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Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm.
Learn Mem. 2006 Nov-Dec; 13(6):681-5.LM

Abstract

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS- discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures.

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Authors+Show Affiliations

Norrholm SD
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA. Seth.Norrholm@va.gov
Jovanovic T
No affiliation info available
Vervliet B
No affiliation info available
Myers KM
No affiliation info available
Davis M
No affiliation info available
Rothbaum BO
No affiliation info available
Duncan EJ
No affiliation info available

MeSH

Conditioning, ClassicalDiscrimination LearningExtinction, PsychologicalFearHumansPsychopharmacologyPsychophysicsReflex, StartleSet, Psychology

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Validation Study

Language

eng

PubMed ID

17142300

Citation

Norrholm, Seth D., et al. "Conditioned Fear Extinction and Reinstatement in a Human Fear-potentiated Startle Paradigm." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 13, no. 6, 2006, pp. 681-5.
Norrholm SD, Jovanovic T, Vervliet B, et al. Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm. Learn Mem. 2006;13(6):681-5.
Norrholm, S. D., Jovanovic, T., Vervliet, B., Myers, K. M., Davis, M., Rothbaum, B. O., & Duncan, E. J. (2006). Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm. Learning & Memory (Cold Spring Harbor, N.Y.), 13(6), 681-5.
Norrholm SD, et al. Conditioned Fear Extinction and Reinstatement in a Human Fear-potentiated Startle Paradigm. Learn Mem. 2006 Nov-Dec;13(6):681-5. PubMed PMID: 17142300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm. AU - Norrholm,Seth D, AU - Jovanovic,Tanja, AU - Vervliet,Bram, AU - Myers,Karyn M, AU - Davis,Michael, AU - Rothbaum,Barbara O, AU - Duncan,Erica J, PY - 2006/12/5/pubmed PY - 2007/1/26/medline PY - 2006/12/5/entrez SP - 681 EP - 5 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 13 IS - 6 N2 - The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS- discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/17142300/Conditioned_fear_extinction_and_reinstatement_in_a_human_fear_potentiated_startle_paradigm_ DB - PRIME DP - Unbound Medicine ER -