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Diabetic neuropathy differs in type 1 and type 2 diabetes.
Ann N Y Acad Sci 2006; 1084:235-49AN

Abstract

In this article we describe differences in early metabolic abnormalities between type 1 and type 2 diabetic polyneuropathy (DPN), and how these differences lead to milder initial functional defects in type 2 diabetes, despite the same hyperglycemic exposures. This early reversible metabolic phase is progressively overshadowed by structural degenerative changes eventually resulting in nerve fiber loss. In comparison, the late structural phase of DPN affects type 1 diabetes more severely. Progressive axonal atrophy and loss is hence expressed to a larger extent in type 1 diabetes. In addition, type 1 DPN is characterized by paranodal degenerative changes not seen in type 2 DPN. These differences can be related to the differences in insulin action and signal transduction affecting the expression of neurotrophic factors and their receptors in type 1 diabetes. Downstream effects on neuroskeletal and adhesive proteins, their posttranslational modifications, and nociceptive peptides underlie the more severe resultant pathology in type 1 DPN. These differences in underlying mechanisms should be seriously considered in the future design of interventional paradigms to combat these common conditions.

Authors+Show Affiliations

Department of Pathology, Wayne State University, 540 E. Canfield Ave. Detroit, MI 48201, USA. asima@med.wayne.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17151305

Citation

Sima, Anders A F., and Hideki Kamiya. "Diabetic Neuropathy Differs in Type 1 and Type 2 Diabetes." Annals of the New York Academy of Sciences, vol. 1084, 2006, pp. 235-49.
Sima AA, Kamiya H. Diabetic neuropathy differs in type 1 and type 2 diabetes. Ann N Y Acad Sci. 2006;1084:235-49.
Sima, A. A., & Kamiya, H. (2006). Diabetic neuropathy differs in type 1 and type 2 diabetes. Annals of the New York Academy of Sciences, 1084, pp. 235-49.
Sima AA, Kamiya H. Diabetic Neuropathy Differs in Type 1 and Type 2 Diabetes. Ann N Y Acad Sci. 2006;1084:235-49. PubMed PMID: 17151305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic neuropathy differs in type 1 and type 2 diabetes. AU - Sima,Anders A F, AU - Kamiya,Hideki, PY - 2006/12/8/pubmed PY - 2007/3/23/medline PY - 2006/12/8/entrez SP - 235 EP - 49 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1084 N2 - In this article we describe differences in early metabolic abnormalities between type 1 and type 2 diabetic polyneuropathy (DPN), and how these differences lead to milder initial functional defects in type 2 diabetes, despite the same hyperglycemic exposures. This early reversible metabolic phase is progressively overshadowed by structural degenerative changes eventually resulting in nerve fiber loss. In comparison, the late structural phase of DPN affects type 1 diabetes more severely. Progressive axonal atrophy and loss is hence expressed to a larger extent in type 1 diabetes. In addition, type 1 DPN is characterized by paranodal degenerative changes not seen in type 2 DPN. These differences can be related to the differences in insulin action and signal transduction affecting the expression of neurotrophic factors and their receptors in type 1 diabetes. Downstream effects on neuroskeletal and adhesive proteins, their posttranslational modifications, and nociceptive peptides underlie the more severe resultant pathology in type 1 DPN. These differences in underlying mechanisms should be seriously considered in the future design of interventional paradigms to combat these common conditions. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/17151305/Diabetic_neuropathy_differs_in_type_1_and_type_2_diabetes_ L2 - https://doi.org/10.1196/annals.1372.004 DB - PRIME DP - Unbound Medicine ER -