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Development of an ovarian cancer symptom index: possibilities for earlier detection.
Cancer 2007; 109(2):221-7C

Abstract

BACKGROUND

Currently, screening for ovarian cancer is not recommended for the general population. Targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity.

METHODS

A case-control study of 149 women with ovarian cancer, including 255 women who were in a screening program and 233 women who were referred for pelvic/abdominal ultrasound, was conducted by inviting women to complete a survey of symptoms. Patients were divided randomly into an exploratory group and a confirmatory group. Symptom types, frequency, severity, and duration were compared between cases and controls. Logistic regression analyses were used to determine which factors independently predicted cancer in the exploratory group and then were used to develop a symptom index, which was tested for sensitivity and specificity in the confirmatory group.

RESULTS

Symptoms that were associated significantly with ovarian cancer were pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, and difficulty eating/feeling full when they were present for <1 year and occurred >12 days per month. In a logistic regression analysis, symptoms that were associated independently with cancer were pelvic/abdominal pain (P < .001), increased abdominal size/bloating (P<.001), and difficulty eating/feeling full (P = .010). A symptom index was considered positive if any of those 6 symptoms occurred >12 times per month but were present for <1 year. In the confirmatory sample, the index had a sensitivity of 56.7 for early-stage disease and 79.5% for advanced-stage disease. Specificity was 90% for women age >50 years and 86.7% for women age <50 years.

CONCLUSIONS

Specific symptoms in conjunction with their frequency and duration were useful in identifying women with ovarian cancer. A symptom index may be useful for identifying women who are at risk.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98196-6460, USA. bgoff@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17154394

Citation

Goff, Barbara A., et al. "Development of an Ovarian Cancer Symptom Index: Possibilities for Earlier Detection." Cancer, vol. 109, no. 2, 2007, pp. 221-7.
Goff BA, Mandel LS, Drescher CW, et al. Development of an ovarian cancer symptom index: possibilities for earlier detection. Cancer. 2007;109(2):221-7.
Goff, B. A., Mandel, L. S., Drescher, C. W., Urban, N., Gough, S., Schurman, K. M., ... Andersen, M. R. (2007). Development of an ovarian cancer symptom index: possibilities for earlier detection. Cancer, 109(2), pp. 221-7.
Goff BA, et al. Development of an Ovarian Cancer Symptom Index: Possibilities for Earlier Detection. Cancer. 2007 Jan 15;109(2):221-7. PubMed PMID: 17154394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of an ovarian cancer symptom index: possibilities for earlier detection. AU - Goff,Barbara A, AU - Mandel,Lynn S, AU - Drescher,Charles W, AU - Urban,Nicole, AU - Gough,Shirley, AU - Schurman,Kristi M, AU - Patras,Joshua, AU - Mahony,Barry S, AU - Andersen,M Robyn, PY - 2006/12/13/pubmed PY - 2007/2/27/medline PY - 2006/12/13/entrez SP - 221 EP - 7 JF - Cancer JO - Cancer VL - 109 IS - 2 N2 - BACKGROUND: Currently, screening for ovarian cancer is not recommended for the general population. Targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity. METHODS: A case-control study of 149 women with ovarian cancer, including 255 women who were in a screening program and 233 women who were referred for pelvic/abdominal ultrasound, was conducted by inviting women to complete a survey of symptoms. Patients were divided randomly into an exploratory group and a confirmatory group. Symptom types, frequency, severity, and duration were compared between cases and controls. Logistic regression analyses were used to determine which factors independently predicted cancer in the exploratory group and then were used to develop a symptom index, which was tested for sensitivity and specificity in the confirmatory group. RESULTS: Symptoms that were associated significantly with ovarian cancer were pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, and difficulty eating/feeling full when they were present for <1 year and occurred >12 days per month. In a logistic regression analysis, symptoms that were associated independently with cancer were pelvic/abdominal pain (P < .001), increased abdominal size/bloating (P<.001), and difficulty eating/feeling full (P = .010). A symptom index was considered positive if any of those 6 symptoms occurred >12 times per month but were present for <1 year. In the confirmatory sample, the index had a sensitivity of 56.7 for early-stage disease and 79.5% for advanced-stage disease. Specificity was 90% for women age >50 years and 86.7% for women age <50 years. CONCLUSIONS: Specific symptoms in conjunction with their frequency and duration were useful in identifying women with ovarian cancer. A symptom index may be useful for identifying women who are at risk. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/17154394/Development_of_an_ovarian_cancer_symptom_index:_possibilities_for_earlier_detection_ L2 - https://doi.org/10.1002/cncr.22371 DB - PRIME DP - Unbound Medicine ER -