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Interaction of 5-azacytidine and dexamethasone in the control of hepatic tyrosine aminotransferase.
Adv Enzyme Regul. 1991; 31:247-58.AE

Abstract

The nucleoside analog 5-azacytidine is able to induce tyrosine aminotransferase several-fold in the liver of suckling rats. Bilateral adrenalectomy abolishes this inducing effect. The drug also decreases significantly the concentration of cytosolic glucocorticoid receptor accompanied by an increase of the glucocorticoid receptor concentration in the nuclei. The antiglucocorticoid RU 486 which abolishes the induction of tyrosine aminotransferase and serine dehydratase by dexamethasone very effectively is not able to inhibit either the induction of tyrosine aminotransferase or the translocation of the glucocorticoid receptor into the nuclei by 5-azacytidine.

Authors+Show Affiliations

Schulze A
Institute of Biochemistry, University of Leipzig School of Medicine, Germany.
Böhme HJ
No affiliation info available
Goltzsch W
No affiliation info available
Hofmann E
No affiliation info available

MeSH

AnimalsAzacitidineDexamethasoneEnzyme InductionL-Serine DehydrataseLiverRatsRats, Inbred StrainsReceptors, GlucocorticoidTyrosine Transaminase

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1715117

Citation

Schulze, A, et al. "Interaction of 5-azacytidine and Dexamethasone in the Control of Hepatic Tyrosine Aminotransferase." Advances in Enzyme Regulation, vol. 31, 1991, pp. 247-58.
Schulze A, Böhme HJ, Goltzsch W, et al. Interaction of 5-azacytidine and dexamethasone in the control of hepatic tyrosine aminotransferase. Adv Enzyme Regul. 1991;31:247-58.
Schulze, A., Böhme, H. J., Goltzsch, W., & Hofmann, E. (1991). Interaction of 5-azacytidine and dexamethasone in the control of hepatic tyrosine aminotransferase. Advances in Enzyme Regulation, 31, 247-58.
Schulze A, et al. Interaction of 5-azacytidine and Dexamethasone in the Control of Hepatic Tyrosine Aminotransferase. Adv Enzyme Regul. 1991;31:247-58. PubMed PMID: 1715117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of 5-azacytidine and dexamethasone in the control of hepatic tyrosine aminotransferase. AU - Schulze,A, AU - Böhme,H J, AU - Goltzsch,W, AU - Hofmann,E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 247 EP - 58 JF - Advances in enzyme regulation JO - Adv Enzyme Regul VL - 31 N2 - The nucleoside analog 5-azacytidine is able to induce tyrosine aminotransferase several-fold in the liver of suckling rats. Bilateral adrenalectomy abolishes this inducing effect. The drug also decreases significantly the concentration of cytosolic glucocorticoid receptor accompanied by an increase of the glucocorticoid receptor concentration in the nuclei. The antiglucocorticoid RU 486 which abolishes the induction of tyrosine aminotransferase and serine dehydratase by dexamethasone very effectively is not able to inhibit either the induction of tyrosine aminotransferase or the translocation of the glucocorticoid receptor into the nuclei by 5-azacytidine. SN - 0065-2571 UR - https://www.unboundmedicine.com/medline/citation/1715117/Interaction_of_5_azacytidine_and_dexamethasone_in_the_control_of_hepatic_tyrosine_aminotransferase_ DB - PRIME DP - Unbound Medicine ER -