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Seizures during treatment of Vitamin B12 deficiency.
Seizure. 2007 Jan; 16(1):69-73.S

Abstract

Epileptic seizures during infancy have a wide variety of clinical presentations and the outcome differs according to the etiology. Among the benign and rare causes of infantile seizures, Vitamin B12 deficiency has been encountered. Common symptoms of Vitamin B12 deficiency in infants include megaloblastic anemia, feeding difficulties, developmental delay, microcephaly, failure to thrive, hypotonia, lethargy, irritability, involuntary movements, seizures and cerebral atrophy. Involuntary movements and seizures may rarely be the initial symptoms of Vitamin B12 deficiency. Involuntary movements have also been reported to appear after initiation of Vitamin B12 supplementation in isolated cases, whereas, no such information exits for seizures. In this paper, three infants with Vitamin B12 deficiency associated with motor and mental retardation are reported because of long-lasting focal/multifocal epileptic seizures following the initiation of intramuscular Vitamin B12 treatment. Antiepileptics were introduced in addition to Vitamin B12. Seizures disappeared within a few days or weeks; electroencephalographic findings were normalized in a few months. No relapses occurred during the follow-up period.

Authors+Show Affiliations

Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17150378

Citation

Benbir, G, et al. "Seizures During Treatment of Vitamin B12 Deficiency." Seizure, vol. 16, no. 1, 2007, pp. 69-73.
Benbir G, Uysal S, Saltik S, et al. Seizures during treatment of Vitamin B12 deficiency. Seizure. 2007;16(1):69-73.
Benbir, G., Uysal, S., Saltik, S., Zeybek, C. A., Aydin, A., Dervent, A., & Yalcinkaya, C. (2007). Seizures during treatment of Vitamin B12 deficiency. Seizure, 16(1), 69-73.
Benbir G, et al. Seizures During Treatment of Vitamin B12 Deficiency. Seizure. 2007;16(1):69-73. PubMed PMID: 17150378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seizures during treatment of Vitamin B12 deficiency. AU - Benbir,G, AU - Uysal,S, AU - Saltik,S, AU - Zeybek,C Aktuglu, AU - Aydin,A, AU - Dervent,A, AU - Yalcinkaya,C, Y1 - 2006/12/05/ PY - 2005/03/03/received PY - 2005/09/12/revised PY - 2006/10/31/accepted PY - 2006/12/8/pubmed PY - 2007/3/23/medline PY - 2006/12/8/entrez SP - 69 EP - 73 JF - Seizure JO - Seizure VL - 16 IS - 1 N2 - Epileptic seizures during infancy have a wide variety of clinical presentations and the outcome differs according to the etiology. Among the benign and rare causes of infantile seizures, Vitamin B12 deficiency has been encountered. Common symptoms of Vitamin B12 deficiency in infants include megaloblastic anemia, feeding difficulties, developmental delay, microcephaly, failure to thrive, hypotonia, lethargy, irritability, involuntary movements, seizures and cerebral atrophy. Involuntary movements and seizures may rarely be the initial symptoms of Vitamin B12 deficiency. Involuntary movements have also been reported to appear after initiation of Vitamin B12 supplementation in isolated cases, whereas, no such information exits for seizures. In this paper, three infants with Vitamin B12 deficiency associated with motor and mental retardation are reported because of long-lasting focal/multifocal epileptic seizures following the initiation of intramuscular Vitamin B12 treatment. Antiepileptics were introduced in addition to Vitamin B12. Seizures disappeared within a few days or weeks; electroencephalographic findings were normalized in a few months. No relapses occurred during the follow-up period. SN - 1059-1311 UR - https://www.unboundmedicine.com/medline/citation/17150378/Seizures_during_treatment_of_Vitamin_B12_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1059-1311(06)00203-2 DB - PRIME DP - Unbound Medicine ER -