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Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children.
Phytomedicine 2007; 14(2-3):96-101P

Abstract

Mao-to is a Japanese traditional herbal medicine which has been used since ancient times for the treatment of influenza-like illness. This study was conducted to evaluate the effect of oral Mao-to administration in children with type A influenza, in comparison to Oseltamivir. We performed a controlled trial of 60 children, from 5 months through 13 years of age, with fever and influenza-like symptom of up to 48 h duration. Diagnosis of influenza type A was performed by virus isolation or detection of a viral gene by RT-PCR. Patients assigned into the following 3 groups: oral Mao-to powder (TJ-27) 0.06 g/kg body wt./dose three times daily (n=17), Oseltamivir 2 mg/kg body wt./dose twice daily (n=18) or both oral Mao-to plus Oseltamivir (n=14). The median duration of fever after treatment was significantly shorter in the Mao-to and Mao-to plus Oseltamivir groups, compared with the Oseltamivir only group (15 h [95%CI 13.2-22.1] p<0.01; 18 h[15.2-27.7] p<0.05; 24 h[23.5-43.0], respectively). Oral Mao-to administration was effective in the control of fever due to type A influenza infection in children.

Authors+Show Affiliations

Department of Pediatrics, Self Defense Force Sendai Hospital, Minaminometate 1-1, Miyaginoku, Sendai, Miyagi, Japan. bokukubo17@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17141491

Citation

Kubo, Tomohiro, and Hidekazu Nishimura. "Antipyretic Effect of Mao-to, a Japanese Herbal Medicine, for Treatment of Type a Influenza Infection in Children." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 14, no. 2-3, 2007, pp. 96-101.
Kubo T, Nishimura H. Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children. Phytomedicine. 2007;14(2-3):96-101.
Kubo, T., & Nishimura, H. (2007). Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 14(2-3), pp. 96-101.
Kubo T, Nishimura H. Antipyretic Effect of Mao-to, a Japanese Herbal Medicine, for Treatment of Type a Influenza Infection in Children. Phytomedicine. 2007;14(2-3):96-101. PubMed PMID: 17141491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children. AU - Kubo,Tomohiro, AU - Nishimura,Hidekazu, Y1 - 2006/12/01/ PY - 2006/12/5/pubmed PY - 2007/4/11/medline PY - 2006/12/5/entrez SP - 96 EP - 101 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 14 IS - 2-3 N2 - Mao-to is a Japanese traditional herbal medicine which has been used since ancient times for the treatment of influenza-like illness. This study was conducted to evaluate the effect of oral Mao-to administration in children with type A influenza, in comparison to Oseltamivir. We performed a controlled trial of 60 children, from 5 months through 13 years of age, with fever and influenza-like symptom of up to 48 h duration. Diagnosis of influenza type A was performed by virus isolation or detection of a viral gene by RT-PCR. Patients assigned into the following 3 groups: oral Mao-to powder (TJ-27) 0.06 g/kg body wt./dose three times daily (n=17), Oseltamivir 2 mg/kg body wt./dose twice daily (n=18) or both oral Mao-to plus Oseltamivir (n=14). The median duration of fever after treatment was significantly shorter in the Mao-to and Mao-to plus Oseltamivir groups, compared with the Oseltamivir only group (15 h [95%CI 13.2-22.1] p<0.01; 18 h[15.2-27.7] p<0.05; 24 h[23.5-43.0], respectively). Oral Mao-to administration was effective in the control of fever due to type A influenza infection in children. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/17141491/Antipyretic_effect_of_Mao_to_a_Japanese_herbal_medicine_for_treatment_of_type_A_influenza_infection_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(06)00142-5 DB - PRIME DP - Unbound Medicine ER -