Tags

Type your tag names separated by a space and hit enter

Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats.
Toxicology. 2007 Jan 05; 229(1-2):165-72.T

Abstract

The present study was aimed to find out the protective effect of bezafibrate on lipid peroxidation (LPO), activities of both enzymatic and non-enzymatic antioxidants and histopathological examination of pancreas in streptozotocin (STZ)-induced diabetic rats. Experimental diabetes was induced by a single dose of STZ (60mg/kg, i.p.) injection. The oxidative stress was measured by tissue LPO level, reduced glutathione (GSH) content and by enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in liver and pancreas. Biochemical observations were further substantiated with histological examination of pancreas. The increase in blood glucose, LPO level with reduction in GSH content and decreased enzymatic activities were the salient features observed in diabetic control rats. Administration of bezafibrate (30mg/kg day, p.o.) for 15 days caused a significant reduction in blood glucose and LPO level in STZ treated rats (group III) when compared with diabetic control rats (group II). Furthermore, bezafibrate treated diabetic rats (group III) showed significant increase in the activities of both enzymatic and non-enzymatic antioxidants when compared to diabetic control rats (group II). Degenerative changes of pancreatic beta-cells in STZ treated rats were minimized to near normal morphology by administration of bezafibrate as evident by histopathological examination. The results obtained clearly indicate the role of oxidative stress in the induction of diabetes and suggest a protective effect of bezafibrate in this animal model.

Authors+Show Affiliations

Anwer T
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India.
Sharma M
No affiliation info available
Pillai KK
No affiliation info available
Haque SE
No affiliation info available
Alam MM
No affiliation info available
Zaman MS
No affiliation info available

MeSH

Administration, OralAnimalsAntioxidantsBezafibrateBlood GlucoseCatalaseDiabetes Mellitus, ExperimentalGlutathioneGlutathione PeroxidaseHyperglycemiaHypolipidemic AgentsInjections, IntraperitonealInsulin-Secreting CellsIslets of LangerhansLipid PeroxidationLiverMaleMalondialdehydeOxidative StressRatsRats, WistarStreptozocinSuperoxide DismutaseTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17145126

Citation

Anwer, Tarique, et al. "Protective Effect of Bezafibrate On Streptozotocin-induced Oxidative Stress and Toxicity in Rats." Toxicology, vol. 229, no. 1-2, 2007, pp. 165-72.
Anwer T, Sharma M, Pillai KK, et al. Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats. Toxicology. 2007;229(1-2):165-72.
Anwer, T., Sharma, M., Pillai, K. K., Haque, S. E., Alam, M. M., & Zaman, M. S. (2007). Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats. Toxicology, 229(1-2), 165-72.
Anwer T, et al. Protective Effect of Bezafibrate On Streptozotocin-induced Oxidative Stress and Toxicity in Rats. Toxicology. 2007 Jan 5;229(1-2):165-72. PubMed PMID: 17145126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats. AU - Anwer,Tarique, AU - Sharma,Manju, AU - Pillai,K K, AU - Haque,S E, AU - Alam,M M, AU - Zaman,M S, Y1 - 2006/12/04/ PY - 2006/09/12/received PY - 2006/10/13/revised PY - 2006/10/21/accepted PY - 2006/12/6/pubmed PY - 2007/4/20/medline PY - 2006/12/6/entrez SP - 165 EP - 72 JF - Toxicology JO - Toxicology VL - 229 IS - 1-2 N2 - The present study was aimed to find out the protective effect of bezafibrate on lipid peroxidation (LPO), activities of both enzymatic and non-enzymatic antioxidants and histopathological examination of pancreas in streptozotocin (STZ)-induced diabetic rats. Experimental diabetes was induced by a single dose of STZ (60mg/kg, i.p.) injection. The oxidative stress was measured by tissue LPO level, reduced glutathione (GSH) content and by enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in liver and pancreas. Biochemical observations were further substantiated with histological examination of pancreas. The increase in blood glucose, LPO level with reduction in GSH content and decreased enzymatic activities were the salient features observed in diabetic control rats. Administration of bezafibrate (30mg/kg day, p.o.) for 15 days caused a significant reduction in blood glucose and LPO level in STZ treated rats (group III) when compared with diabetic control rats (group II). Furthermore, bezafibrate treated diabetic rats (group III) showed significant increase in the activities of both enzymatic and non-enzymatic antioxidants when compared to diabetic control rats (group II). Degenerative changes of pancreatic beta-cells in STZ treated rats were minimized to near normal morphology by administration of bezafibrate as evident by histopathological examination. The results obtained clearly indicate the role of oxidative stress in the induction of diabetes and suggest a protective effect of bezafibrate in this animal model. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17145126/Protective_effect_of_bezafibrate_on_streptozotocin_induced_oxidative_stress_and_toxicity_in_rats_ DB - PRIME DP - Unbound Medicine ER -