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Prognostic impact of lymphovascular invasion in radical prostatectomy specimens.
BJU Int. 2007 Mar; 99(3):539-44.BI

Abstract

OBJECTIVE

To estimate the prognostic value of lymphovascular invasion (LVI) in patients with node-negative prostate cancer treated by radical prostatectomy (RP).

PATIENTS AND METHODS

In all, 412 patients with prostatic adenocarcinoma who had RP and pN0 status were analysed for all established standard pathological factors and LVI. The influence of these pathological findings on biochemical failure was evaluated by multivariate analysis with the Cox model. The mean (range) follow-up was 52.5 (10-116) months.

RESULTS

LVI was identified in 42 patients (10.2%) and significantly associated with a high preoperative prostate-specific antigen (PSA) level, a high PSA density, high percentage of positive biopsy cores, high Gleason score, and seminal vesicle invasion. Of the 42 patients with LVI, 33 (79%) had a Gleason score of > or = 7 and 27 (64%) had pathological stage pT3. The 5-year biochemical-free survival was 87.3% for patients with no LVI and 38.3% with LVI on the RP specimen (P < 0.001). By multivariate analysis, LVI and Gleason score were independent predictors of biochemical failure.

CONCLUSION

These results show that in addition to the Gleason score, only LVI is strongly correlated with biochemical failure after RP. These findings support the routine evaluation of LVI status in RP specimens and provide the option for its incorporation into nomograms predictive of oncological outcome.

Authors+Show Affiliations

Department of Urology, Carl-Thiem Hospital Cottbus, University Teaching Hospital, Charité zu Berlin, Thiemstrasse 111, D-03048 Cottbus, Germany. m.may@ctk.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17155973

Citation

May, Matthias, et al. "Prognostic Impact of Lymphovascular Invasion in Radical Prostatectomy Specimens." BJU International, vol. 99, no. 3, 2007, pp. 539-44.
May M, Kaufmann O, Hammermann F, et al. Prognostic impact of lymphovascular invasion in radical prostatectomy specimens. BJU Int. 2007;99(3):539-44.
May, M., Kaufmann, O., Hammermann, F., Loy, V., & Siegsmund, M. (2007). Prognostic impact of lymphovascular invasion in radical prostatectomy specimens. BJU International, 99(3), 539-44.
May M, et al. Prognostic Impact of Lymphovascular Invasion in Radical Prostatectomy Specimens. BJU Int. 2007;99(3):539-44. PubMed PMID: 17155973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic impact of lymphovascular invasion in radical prostatectomy specimens. AU - May,Matthias, AU - Kaufmann,Olaf, AU - Hammermann,Fränze, AU - Loy,Volker, AU - Siegsmund,Michael, Y1 - 2006/11/28/ PY - 2006/12/13/pubmed PY - 2007/5/4/medline PY - 2006/12/13/entrez SP - 539 EP - 44 JF - BJU international JO - BJU Int VL - 99 IS - 3 N2 - OBJECTIVE: To estimate the prognostic value of lymphovascular invasion (LVI) in patients with node-negative prostate cancer treated by radical prostatectomy (RP). PATIENTS AND METHODS: In all, 412 patients with prostatic adenocarcinoma who had RP and pN0 status were analysed for all established standard pathological factors and LVI. The influence of these pathological findings on biochemical failure was evaluated by multivariate analysis with the Cox model. The mean (range) follow-up was 52.5 (10-116) months. RESULTS: LVI was identified in 42 patients (10.2%) and significantly associated with a high preoperative prostate-specific antigen (PSA) level, a high PSA density, high percentage of positive biopsy cores, high Gleason score, and seminal vesicle invasion. Of the 42 patients with LVI, 33 (79%) had a Gleason score of > or = 7 and 27 (64%) had pathological stage pT3. The 5-year biochemical-free survival was 87.3% for patients with no LVI and 38.3% with LVI on the RP specimen (P < 0.001). By multivariate analysis, LVI and Gleason score were independent predictors of biochemical failure. CONCLUSION: These results show that in addition to the Gleason score, only LVI is strongly correlated with biochemical failure after RP. These findings support the routine evaluation of LVI status in RP specimens and provide the option for its incorporation into nomograms predictive of oncological outcome. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/17155973/Prognostic_impact_of_lymphovascular_invasion_in_radical_prostatectomy_specimens_ L2 - https://doi.org/10.1111/j.1464-410X.2006.06650.x DB - PRIME DP - Unbound Medicine ER -