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Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity.
Gynecol Endocrinol 2006; 22(11):651-4GE

Abstract

The present study aimed to assess the fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome (PCOS) and to compare them in obese PCOS patients and women with simple obesity. We studied 19 obese women with PCOS (age: 25.1 +/- 4.6 years, body mass index (BMI): 34.7 +/- 3.9 kg/m2; mean +/- standard deviation) and 20 age- and BMI-matched ovulatory controls. We measured blood levels of 17beta-estradiol, testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose and insulin. The following fibrinolytic tests were also performed: euglobulin clot lysis time, plasminogen level, alpha2-antiplasmin activity, plasminogen activator inhibitor-1 activity, fibrinogen concentration and estimated fibrinolytic activity. Testosterone and LH levels were significantly higher in obese women with PCOS (p < 0.01 and p < 0.001, respectively). The groups did not differ with regard to 17beta-estradiol, prolactin, FSH, DHEAS, TC, TG, HDL-C, LDL-C, glucose and insulin. All of the fibrinolysis parameters with the exception of plasminogen were comparable between the two groups. Serum plasminogen level was lower in obese PCOS patients than in women with simple obesity (p < 0.05). Euglobulin clot lysis time was positively correlated with insulin (r = 0.88, p < 0.05) in both groups. Our results show that fibrinolysis is not suppressed in women with PCOS and that there is no difference in fibrinolytic activity between obese patients with PCOS and women with simple obesity.

Authors+Show Affiliations

Department of Gynecological Endocrinology, University of Medical Sciences of Poznań, Poznań, Poland.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17145652

Citation

Słopień, R, et al. "Comparison of Fibrinolytic and Metabolic System Parameters in Obese Patients With Polycystic Ovary Syndrome and Women With Simple Obesity." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 22, no. 11, 2006, pp. 651-4.
Słopień R, Lewandowski K, Kolacz E, et al. Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity. Gynecol Endocrinol. 2006;22(11):651-4.
Słopień, R., Lewandowski, K., Kolacz, E., Zawilska, K., & Warenik-Szymankiewicz, A. (2006). Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 22(11), pp. 651-4.
Słopień R, et al. Comparison of Fibrinolytic and Metabolic System Parameters in Obese Patients With Polycystic Ovary Syndrome and Women With Simple Obesity. Gynecol Endocrinol. 2006;22(11):651-4. PubMed PMID: 17145652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity. AU - Słopień,R, AU - Lewandowski,K, AU - Kolacz,E, AU - Zawilska,K, AU - Warenik-Szymankiewicz,A, PY - 2006/12/6/pubmed PY - 2007/4/5/medline PY - 2006/12/6/entrez SP - 651 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 22 IS - 11 N2 - The present study aimed to assess the fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome (PCOS) and to compare them in obese PCOS patients and women with simple obesity. We studied 19 obese women with PCOS (age: 25.1 +/- 4.6 years, body mass index (BMI): 34.7 +/- 3.9 kg/m2; mean +/- standard deviation) and 20 age- and BMI-matched ovulatory controls. We measured blood levels of 17beta-estradiol, testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose and insulin. The following fibrinolytic tests were also performed: euglobulin clot lysis time, plasminogen level, alpha2-antiplasmin activity, plasminogen activator inhibitor-1 activity, fibrinogen concentration and estimated fibrinolytic activity. Testosterone and LH levels were significantly higher in obese women with PCOS (p < 0.01 and p < 0.001, respectively). The groups did not differ with regard to 17beta-estradiol, prolactin, FSH, DHEAS, TC, TG, HDL-C, LDL-C, glucose and insulin. All of the fibrinolysis parameters with the exception of plasminogen were comparable between the two groups. Serum plasminogen level was lower in obese PCOS patients than in women with simple obesity (p < 0.05). Euglobulin clot lysis time was positively correlated with insulin (r = 0.88, p < 0.05) in both groups. Our results show that fibrinolysis is not suppressed in women with PCOS and that there is no difference in fibrinolytic activity between obese patients with PCOS and women with simple obesity. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/17145652/Comparison_of_fibrinolytic_and_metabolic_system_parameters_in_obese_patients_with_polycystic_ovary_syndrome_and_women_with_simple_obesity_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590601005805 DB - PRIME DP - Unbound Medicine ER -