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Coffee consumption and risk of coronary heart disease: a meta-analysis.
Nutr Metab Cardiovasc Dis. 2007 Mar; 17(3):209-23.NM

Abstract

BACKGROUND AND AIMS

During the past three decades the relationship between habitual coffee drinking and coronary heart disease (CHD) has been assessed in numerous studies, with conflicting results. The aim of this study was to systematically examine the data published on the association between habitual coffee consumption and risk of CHD.

METHODS AND RESULTS

Thirteen case-control and 10 cohort studies were included. Case-control studies incorporated 9487 cases of CHD and 27,747 controls, and cohort studies included a total of 403,631 participants that were followed for between 3 and 44 years. The summary of odds ratios (OR) for the case-control studies showed statistically significant associations between coffee consumption and CHD for the highest intake group (>4 cups/day), OR 1.83 (95% CI 1.49-2.24; P<0.0001), and for the second highest category (3-4 cups/day), OR 1.33 (95% CI 1.04-1.71; P<0.0001), while no significant association emerged for low daily coffee intake (< or =2 cups/day), OR 1.03 (95% CI 0.87-1.21; P=0.45). The analysis of long-term follow-up cohort studies did not show any association between the consumption of coffee and CHD, with a relative risk (RR) of 1.16 (95% CI 0.95-1.41; P=0.14) for the highest category, and 1.05 (95% CI 0.90-1.22; P=0.57) and 1.04 (95% CI 0.90-1.19; P=0.60) for the second and third highest categories, respectively. These results did not differ substantially when controlling for region of origin, fatal and non-fatal events, year of publication, and number of years of follow-up.

CONCLUSIONS

Despite a significant association between high consumption of coffee and CHD reported among case-control studies, no significant association between daily coffee consumption and CHD emerged from long-term follow-up prospective cohort studies.

Authors+Show Affiliations

Department of Medical and Surgical Critical Care and Center for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy. francescosofi@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17156982

Citation

Sofi, Francesco, et al. "Coffee Consumption and Risk of Coronary Heart Disease: a Meta-analysis." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 17, no. 3, 2007, pp. 209-23.
Sofi F, Conti AA, Gori AM, et al. Coffee consumption and risk of coronary heart disease: a meta-analysis. Nutr Metab Cardiovasc Dis. 2007;17(3):209-23.
Sofi, F., Conti, A. A., Gori, A. M., Eliana Luisi, M. L., Casini, A., Abbate, R., & Gensini, G. F. (2007). Coffee consumption and risk of coronary heart disease: a meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 17(3), 209-23.
Sofi F, et al. Coffee Consumption and Risk of Coronary Heart Disease: a Meta-analysis. Nutr Metab Cardiovasc Dis. 2007;17(3):209-23. PubMed PMID: 17156982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and risk of coronary heart disease: a meta-analysis. AU - Sofi,Francesco, AU - Conti,Andrea A, AU - Gori,Anna Maria, AU - Eliana Luisi,Maria Luisa, AU - Casini,Alessandro, AU - Abbate,Rosanna, AU - Gensini,Gian Franco, Y1 - 2006/12/05/ PY - 2006/05/27/received PY - 2006/07/14/revised PY - 2006/07/22/accepted PY - 2006/12/13/pubmed PY - 2007/4/12/medline PY - 2006/12/13/entrez SP - 209 EP - 23 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 17 IS - 3 N2 - BACKGROUND AND AIMS: During the past three decades the relationship between habitual coffee drinking and coronary heart disease (CHD) has been assessed in numerous studies, with conflicting results. The aim of this study was to systematically examine the data published on the association between habitual coffee consumption and risk of CHD. METHODS AND RESULTS: Thirteen case-control and 10 cohort studies were included. Case-control studies incorporated 9487 cases of CHD and 27,747 controls, and cohort studies included a total of 403,631 participants that were followed for between 3 and 44 years. The summary of odds ratios (OR) for the case-control studies showed statistically significant associations between coffee consumption and CHD for the highest intake group (>4 cups/day), OR 1.83 (95% CI 1.49-2.24; P<0.0001), and for the second highest category (3-4 cups/day), OR 1.33 (95% CI 1.04-1.71; P<0.0001), while no significant association emerged for low daily coffee intake (< or =2 cups/day), OR 1.03 (95% CI 0.87-1.21; P=0.45). The analysis of long-term follow-up cohort studies did not show any association between the consumption of coffee and CHD, with a relative risk (RR) of 1.16 (95% CI 0.95-1.41; P=0.14) for the highest category, and 1.05 (95% CI 0.90-1.22; P=0.57) and 1.04 (95% CI 0.90-1.19; P=0.60) for the second and third highest categories, respectively. These results did not differ substantially when controlling for region of origin, fatal and non-fatal events, year of publication, and number of years of follow-up. CONCLUSIONS: Despite a significant association between high consumption of coffee and CHD reported among case-control studies, no significant association between daily coffee consumption and CHD emerged from long-term follow-up prospective cohort studies. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17156982/Coffee_consumption_and_risk_of_coronary_heart_disease:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(06)00169-4 DB - PRIME DP - Unbound Medicine ER -