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Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study.

Abstract

To assess the hypothesis that magnesium intake is beneficial in the primary prevention of hypertension, 28,349 female United States health professionals aged > or =45 years participating in the Women's Health Study (WHS), who initially reported normal blood pressure (systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg, no history of hypertension or antihypertensive medications), were prospectively studied. A semi-quantitative food frequency questionnaire was used to estimate magnesium intake. During a median follow-up of 9.8 years, 8,544 women developed incident hypertension. After adjustment for age and randomized treatment, magnesium intake was inversely associated with the risk for developing hypertension; women in the highest quintile (median 434 mg/day) had a decreased risk for hypertension (relative risk 0.87, 95% confidence interval [CI] 0.81 to 0.93, p for trend <0.0001) compared with those in the lowest quintile (median 256 mg/day). This inverse association was attenuated but remained significant after further adjustment for known risk factors. In the fully adjusted model, the relative risks were 1.00 (95% CI 0.95 to 1.10), 1.02 (95% CI 0.95 to 1.10), 0.96 (95% CI 0.89 to 1.03), and 0.93 (95% CI 0.86 to 1.02) (p for trend = 0.03). Similar associations were observed for women who never smoked and reported no history of high cholesterol or diabetes at baseline. In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ysong3@rics.bwh.harvard.edu

    , , , ,

    Source

    The American journal of cardiology 98:12 2006 Dec 15 pg 1616-21

    MeSH

    Cohort Studies
    Diet
    Female
    Follow-Up Studies
    Humans
    Hypertension
    Magnesium
    Middle Aged
    Randomized Controlled Trials as Topic
    Risk

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17145221

    Citation

    Song, Yiqing, et al. "Dietary Magnesium Intake and Risk of Incident Hypertension Among Middle-aged and Older US Women in a 10-year Follow-up Study." The American Journal of Cardiology, vol. 98, no. 12, 2006, pp. 1616-21.
    Song Y, Sesso HD, Manson JE, et al. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol. 2006;98(12):1616-21.
    Song, Y., Sesso, H. D., Manson, J. E., Cook, N. R., Buring, J. E., & Liu, S. (2006). Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. The American Journal of Cardiology, 98(12), pp. 1616-21.
    Song Y, et al. Dietary Magnesium Intake and Risk of Incident Hypertension Among Middle-aged and Older US Women in a 10-year Follow-up Study. Am J Cardiol. 2006 Dec 15;98(12):1616-21. PubMed PMID: 17145221.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. AU - Song,Yiqing, AU - Sesso,Howard D, AU - Manson,JoAnn E, AU - Cook,Nancy R, AU - Buring,Julie E, AU - Liu,Simin, Y1 - 2006/10/23/ PY - 2006/03/31/received PY - 2006/07/03/revised PY - 2006/07/03/accepted PY - 2006/12/6/pubmed PY - 2007/1/31/medline PY - 2006/12/6/entrez SP - 1616 EP - 21 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 98 IS - 12 N2 - To assess the hypothesis that magnesium intake is beneficial in the primary prevention of hypertension, 28,349 female United States health professionals aged > or =45 years participating in the Women's Health Study (WHS), who initially reported normal blood pressure (systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg, no history of hypertension or antihypertensive medications), were prospectively studied. A semi-quantitative food frequency questionnaire was used to estimate magnesium intake. During a median follow-up of 9.8 years, 8,544 women developed incident hypertension. After adjustment for age and randomized treatment, magnesium intake was inversely associated with the risk for developing hypertension; women in the highest quintile (median 434 mg/day) had a decreased risk for hypertension (relative risk 0.87, 95% confidence interval [CI] 0.81 to 0.93, p for trend <0.0001) compared with those in the lowest quintile (median 256 mg/day). This inverse association was attenuated but remained significant after further adjustment for known risk factors. In the fully adjusted model, the relative risks were 1.00 (95% CI 0.95 to 1.10), 1.02 (95% CI 0.95 to 1.10), 0.96 (95% CI 0.89 to 1.03), and 0.93 (95% CI 0.86 to 1.02) (p for trend = 0.03). Similar associations were observed for women who never smoked and reported no history of high cholesterol or diabetes at baseline. In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17145221/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)01716-4 DB - PRIME DP - Unbound Medicine ER -