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Predictors of non-alcoholic fatty liver disease in obese children.
Eur J Clin Nutr. 2007 Jul; 61(7):877-83.EJ

Abstract

OBJECTIVE

To evaluate predictors of non-alcoholic fatty liver disease (NAFLD) in obese children.

DESIGN

Cross-sectional study.

SUBJECTS

Two hundred and sixty-eight obese children not consuming alcohol and without hepatitis B or C were consecutively studied at an auxology clinic.

MEASUREMENTS

Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl-transferase (GGT), cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides, uric acid, glucose, glucose during oral glucose tolerance testing (OGTT), insulin, insulin during OGTT, insulin resistance as estimated by homeostasis model assessment (HOMA), C-reactive protein (CRP), and systolic and diastolic blood pressure were measured. Fatty liver was diagnosed by ultrasonography using standard criteria. Univariable and multivariable logistic regression was used to evaluate predictors of NAFLD. All predictors except gender and pubertal status were modeled as continuous variables.

RESULTS

NAFLD was detected in 44% of obese children. At univariable analysis, male gender, Z-score of body mass index (BMI) (Z-BMI), ALT, AST, GGT, triglycerides, uric acid, glucose, glucose during OGTT, insulin, insulin during OGTT, HOMA, CRP and systolic blood pressure were predictors of NAFLD, whereas HDL-cholesterol and late-pubertal status were predictors of the normal liver. At multivariable analysis, however, only Z-BMI, ALT, uric acid, glucose during OGTT and insulin during OGTT were independent predictors of NAFLD.

CONCLUSION

Z-BMI, ALT, uric acid, glucose during OGTT and insulin during OGTT are independent predictors of NAFLD in Italian obese children, with most of the prediction explained by ALT and Z-BMI.

Authors+Show Affiliations

Divisione di Auxologia e Laboratorio Sperimentale di Ricerche Auxo-endocrinologiche, Istituto Auxologico Italiano, IRCCS, Verbania and Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17151586

Citation

Sartorio, A, et al. "Predictors of Non-alcoholic Fatty Liver Disease in Obese Children." European Journal of Clinical Nutrition, vol. 61, no. 7, 2007, pp. 877-83.
Sartorio A, Del Col A, Agosti F, et al. Predictors of non-alcoholic fatty liver disease in obese children. Eur J Clin Nutr. 2007;61(7):877-83.
Sartorio, A., Del Col, A., Agosti, F., Mazzilli, G., Bellentani, S., Tiribelli, C., & Bedogni, G. (2007). Predictors of non-alcoholic fatty liver disease in obese children. European Journal of Clinical Nutrition, 61(7), 877-83.
Sartorio A, et al. Predictors of Non-alcoholic Fatty Liver Disease in Obese Children. Eur J Clin Nutr. 2007;61(7):877-83. PubMed PMID: 17151586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of non-alcoholic fatty liver disease in obese children. AU - Sartorio,A, AU - Del Col,A, AU - Agosti,F, AU - Mazzilli,G, AU - Bellentani,S, AU - Tiribelli,C, AU - Bedogni,G, Y1 - 2006/12/06/ PY - 2006/12/8/pubmed PY - 2007/9/5/medline PY - 2006/12/8/entrez SP - 877 EP - 83 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 7 N2 - OBJECTIVE: To evaluate predictors of non-alcoholic fatty liver disease (NAFLD) in obese children. DESIGN: Cross-sectional study. SUBJECTS: Two hundred and sixty-eight obese children not consuming alcohol and without hepatitis B or C were consecutively studied at an auxology clinic. MEASUREMENTS: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl-transferase (GGT), cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides, uric acid, glucose, glucose during oral glucose tolerance testing (OGTT), insulin, insulin during OGTT, insulin resistance as estimated by homeostasis model assessment (HOMA), C-reactive protein (CRP), and systolic and diastolic blood pressure were measured. Fatty liver was diagnosed by ultrasonography using standard criteria. Univariable and multivariable logistic regression was used to evaluate predictors of NAFLD. All predictors except gender and pubertal status were modeled as continuous variables. RESULTS: NAFLD was detected in 44% of obese children. At univariable analysis, male gender, Z-score of body mass index (BMI) (Z-BMI), ALT, AST, GGT, triglycerides, uric acid, glucose, glucose during OGTT, insulin, insulin during OGTT, HOMA, CRP and systolic blood pressure were predictors of NAFLD, whereas HDL-cholesterol and late-pubertal status were predictors of the normal liver. At multivariable analysis, however, only Z-BMI, ALT, uric acid, glucose during OGTT and insulin during OGTT were independent predictors of NAFLD. CONCLUSION: Z-BMI, ALT, uric acid, glucose during OGTT and insulin during OGTT are independent predictors of NAFLD in Italian obese children, with most of the prediction explained by ALT and Z-BMI. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17151586/Predictors_of_non_alcoholic_fatty_liver_disease_in_obese_children_ L2 - https://doi.org/10.1038/sj.ejcn.1602588 DB - PRIME DP - Unbound Medicine ER -