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[Anthropometry and female breast cancer: a prospective cohort study in urban Shanghai].

Abstract

OBJECTIVE

To investigate the association between anthropometry and risk of breast cancer among pre-and post-menopausal women in urban Shanghai.

METHODS

A total of 73 461 female residents aged 40 to 70 years in urban Shanghai were recruited in a prospective cohort study (the Shanghai women's health study) during 1997 through 2000, and were actively followed up biennially. During mean follow-up period of 5.66 years, 432 incident cases of breast cancer were identified in the cohort. Cox regression model was used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (CIs).

RESULTS

After adjustment for some potential confounding factors, baseline weight, body mass index(BMI), waist-to-hip ratio(WHR) and weight gain since age 20 were positively associated with the increased risk of breast cancer among postmenopausal women. The positive association between height and breast cancer was found among premenopausal women. Among them, those with height taller than 161 cm at age 20 experienced 1.84 fold increased risk (95% CI: 1.30-2.61) of breast cancer compared to their counterpart with height shorter than 157.1 cm. Women who were either much heavier or lighter than average at age 20 were at reduced risk. Further analyses mutually adjusted for BMI and WHR did not substantially alter the positive association for both BMI and WHR. After further adjustment for BMI, weight gain since age 20 was significantly associated to an increased risk for postmenopausal breast cancer (RR = 1.61, 95% CI: 1.09-2.37).

CONCLUSIONS

Weight gain and central obesity seemed to be strong predictors for the risk of breast cancer among postmenopausal women. Controlling weight and decreasing fat around waist were effective means to prevent postmenopausal breast cancer and height might serve as a risk factor for premenopausal breast cancer.

Authors+Show Affiliations

Cancer Institute of Shanghai Jiaotong Univercity and Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17152508

Citation

Li, Hong-lan, et al. "[Anthropometry and Female Breast Cancer: a Prospective Cohort Study in Urban Shanghai]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 27, no. 6, 2006, pp. 488-93.
Li HL, Gao YT, Li Q, et al. [Anthropometry and female breast cancer: a prospective cohort study in urban Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006;27(6):488-93.
Li, H. L., Gao, Y. T., Li, Q., & Liu, D. K. (2006). [Anthropometry and female breast cancer: a prospective cohort study in urban Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 27(6), pp. 488-93.
Li HL, et al. [Anthropometry and Female Breast Cancer: a Prospective Cohort Study in Urban Shanghai]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006;27(6):488-93. PubMed PMID: 17152508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anthropometry and female breast cancer: a prospective cohort study in urban Shanghai]. AU - Li,Hong-lan, AU - Gao,Yu-tang, AU - Li,Qi, AU - Liu,Da-ke, PY - 2006/12/13/pubmed PY - 2010/4/30/medline PY - 2006/12/13/entrez SP - 488 EP - 93 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 27 IS - 6 N2 - OBJECTIVE: To investigate the association between anthropometry and risk of breast cancer among pre-and post-menopausal women in urban Shanghai. METHODS: A total of 73 461 female residents aged 40 to 70 years in urban Shanghai were recruited in a prospective cohort study (the Shanghai women's health study) during 1997 through 2000, and were actively followed up biennially. During mean follow-up period of 5.66 years, 432 incident cases of breast cancer were identified in the cohort. Cox regression model was used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for some potential confounding factors, baseline weight, body mass index(BMI), waist-to-hip ratio(WHR) and weight gain since age 20 were positively associated with the increased risk of breast cancer among postmenopausal women. The positive association between height and breast cancer was found among premenopausal women. Among them, those with height taller than 161 cm at age 20 experienced 1.84 fold increased risk (95% CI: 1.30-2.61) of breast cancer compared to their counterpart with height shorter than 157.1 cm. Women who were either much heavier or lighter than average at age 20 were at reduced risk. Further analyses mutually adjusted for BMI and WHR did not substantially alter the positive association for both BMI and WHR. After further adjustment for BMI, weight gain since age 20 was significantly associated to an increased risk for postmenopausal breast cancer (RR = 1.61, 95% CI: 1.09-2.37). CONCLUSIONS: Weight gain and central obesity seemed to be strong predictors for the risk of breast cancer among postmenopausal women. Controlling weight and decreasing fat around waist were effective means to prevent postmenopausal breast cancer and height might serve as a risk factor for premenopausal breast cancer. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/17152508/[Anthropometry_and_female_breast_cancer:_a_prospective_cohort_study_in_urban_Shanghai]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2006&vol=27&issue=6&fpage=488 DB - PRIME DP - Unbound Medicine ER -