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Dietary vitamin K intake and anticoagulation in elderly patients.
Curr Opin Clin Nutr Metab Care. 2007 Jan; 10(1):1-5.CO

Abstract

PURPOSE OF REVIEW

Vitamin K is an essential co-factor for the synthesis of several coagulation factors. Oral anticoagulants competitively inhibit enzymes that participate in vitamin K metabolism. The purpose of this review is to evaluate the potential interaction of dietary vitamin K and coagulation stability, particularly in the elderly patient.

RECENT FINDINGS

Recent prospective evidences suggest that dietary vitamin K plays an essential role in anticoagulation stability. Vitamin K intake of more than 250 microg/day was shown to decrease warfarin sensitivity in anticoagulated patients consuming regular diets. In a randomized crossover study, brief periods of changes on vitamin K intake also had significant effects on coagulation parameters. Patients that were allocated to an 80% decrease of intake increased International Normalized Ratio (INR) by almost 30% 7 days after the intervention. Similarly, it was estimated by dietary records that for each increase in 100 microg of vitamin K intake, the INR would be reduced by 0.2. A recent study also demonstrated that over-the-counter multivitamin supplements contain enough vitamin K1 to significantly alter coagulation parameters.

SUMMARY

Contemporary data strengthen the concept that the interaction between dietary vitamin K and coumarin derivatives is clinically relevant and plays a major role in INR fluctuations in chronic anticoagulated patients.

Authors+Show Affiliations

Cardiovascular Division of Hospital de Clínicas de Porto Alegre, Post-Graduation Program in Cardiovascular Sciences and Cardiology, Federal University of Rio Grande do Sul, Brazil. lerohde@terra.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17143047

Citation

Rohde, Luis Eduardo, et al. "Dietary Vitamin K Intake and Anticoagulation in Elderly Patients." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 10, no. 1, 2007, pp. 1-5.
Rohde LE, de Assis MC, Rabelo ER. Dietary vitamin K intake and anticoagulation in elderly patients. Curr Opin Clin Nutr Metab Care. 2007;10(1):1-5.
Rohde, L. E., de Assis, M. C., & Rabelo, E. R. (2007). Dietary vitamin K intake and anticoagulation in elderly patients. Current Opinion in Clinical Nutrition and Metabolic Care, 10(1), 1-5.
Rohde LE, de Assis MC, Rabelo ER. Dietary Vitamin K Intake and Anticoagulation in Elderly Patients. Curr Opin Clin Nutr Metab Care. 2007;10(1):1-5. PubMed PMID: 17143047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary vitamin K intake and anticoagulation in elderly patients. AU - Rohde,Luis Eduardo, AU - de Assis,Michelli Cristina Silva, AU - Rabelo,Eneida Rejane, PY - 2006/12/5/pubmed PY - 2007/3/3/medline PY - 2006/12/5/entrez SP - 1 EP - 5 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 10 IS - 1 N2 - PURPOSE OF REVIEW: Vitamin K is an essential co-factor for the synthesis of several coagulation factors. Oral anticoagulants competitively inhibit enzymes that participate in vitamin K metabolism. The purpose of this review is to evaluate the potential interaction of dietary vitamin K and coagulation stability, particularly in the elderly patient. RECENT FINDINGS: Recent prospective evidences suggest that dietary vitamin K plays an essential role in anticoagulation stability. Vitamin K intake of more than 250 microg/day was shown to decrease warfarin sensitivity in anticoagulated patients consuming regular diets. In a randomized crossover study, brief periods of changes on vitamin K intake also had significant effects on coagulation parameters. Patients that were allocated to an 80% decrease of intake increased International Normalized Ratio (INR) by almost 30% 7 days after the intervention. Similarly, it was estimated by dietary records that for each increase in 100 microg of vitamin K intake, the INR would be reduced by 0.2. A recent study also demonstrated that over-the-counter multivitamin supplements contain enough vitamin K1 to significantly alter coagulation parameters. SUMMARY: Contemporary data strengthen the concept that the interaction between dietary vitamin K and coumarin derivatives is clinically relevant and plays a major role in INR fluctuations in chronic anticoagulated patients. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/17143047/Dietary_vitamin_K_intake_and_anticoagulation_in_elderly_patients_ L2 - https://doi.org/10.1097/MCO.0b013e328011c46c DB - PRIME DP - Unbound Medicine ER -