induce the production of free radicals leading to oxidative stress. Oxidative stress is a contributing factor to alteration caused in neurodegenerative processes. The ability of Vitamin C to retard oxidative processes has been recognized for many years. Therefore, the present experiment was carried out to determine the antioxidant role of ascorbate on Aroclor 1254 induced oxidative stress in brain regions of albino rats. One group of rats received corn oil as vehicle for 30 days as control. The other group of rats were administered Aroclor 1254 at a dose of 2 mg/kg bw/day intraperitoneally for 30 days. One group of rats received Vitamin C (100 mg/kg bw/day) orally simultaneously with Aroclor 1254 for 30 days. The brain was dissected to cerebral cortex (Cc), cerebellum (C) and hippocampus (H). Enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), reduced glutathione (GSH) and Vitamin C were estimated. Hydrogen peroxide (H(2)O(2)), lipid peroxidation (LPO) and acetylcholine esterase activity (AchE) were determined. Activities of SOD, CAT, GPx, GST, AchE and the concentration of GSH, Vitamin C were decreased while an increase in H(2)O(2) and LPO were observed in brain regions of PCB treated animals. Vitamin C administration retrieved all the parameters except GST, significantly. These results suggest that PCB induces oxidative stress in rat brain by decreasing the activities of antioxidant enzymes, which can be protected by Vitamin C treatment. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/17141323/PCB__Aroclor_1254__enhances_oxidative_damage_in_rat_brain_regions:_protective_role_of_ascorbic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(06)00292-0 DB - PRIME DP - Unbound Medicine ER -