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Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study.
Am J Psychiatry 2006; 163(12):2103-10AJ

Abstract

OBJECTIVE

Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior temporal gyrus and the amygdala-hippocampal complex. However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia.

METHOD

High-spatial-resolution MRI was used to measure gray matter volume in the inferior, middle, and superior temporal gyri in 20 patients with first-episode schizophrenia, 20 patients with first-episode affective psychosis, and 23 healthy comparison subjects.

RESULTS

Gray matter volume in the middle temporal gyrus was smaller bilaterally in patients with first-episode schizophrenia than in comparison subjects and in patients with first-episode affective psychosis. Posterior gray matter volume in the inferior temporal gyrus was smaller bilaterally in both patient groups than in comparison subjects. Among the superior, middle, and inferior temporal gyri, the left posterior superior temporal gyrus gray matter in the schizophrenia group had the smallest volume, the greatest percentage difference, and the largest effect size in comparisons with healthy comparison subjects and with affective psychosis patients.

CONCLUSIONS

Smaller gray matter volumes in the left and right middle temporal gyri and left posterior superior temporal gyrus were present in schizophrenia but not in affective psychosis at first hospitalization. In contrast, smaller bilateral posterior inferior temporal gyrus gray matter volume is present in both schizophrenia and affective psychosis at first hospitalization. These findings suggest that smaller gray matter volumes in the dorsal temporal lobe (superior and middle temporal gyri) may be specific to schizophrenia, whereas smaller posterior inferior temporal gyrus gray matter volumes may be related to pathology common to both schizophrenia and affective psychosis.

Authors+Show Affiliations

Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17151161

Citation

Kuroki, Noriomi, et al. "Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in First-episode Schizophrenia: an MRI Study." The American Journal of Psychiatry, vol. 163, no. 12, 2006, pp. 2103-10.
Kuroki N, Shenton ME, Salisbury DF, et al. Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. Am J Psychiatry. 2006;163(12):2103-10.
Kuroki, N., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Onitsuka, T., Ersner-Hershfield, H., ... McCarley, R. W. (2006). Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. The American Journal of Psychiatry, 163(12), pp. 2103-10.
Kuroki N, et al. Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in First-episode Schizophrenia: an MRI Study. Am J Psychiatry. 2006;163(12):2103-10. PubMed PMID: 17151161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. AU - Kuroki,Noriomi, AU - Shenton,Martha E, AU - Salisbury,Dean F, AU - Hirayasu,Yoshio, AU - Onitsuka,Toshiaki, AU - Ersner-Hershfield,Hal, AU - Yurgelun-Todd,Deborah, AU - Kikinis,Ron, AU - Jolesz,Ferenc A, AU - McCarley,Robert W, PY - 2006/12/8/pubmed PY - 2007/2/17/medline PY - 2006/12/8/entrez SP - 2103 EP - 10 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 163 IS - 12 N2 - OBJECTIVE: Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior temporal gyrus and the amygdala-hippocampal complex. However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia. METHOD: High-spatial-resolution MRI was used to measure gray matter volume in the inferior, middle, and superior temporal gyri in 20 patients with first-episode schizophrenia, 20 patients with first-episode affective psychosis, and 23 healthy comparison subjects. RESULTS: Gray matter volume in the middle temporal gyrus was smaller bilaterally in patients with first-episode schizophrenia than in comparison subjects and in patients with first-episode affective psychosis. Posterior gray matter volume in the inferior temporal gyrus was smaller bilaterally in both patient groups than in comparison subjects. Among the superior, middle, and inferior temporal gyri, the left posterior superior temporal gyrus gray matter in the schizophrenia group had the smallest volume, the greatest percentage difference, and the largest effect size in comparisons with healthy comparison subjects and with affective psychosis patients. CONCLUSIONS: Smaller gray matter volumes in the left and right middle temporal gyri and left posterior superior temporal gyrus were present in schizophrenia but not in affective psychosis at first hospitalization. In contrast, smaller bilateral posterior inferior temporal gyrus gray matter volume is present in both schizophrenia and affective psychosis at first hospitalization. These findings suggest that smaller gray matter volumes in the dorsal temporal lobe (superior and middle temporal gyri) may be specific to schizophrenia, whereas smaller posterior inferior temporal gyrus gray matter volumes may be related to pathology common to both schizophrenia and affective psychosis. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/17151161/Middle_and_inferior_temporal_gyrus_gray_matter_volume_abnormalities_in_first_episode_schizophrenia:_an_MRI_study_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2006.163.12.2103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -