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Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention.
Clin Infect Dis. 2007 Jan 01; 44(1):13-22.CI

Abstract

BACKGROUND

Trichomonas vaginalis causes a common sexually transmitted infection (STI) in women, yet trichomoniasis in male sexual partners is not well recognized. Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture.

METHODS

We conducted a prospective, multicenter study to evaluate T. vaginalis infection among male partners of women with trichomoniasis and factors associated with infection by recruiting patients from 3 public clinics in the United States. Male partners were tested for concordant T. vaginalis infection, defined as a positive urethral culture, urine culture, or urine polymerase chain reaction (PCR) result. A subset of men also provided a semen sample for T. vaginalis culture and PCR. Factors associated with concordant infection were determined from bivariable and multivariable analyses.

RESULTS

We enrolled 540 women with trichomoniasis (diagnosed using wet mount microscopy and/or culture) and 261 (48.4%) of their male partners. T. vaginalis infection was detected in 177 (71.7%) of 256 male partners (95% confidence interval [CI], 66.0%-77.3%), of whom 136 (77.3%) were asymptomatic. A vaginal pH of >4.5 in a woman was independently associated with infection in the male partner (adjusted odds ratio, 2.5; 95% CI, 1.0-6.3). Younger male age (20-29 and 30-39 years) was also found to be an independent risk factor for concordant trichomoniasis.

CONCLUSIONS

The majority of male partners of women with trichomoniasis were infected; however, few factors predicted infection. T. vaginalis causes a highly prevalent STI, necessitating vastly improved partner management, application of sensitive nucleic-acid based testing, and better clinical recognition.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. idrod@med.unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17143809

Citation

Seña, Arlene C., et al. "Trichomonas Vaginalis Infection in Male Sexual Partners: Implications for Diagnosis, Treatment, and Prevention." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 44, no. 1, 2007, pp. 13-22.
Seña AC, Miller WC, Hobbs MM, et al. Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention. Clin Infect Dis. 2007;44(1):13-22.
Seña, A. C., Miller, W. C., Hobbs, M. M., Schwebke, J. R., Leone, P. A., Swygard, H., Atashili, J., & Cohen, M. S. (2007). Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 44(1), 13-22.
Seña AC, et al. Trichomonas Vaginalis Infection in Male Sexual Partners: Implications for Diagnosis, Treatment, and Prevention. Clin Infect Dis. 2007 Jan 1;44(1):13-22. PubMed PMID: 17143809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention. AU - Seña,Arlene C, AU - Miller,William C, AU - Hobbs,Marcia M, AU - Schwebke,Jane R, AU - Leone,Peter A, AU - Swygard,Heidi, AU - Atashili,Julius, AU - Cohen,Myron S, Y1 - 2006/11/27/ PY - 2006/05/03/received PY - 2006/08/29/accepted PY - 2006/12/5/pubmed PY - 2007/1/16/medline PY - 2006/12/5/entrez SP - 13 EP - 22 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 44 IS - 1 N2 - BACKGROUND: Trichomonas vaginalis causes a common sexually transmitted infection (STI) in women, yet trichomoniasis in male sexual partners is not well recognized. Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture. METHODS: We conducted a prospective, multicenter study to evaluate T. vaginalis infection among male partners of women with trichomoniasis and factors associated with infection by recruiting patients from 3 public clinics in the United States. Male partners were tested for concordant T. vaginalis infection, defined as a positive urethral culture, urine culture, or urine polymerase chain reaction (PCR) result. A subset of men also provided a semen sample for T. vaginalis culture and PCR. Factors associated with concordant infection were determined from bivariable and multivariable analyses. RESULTS: We enrolled 540 women with trichomoniasis (diagnosed using wet mount microscopy and/or culture) and 261 (48.4%) of their male partners. T. vaginalis infection was detected in 177 (71.7%) of 256 male partners (95% confidence interval [CI], 66.0%-77.3%), of whom 136 (77.3%) were asymptomatic. A vaginal pH of >4.5 in a woman was independently associated with infection in the male partner (adjusted odds ratio, 2.5; 95% CI, 1.0-6.3). Younger male age (20-29 and 30-39 years) was also found to be an independent risk factor for concordant trichomoniasis. CONCLUSIONS: The majority of male partners of women with trichomoniasis were infected; however, few factors predicted infection. T. vaginalis causes a highly prevalent STI, necessitating vastly improved partner management, application of sensitive nucleic-acid based testing, and better clinical recognition. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/17143809/Trichomonas_vaginalis_infection_in_male_sexual_partners:_implications_for_diagnosis_treatment_and_prevention_ DB - PRIME DP - Unbound Medicine ER -