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Breathing pattern adopted by children with cystic fibrosis with mild to moderate pulmonary impairment during exercise.
Respiration 2008; 75(2):170-7R

Abstract

BACKGROUND

It is well known that severe lung impairment in cystic fibrosis (CF) may compromise respiratory muscle function at rest. Even though patients with CF and severe obstructive lung disease exhibit an abnormal breathing pattern during exercise (due to expiratory flow limitation), patients with CF and normal lung function reportedly have a normal breathing pattern.

OBJECTIVES

The aim of the study was to assess the precise characteristics of the ventilatory pattern adopted during exercise by children with CF and mild to moderate lung disease.

METHODS

Nine children diagnosed as having mild to moderate CF and 9 healthy children with a similar age distribution participated in this study. Both groups performed a continuous incremental cycling protocol. Breathing and timing components were assessed during exercise.

RESULTS

Differences in the breathing pattern between children with CF and controls during exercise are illustrated in Hey plot which described a rapid shallow breathing pattern in children with CF. During exercise, children with CF showed a significantly lower mean inspiratory flow than healthy children (p < 0.001), whereas the mean expiratory flow was higher (p < 0.001). Children with CF also showed a significant increase in the end-tidal carbon dioxide pressure, which may indicate the emergence of hypercapnia.

CONCLUSIONS

During exercise, children with CF (even those not suffering from advanced disease) showed signs of rapid, shallow breathing and an increase in the ventilatory response. This was essentially due to an increase in the mean inspiratory flow, which in turn suggests an expiratory flow limitation. The children were also predisposed to hypercapnia.

Authors+Show Affiliations

EA 3300, APS et Conduites Motrices: Adaptations et Réadaptations, Faculté des Sciences du Sport, Université Picardie Jules Verne, Amiens, France. david.keochkerian@u-picardie.fr

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17148933

Citation

Keochkerian, David, et al. "Breathing Pattern Adopted By Children With Cystic Fibrosis With Mild to Moderate Pulmonary Impairment During Exercise." Respiration; International Review of Thoracic Diseases, vol. 75, no. 2, 2008, pp. 170-7.
Keochkerian D, Chlif M, Delanaud S, et al. Breathing pattern adopted by children with cystic fibrosis with mild to moderate pulmonary impairment during exercise. Respiration. 2008;75(2):170-7.
Keochkerian, D., Chlif, M., Delanaud, S., Gauthier, R., Maingourd, Y., & Ahmaidi, S. (2008). Breathing pattern adopted by children with cystic fibrosis with mild to moderate pulmonary impairment during exercise. Respiration; International Review of Thoracic Diseases, 75(2), pp. 170-7.
Keochkerian D, et al. Breathing Pattern Adopted By Children With Cystic Fibrosis With Mild to Moderate Pulmonary Impairment During Exercise. Respiration. 2008;75(2):170-7. PubMed PMID: 17148933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breathing pattern adopted by children with cystic fibrosis with mild to moderate pulmonary impairment during exercise. AU - Keochkerian,David, AU - Chlif,Mehdi, AU - Delanaud,Stéphane, AU - Gauthier,Rémi, AU - Maingourd,Yves, AU - Ahmaidi,Said, Y1 - 2006/12/04/ PY - 2005/09/07/received PY - 2006/09/20/accepted PY - 2006/12/7/pubmed PY - 2008/5/31/medline PY - 2006/12/7/entrez SP - 170 EP - 7 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 75 IS - 2 N2 - BACKGROUND: It is well known that severe lung impairment in cystic fibrosis (CF) may compromise respiratory muscle function at rest. Even though patients with CF and severe obstructive lung disease exhibit an abnormal breathing pattern during exercise (due to expiratory flow limitation), patients with CF and normal lung function reportedly have a normal breathing pattern. OBJECTIVES: The aim of the study was to assess the precise characteristics of the ventilatory pattern adopted during exercise by children with CF and mild to moderate lung disease. METHODS: Nine children diagnosed as having mild to moderate CF and 9 healthy children with a similar age distribution participated in this study. Both groups performed a continuous incremental cycling protocol. Breathing and timing components were assessed during exercise. RESULTS: Differences in the breathing pattern between children with CF and controls during exercise are illustrated in Hey plot which described a rapid shallow breathing pattern in children with CF. During exercise, children with CF showed a significantly lower mean inspiratory flow than healthy children (p < 0.001), whereas the mean expiratory flow was higher (p < 0.001). Children with CF also showed a significant increase in the end-tidal carbon dioxide pressure, which may indicate the emergence of hypercapnia. CONCLUSIONS: During exercise, children with CF (even those not suffering from advanced disease) showed signs of rapid, shallow breathing and an increase in the ventilatory response. This was essentially due to an increase in the mean inspiratory flow, which in turn suggests an expiratory flow limitation. The children were also predisposed to hypercapnia. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/17148933/Breathing_pattern_adopted_by_children_with_cystic_fibrosis_with_mild_to_moderate_pulmonary_impairment_during_exercise_ L2 - https://www.karger.com?DOI=10.1159/000097772 DB - PRIME DP - Unbound Medicine ER -