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Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats.
J Ethnopharmacol. 2007 Apr 04; 110(3):434-8.JE

Abstract

Sclerocarya birrea (Anacardiaceae) is used as a traditional treatment of diabetes in Cameroon. In this study, we investigated the possible antidiabetic effect of the stem bark extract in diabetic rats. Diabetes was induced by intravenous injection of streptozotocin (STZ, 55 mg/kg) to male Wistar rats. Experimental animals (six per group), were treated by oral administration of plant extract (150 and 300 mg/kg body weight) and metformin (500 mg/kg; reference drug) for comparison, during 21 days. The stem bark methanol/methylene chloride extract of Sclerocarya birrea exhibited at termination, a significant reduction in blood glucose and increased plasma insulin levels in diabetic rats. The extract also prevented body weight loss in diabetic rats. The effective dose of the plant extract (300 mg/kg) tended to reduce plasma cholesterol, triglyceride and urea levels toward the normal levels. Four days after diabetes induction, an oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The results showed a significant improvement in glucose tolerance in rats treated with Sclerocarya birrea extract. Metformin, a known antidiabetic drug (500 mg/kg), significantly decreased the integrated area under the glucose curve. These data indicate that Sclerocarya birrea treatment may improve glucose homeostasis in STZ-induced diabetes which could be associated with stimulation of insulin secretion.

Authors+Show Affiliations

Department of Animal Biology and Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. dimo59@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17141993

Citation

Dimo, Théophile, et al. "Effect of Sclerocarya Birrea (Anacardiaceae) Stem Bark Methylene Chloride/methanol Extract On Streptozotocin-diabetic Rats." Journal of Ethnopharmacology, vol. 110, no. 3, 2007, pp. 434-8.
Dimo T, Rakotonirina SV, Tan PV, et al. Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats. J Ethnopharmacol. 2007;110(3):434-8.
Dimo, T., Rakotonirina, S. V., Tan, P. V., Azay, J., Dongo, E., Kamtchouing, P., & Cros, G. (2007). Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats. Journal of Ethnopharmacology, 110(3), 434-8.
Dimo T, et al. Effect of Sclerocarya Birrea (Anacardiaceae) Stem Bark Methylene Chloride/methanol Extract On Streptozotocin-diabetic Rats. J Ethnopharmacol. 2007 Apr 4;110(3):434-8. PubMed PMID: 17141993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats. AU - Dimo,Théophile, AU - Rakotonirina,Silvere V, AU - Tan,Paul V, AU - Azay,Jacqueline, AU - Dongo,Etienne, AU - Kamtchouing,Pierre, AU - Cros,Gérard, Y1 - 2006/10/26/ PY - 2005/1/7/received PY - 2006/8/29/revised PY - 2006/10/12/accepted PY - 2006/12/5/pubmed PY - 2007/6/15/medline PY - 2006/12/5/entrez SP - 434 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 110 IS - 3 N2 - Sclerocarya birrea (Anacardiaceae) is used as a traditional treatment of diabetes in Cameroon. In this study, we investigated the possible antidiabetic effect of the stem bark extract in diabetic rats. Diabetes was induced by intravenous injection of streptozotocin (STZ, 55 mg/kg) to male Wistar rats. Experimental animals (six per group), were treated by oral administration of plant extract (150 and 300 mg/kg body weight) and metformin (500 mg/kg; reference drug) for comparison, during 21 days. The stem bark methanol/methylene chloride extract of Sclerocarya birrea exhibited at termination, a significant reduction in blood glucose and increased plasma insulin levels in diabetic rats. The extract also prevented body weight loss in diabetic rats. The effective dose of the plant extract (300 mg/kg) tended to reduce plasma cholesterol, triglyceride and urea levels toward the normal levels. Four days after diabetes induction, an oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The results showed a significant improvement in glucose tolerance in rats treated with Sclerocarya birrea extract. Metformin, a known antidiabetic drug (500 mg/kg), significantly decreased the integrated area under the glucose curve. These data indicate that Sclerocarya birrea treatment may improve glucose homeostasis in STZ-induced diabetes which could be associated with stimulation of insulin secretion. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17141993/Effect_of_Sclerocarya_birrea__Anacardiaceae__stem_bark_methylene_chloride/methanol_extract_on_streptozotocin_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -