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Hydroxyethylstarch 200 and 240 differently affect aortic distensibility but not viscosity and blood pressure upon acute isovolumic hemodilution.
Clin Hemorheol Microcirc. 2006; 35(4):447-58.CH

Abstract

OBJECTIVES

It has been shown that a hydroxyethylstarch solution significantly increases the aortic distensibility coefficient (ADC) as compared to other non-hydroxyethylstarch colloid solutions. In order to investigate whether the effect of hydroxyethylstarch on ADC is class-specific, we investigated the effect of two hydroxyethylstarch solutions (HES 200: Elohes and HES 240: Hesteril) on the ADC and compared them with two other colloid solutions: 5% albumin and fluid gelatin (Gelofusin) in a rabbit model of acute isovolumic hemodilution.

METHODS

Twenty-eight male New Zealand white rabbits were anesthetized and randomly allocated to receive (n=7, each): albumin, hydroxyethylstarch-200, hydroxyethylstarch-240 and gelatin for acute isovolumic hemodilution by exchanging 13 ml.kg(-1) body weight of blood with an identical volume of the test solution. Blood viscosity, mean arterial pressure, aortic blood flow and heart rate were measured and ADC was calculated.

RESULTS

All groups were comparable with respect to arterial pressure, heart rate and aortic blood flow velocity before and after isovolumic hemodilution. After hemodilution, ADC coefficient remained unchanged as compared with pre-hemodilution values with albumin, hydroxyethylstarch-240 and gelatin, whereas a sustained 3 fold increase was observed with hydroxyethylstarch-200.

CONCLUSION

These results demonstrate that minor physicochemical differences between two hydroxyethylstarch solutions result in measurable differences in ADC and suggest that the clinical effects of colloids should probably be analyzed for each type of colloid and not for classes of colloids (e.g. hydroxyethylstarch or fluid gelatins).

Authors+Show Affiliations

Laboratory of Hematology and Physiology, EA 3452, Faculty of Pharmacy, University Henri Poincaré, Nancy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17148843

Citation

Caron, Alexis, et al. "Hydroxyethylstarch 200 and 240 Differently Affect Aortic Distensibility but Not Viscosity and Blood Pressure Upon Acute Isovolumic Hemodilution." Clinical Hemorheology and Microcirculation, vol. 35, no. 4, 2006, pp. 447-58.
Caron A, Hacquard M, Audibert G, et al. Hydroxyethylstarch 200 and 240 differently affect aortic distensibility but not viscosity and blood pressure upon acute isovolumic hemodilution. Clin Hemorheol Microcirc. 2006;35(4):447-58.
Caron, A., Hacquard, M., Audibert, G., Cauchois, G., Vigneron, C., Stoltz, J. F., Longrois, D., & Menu, P. (2006). Hydroxyethylstarch 200 and 240 differently affect aortic distensibility but not viscosity and blood pressure upon acute isovolumic hemodilution. Clinical Hemorheology and Microcirculation, 35(4), 447-58.
Caron A, et al. Hydroxyethylstarch 200 and 240 Differently Affect Aortic Distensibility but Not Viscosity and Blood Pressure Upon Acute Isovolumic Hemodilution. Clin Hemorheol Microcirc. 2006;35(4):447-58. PubMed PMID: 17148843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyethylstarch 200 and 240 differently affect aortic distensibility but not viscosity and blood pressure upon acute isovolumic hemodilution. AU - Caron,Alexis, AU - Hacquard,Marie, AU - Audibert,Gérard, AU - Cauchois,Ghislaine, AU - Vigneron,Claude, AU - Stoltz,Jean-François, AU - Longrois,Dan, AU - Menu,Patrick, PY - 2006/12/7/pubmed PY - 2007/3/14/medline PY - 2006/12/7/entrez SP - 447 EP - 58 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 35 IS - 4 N2 - OBJECTIVES: It has been shown that a hydroxyethylstarch solution significantly increases the aortic distensibility coefficient (ADC) as compared to other non-hydroxyethylstarch colloid solutions. In order to investigate whether the effect of hydroxyethylstarch on ADC is class-specific, we investigated the effect of two hydroxyethylstarch solutions (HES 200: Elohes and HES 240: Hesteril) on the ADC and compared them with two other colloid solutions: 5% albumin and fluid gelatin (Gelofusin) in a rabbit model of acute isovolumic hemodilution. METHODS: Twenty-eight male New Zealand white rabbits were anesthetized and randomly allocated to receive (n=7, each): albumin, hydroxyethylstarch-200, hydroxyethylstarch-240 and gelatin for acute isovolumic hemodilution by exchanging 13 ml.kg(-1) body weight of blood with an identical volume of the test solution. Blood viscosity, mean arterial pressure, aortic blood flow and heart rate were measured and ADC was calculated. RESULTS: All groups were comparable with respect to arterial pressure, heart rate and aortic blood flow velocity before and after isovolumic hemodilution. After hemodilution, ADC coefficient remained unchanged as compared with pre-hemodilution values with albumin, hydroxyethylstarch-240 and gelatin, whereas a sustained 3 fold increase was observed with hydroxyethylstarch-200. CONCLUSION: These results demonstrate that minor physicochemical differences between two hydroxyethylstarch solutions result in measurable differences in ADC and suggest that the clinical effects of colloids should probably be analyzed for each type of colloid and not for classes of colloids (e.g. hydroxyethylstarch or fluid gelatins). SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/17148843/Hydroxyethylstarch_200_and_240_differently_affect_aortic_distensibility_but_not_viscosity_and_blood_pressure_upon_acute_isovolumic_hemodilution_ L2 - https://content.iospress.com/openurl?genre=article&issn=1386-0291&volume=35&issue=4&spage=447 DB - PRIME DP - Unbound Medicine ER -