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Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota.
Int J Antimicrob Agents 2007; 29(1):66-72IJ

Abstract

The aims of this study were (i) to evaluate the effect of recommended antimicrobial treatment of Helicobacter pylori infection, consisting of clarithromycin, amoxicillin and lansoprazole, on intestinal microbiota and (ii) to determine the ability of a probiotic combination containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Propionibacterium freudenreichii ssp. shermanii JS and Bifidobacterium breve Bb99 to prevent treatment-induced alterations in the intestinal microbiota. Faecal samples were obtained from 39 H. pylori-infected patients randomised into two treatment groups. In addition, 19 H. pylori-negative volunteers were included in the study as a control group. Samples were collected before, during and after treatment and microbiota were analysed by fluorescence in situ hybridisation and culture. The quantities of the predominant bacterial groups were altered significantly in both groups and disturbances were seen even 9 weeks after treatment was complete. Probiotics slightly counteracted the effects of anti-H. pylori treatment, seen as significantly less alterations in the total numbers of aerobes and lactobacilli/enterococci. At baseline, the composition of the microbiota between H. pylori-positive versus H. pylori-negative control individuals differed with regard to clostridia and the total number of anaerobes. The recommended treatment for H. pylori infection induces long-term disturbances in the intestinal microbiota. The probiotic combination appeared to result in only minor changes in the microbiota.

Authors+Show Affiliations

Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland; Foundation for Nutrition Research, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17141481

Citation

Myllyluoma, E, et al. "Effects of anti-Helicobacter Pylori Treatment and Probiotic Supplementation On Intestinal Microbiota." International Journal of Antimicrobial Agents, vol. 29, no. 1, 2007, pp. 66-72.
Myllyluoma E, Ahlroos T, Veijola L, et al. Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota. Int J Antimicrob Agents. 2007;29(1):66-72.
Myllyluoma, E., Ahlroos, T., Veijola, L., Rautelin, H., Tynkkynen, S., & Korpela, R. (2007). Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota. International Journal of Antimicrobial Agents, 29(1), pp. 66-72.
Myllyluoma E, et al. Effects of anti-Helicobacter Pylori Treatment and Probiotic Supplementation On Intestinal Microbiota. Int J Antimicrob Agents. 2007;29(1):66-72. PubMed PMID: 17141481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of anti-Helicobacter pylori treatment and probiotic supplementation on intestinal microbiota. AU - Myllyluoma,E, AU - Ahlroos,T, AU - Veijola,L, AU - Rautelin,H, AU - Tynkkynen,S, AU - Korpela,R, Y1 - 2006/12/01/ PY - 2006/06/26/received PY - 2006/08/21/revised PY - 2006/08/21/accepted PY - 2006/12/5/pubmed PY - 2007/3/21/medline PY - 2006/12/5/entrez SP - 66 EP - 72 JF - International journal of antimicrobial agents JO - Int. J. Antimicrob. Agents VL - 29 IS - 1 N2 - The aims of this study were (i) to evaluate the effect of recommended antimicrobial treatment of Helicobacter pylori infection, consisting of clarithromycin, amoxicillin and lansoprazole, on intestinal microbiota and (ii) to determine the ability of a probiotic combination containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Propionibacterium freudenreichii ssp. shermanii JS and Bifidobacterium breve Bb99 to prevent treatment-induced alterations in the intestinal microbiota. Faecal samples were obtained from 39 H. pylori-infected patients randomised into two treatment groups. In addition, 19 H. pylori-negative volunteers were included in the study as a control group. Samples were collected before, during and after treatment and microbiota were analysed by fluorescence in situ hybridisation and culture. The quantities of the predominant bacterial groups were altered significantly in both groups and disturbances were seen even 9 weeks after treatment was complete. Probiotics slightly counteracted the effects of anti-H. pylori treatment, seen as significantly less alterations in the total numbers of aerobes and lactobacilli/enterococci. At baseline, the composition of the microbiota between H. pylori-positive versus H. pylori-negative control individuals differed with regard to clostridia and the total number of anaerobes. The recommended treatment for H. pylori infection induces long-term disturbances in the intestinal microbiota. The probiotic combination appeared to result in only minor changes in the microbiota. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/17141481/Effects_of_anti_Helicobacter_pylori_treatment_and_probiotic_supplementation_on_intestinal_microbiota_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(06)00391-8 DB - PRIME DP - Unbound Medicine ER -