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In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains.
Mycopathologia. 2006 Dec; 162(6):395-400.M

Abstract

The aim of this study was to determine the in vitro fungicidal and growth inhibitory activity of ciclopirox olamine alone (1% and 1.5%) or in association with 1% zinc pyrithione compared to 2% ketoconazole, against Malassezia species particularly involved in the pathogenesis of seborrheic dermatitis. Experiments were performed on Malassezia globosa IP 2387.96 and M. restricta IP 2392.96 strains. Growth inhibitory activity of the active compounds in solution was evaluated by measuring minimal inhibitory concentrations using a broth micro-method and their fungicidal activity by a filtration method after contact times between solutions and yeasts ranging from 3-5 to 30 min. Concerning the determination of minimal inhibitory concentration of ciclopirox olamine/zinc pyrithione, it revealed the marked synergistic inhibitory effect of the association, leading to a higher efficacy compared to ketoconazole. As to the fungicidal activity of ciclopirox olamine, it significantly increased with the contact time. After 15-30 min of contact between 1.5% ciclopirox olamine and Malassezia strains, a 2-log reduction of Malassezia counts was observed. The 1.5% ciclopirox olamine/1% zinc pyrithione association was characterized by a steady fungicidal efficacy whereas the 2% ketoconazole solution did not express any fungicidal effect. In conclusion, this study demonstrates the in vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species and underscores its potential interest in the treatment of seborrheic dermatitis.

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Authors+Show Affiliations

Roques C
Faculty of Pharmaceutical Sciences, FONDEREPHAR, Toulouse, France. christine.roques@cict.fr
Brousse S
No affiliation info available
Panizzutti C
No affiliation info available

MeSH

Antifungal AgentsCiclopiroxDermatitis, SeborrheicDrug Therapy, CombinationHair PreparationsKetoconazoleMalasseziaMicrobial Sensitivity TestsOrganometallic CompoundsPyridinesPyridones

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17146583

Citation

Roques, Christine, et al. "In Vitro Antifungal Efficacy of Ciclopirox Olamine Alone and Associated With Zinc Pyrithione Compared to Ketoconazole Against Malassezia Globosa and Malassezia Restricta Reference Strains." Mycopathologia, vol. 162, no. 6, 2006, pp. 395-400.
Roques C, Brousse S, Panizzutti C. In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains. Mycopathologia. 2006;162(6):395-400.
Roques, C., Brousse, S., & Panizzutti, C. (2006). In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains. Mycopathologia, 162(6), 395-400.
Roques C, Brousse S, Panizzutti C. In Vitro Antifungal Efficacy of Ciclopirox Olamine Alone and Associated With Zinc Pyrithione Compared to Ketoconazole Against Malassezia Globosa and Malassezia Restricta Reference Strains. Mycopathologia. 2006;162(6):395-400. PubMed PMID: 17146583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains. AU - Roques,Christine, AU - Brousse,Sabine, AU - Panizzutti,Cédric, PY - 2006/02/20/received PY - 2006/10/04/accepted PY - 2006/12/6/pubmed PY - 2007/2/28/medline PY - 2006/12/6/entrez SP - 395 EP - 400 JF - Mycopathologia JO - Mycopathologia VL - 162 IS - 6 N2 - The aim of this study was to determine the in vitro fungicidal and growth inhibitory activity of ciclopirox olamine alone (1% and 1.5%) or in association with 1% zinc pyrithione compared to 2% ketoconazole, against Malassezia species particularly involved in the pathogenesis of seborrheic dermatitis. Experiments were performed on Malassezia globosa IP 2387.96 and M. restricta IP 2392.96 strains. Growth inhibitory activity of the active compounds in solution was evaluated by measuring minimal inhibitory concentrations using a broth micro-method and their fungicidal activity by a filtration method after contact times between solutions and yeasts ranging from 3-5 to 30 min. Concerning the determination of minimal inhibitory concentration of ciclopirox olamine/zinc pyrithione, it revealed the marked synergistic inhibitory effect of the association, leading to a higher efficacy compared to ketoconazole. As to the fungicidal activity of ciclopirox olamine, it significantly increased with the contact time. After 15-30 min of contact between 1.5% ciclopirox olamine and Malassezia strains, a 2-log reduction of Malassezia counts was observed. The 1.5% ciclopirox olamine/1% zinc pyrithione association was characterized by a steady fungicidal efficacy whereas the 2% ketoconazole solution did not express any fungicidal effect. In conclusion, this study demonstrates the in vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species and underscores its potential interest in the treatment of seborrheic dermatitis. SN - 0301-486X UR - https://www.unboundmedicine.com/medline/citation/17146583/In_vitro_antifungal_efficacy_of_ciclopirox_olamine_alone_and_associated_with_zinc_pyrithione_compared_to_ketoconazole_against_Malassezia_globosa_and_Malassezia_restricta_reference_strains_ L2 - https://dx.doi.org/10.1007/s11046-006-0075-0 DB - PRIME DP - Unbound Medicine ER -