Tags

Type your tag names separated by a space and hit enter

Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis.
Thromb Res. 2007; 120(3):371-9.TR

Abstract

INTRODUCTION

We have recently reported that different hormone regimens given to healthy post-menopausal women had markedly different effects on activation of coagulation. Low-dose hormone therapy (HT) and raloxifene, as opposed to conventional-dose HT and tibolone, were associated with no or minor activation of coagulation. The aim of this study was to elucidate the mechanism(s) for differences in coagulation activation by analysing clotting and fibrinolytic factors and coagulation inhibitors.

MATERIALS AND METHODS

202 healthy women were randomly assigned to receive treatment for 12 weeks with either low dose HT containing 1 mg 17 beta-estradiol+0.5 mg norethisterone acetate (NETA) (n=50), conventional dose HT containing 2 mg 17 beta-estradiol and 1 mg NETA (n=50), 2.5 mg tibolone (n=51), or 60 mg raloxifene (n=51) in an open-label design.

RESULTS

The conventional-and low-dose HT groups generally showed similar effects, i.e., reductions in both clotting factors and inhibitors, but the effects were markedly more pronounced in the conventional-dose HT group. Compared with the low-dose HT group those treated with tibolone showed more pronounced decreases in factor VII, less reduction of antithrombin and protein C and even increased levels in protein S and tissue factor pathway inhibitor. As opposed to the low-dose HT group the reductions in inhibitors in the raloxifene group were smaller. Moreover in those allocated to raloxifene reduced levels of fibrinogen were seen.

CONCLUSIONS

Our study demonstrates that the different HT regimens and raloxifene exert differential effects on coagulation factors, inhibitors and fibrinolytic factors.

Authors+Show Affiliations

Department of Hematology, Ullevål University Hospital Trust, Oslo, Norway. a.l.eilertsen@medisin.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17156824

Citation

Eilertsen, Anette Løken, et al. "Differential Effects of Conventional and Low Dose Oral Hormone Therapy (HT), Tibolone, and Raloxifene On Coagulation and Fibrinolysis." Thrombosis Research, vol. 120, no. 3, 2007, pp. 371-9.
Eilertsen AL, Sandvik L, Mowinckel MC, et al. Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis. Thromb Res. 2007;120(3):371-9.
Eilertsen, A. L., Sandvik, L., Mowinckel, M. C., Andersen, T. O., Qvigstad, E., & Sandset, P. M. (2007). Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis. Thrombosis Research, 120(3), 371-9.
Eilertsen AL, et al. Differential Effects of Conventional and Low Dose Oral Hormone Therapy (HT), Tibolone, and Raloxifene On Coagulation and Fibrinolysis. Thromb Res. 2007;120(3):371-9. PubMed PMID: 17156824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis. AU - Eilertsen,Anette Løken, AU - Sandvik,Leiv, AU - Mowinckel,Marie Christine, AU - Andersen,Trine Opstad, AU - Qvigstad,Erik, AU - Sandset,Per Morten, Y1 - 2006/12/15/ PY - 2006/06/14/received PY - 2006/10/12/revised PY - 2006/10/23/accepted PY - 2006/12/13/pubmed PY - 2007/9/20/medline PY - 2006/12/13/entrez SP - 371 EP - 9 JF - Thrombosis research JO - Thromb. Res. VL - 120 IS - 3 N2 - INTRODUCTION: We have recently reported that different hormone regimens given to healthy post-menopausal women had markedly different effects on activation of coagulation. Low-dose hormone therapy (HT) and raloxifene, as opposed to conventional-dose HT and tibolone, were associated with no or minor activation of coagulation. The aim of this study was to elucidate the mechanism(s) for differences in coagulation activation by analysing clotting and fibrinolytic factors and coagulation inhibitors. MATERIALS AND METHODS: 202 healthy women were randomly assigned to receive treatment for 12 weeks with either low dose HT containing 1 mg 17 beta-estradiol+0.5 mg norethisterone acetate (NETA) (n=50), conventional dose HT containing 2 mg 17 beta-estradiol and 1 mg NETA (n=50), 2.5 mg tibolone (n=51), or 60 mg raloxifene (n=51) in an open-label design. RESULTS: The conventional-and low-dose HT groups generally showed similar effects, i.e., reductions in both clotting factors and inhibitors, but the effects were markedly more pronounced in the conventional-dose HT group. Compared with the low-dose HT group those treated with tibolone showed more pronounced decreases in factor VII, less reduction of antithrombin and protein C and even increased levels in protein S and tissue factor pathway inhibitor. As opposed to the low-dose HT group the reductions in inhibitors in the raloxifene group were smaller. Moreover in those allocated to raloxifene reduced levels of fibrinogen were seen. CONCLUSIONS: Our study demonstrates that the different HT regimens and raloxifene exert differential effects on coagulation factors, inhibitors and fibrinolytic factors. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/17156824/Differential_effects_of_conventional_and_low_dose_oral_hormone_therapy__HT__tibolone_and_raloxifene_on_coagulation_and_fibrinolysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(06)00426-9 DB - PRIME DP - Unbound Medicine ER -