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Clinical, serologic, and genetic profiles of patients with associated Sjögren's syndrome and systemic lupus erythematosus.
Hum Immunol. 2006 Nov; 67(11):924-30.HI

Abstract

Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) can coexist in patients. The aim of this study was to investigate the clinical, laboratory, and serologic features of the association of the two diseases. Data from 56 patients having both SS and SLE were analyzed, with special emphasis on their clinical, laboratory, and serologic features. Data from 50 patients with SLE and 50 patients with SS served as control subjects. The mean age in SS-SLE group was lower than in patients with SS but higher than patients with SLE. When SLE and SS were associated, presence of rheumatoid factor was less frequent, whereas anti-Ro/SS-A, anti-La/SS-B, antinuclear, anti-DNA, and antiphospholipid autoantibodies appeared more often. Antiphospholipid syndrome, anemia, leucopenia, and lymphopenia were more frequent in the associated disease than in patients with SS alone. In SS-SLE patients, pulmonary, renal, skin, central nervous system involvement, and serositis occurred more often than in patients with SS alone. Thyroiditis, autoantibodies to Ro/SS-A, La/SS-B and ds-DNA was more frequent in the SS-SLE group than in patients with SLE. Genetic background of the patients did not differ significantly. In conclusion, characteristic clinical, laboratory and serologic features distinguish between the association of SS and SLE and the primary forms of these two diseases.

Authors+Show Affiliations

3rd Department of Internal Medicine, Division of Clinical Immunology, Institute for Internal Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17145372

Citation

Szanto, Antonia, et al. "Clinical, Serologic, and Genetic Profiles of Patients With Associated Sjögren's Syndrome and Systemic Lupus Erythematosus." Human Immunology, vol. 67, no. 11, 2006, pp. 924-30.
Szanto A, Szodoray P, Kiss E, et al. Clinical, serologic, and genetic profiles of patients with associated Sjögren's syndrome and systemic lupus erythematosus. Hum Immunol. 2006;67(11):924-30.
Szanto, A., Szodoray, P., Kiss, E., Kapitany, A., Szegedi, G., & Zeher, M. (2006). Clinical, serologic, and genetic profiles of patients with associated Sjögren's syndrome and systemic lupus erythematosus. Human Immunology, 67(11), 924-30.
Szanto A, et al. Clinical, Serologic, and Genetic Profiles of Patients With Associated Sjögren's Syndrome and Systemic Lupus Erythematosus. Hum Immunol. 2006;67(11):924-30. PubMed PMID: 17145372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical, serologic, and genetic profiles of patients with associated Sjögren's syndrome and systemic lupus erythematosus. AU - Szanto,Antonia, AU - Szodoray,Peter, AU - Kiss,Emese, AU - Kapitany,Aniko, AU - Szegedi,Gyula, AU - Zeher,Margit, Y1 - 2006/08/10/ PY - 2006/05/04/received PY - 2006/06/20/revised PY - 2006/06/29/accepted PY - 2006/12/6/pubmed PY - 2007/1/20/medline PY - 2006/12/6/entrez SP - 924 EP - 30 JF - Human immunology JO - Hum. Immunol. VL - 67 IS - 11 N2 - Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) can coexist in patients. The aim of this study was to investigate the clinical, laboratory, and serologic features of the association of the two diseases. Data from 56 patients having both SS and SLE were analyzed, with special emphasis on their clinical, laboratory, and serologic features. Data from 50 patients with SLE and 50 patients with SS served as control subjects. The mean age in SS-SLE group was lower than in patients with SS but higher than patients with SLE. When SLE and SS were associated, presence of rheumatoid factor was less frequent, whereas anti-Ro/SS-A, anti-La/SS-B, antinuclear, anti-DNA, and antiphospholipid autoantibodies appeared more often. Antiphospholipid syndrome, anemia, leucopenia, and lymphopenia were more frequent in the associated disease than in patients with SS alone. In SS-SLE patients, pulmonary, renal, skin, central nervous system involvement, and serositis occurred more often than in patients with SS alone. Thyroiditis, autoantibodies to Ro/SS-A, La/SS-B and ds-DNA was more frequent in the SS-SLE group than in patients with SLE. Genetic background of the patients did not differ significantly. In conclusion, characteristic clinical, laboratory and serologic features distinguish between the association of SS and SLE and the primary forms of these two diseases. SN - 0198-8859 UR - https://www.unboundmedicine.com/medline/citation/17145372/Clinical_serologic_and_genetic_profiles_of_patients_with_associated_Sjögren's_syndrome_and_systemic_lupus_erythematosus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(06)00164-9 DB - PRIME DP - Unbound Medicine ER -