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Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system.
Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan; 144(4):342-7.CB

Abstract

We determined the effects of immobilization stress on antioxidant status, protein oxidation and lipid peroxidation in brain, liver, kidney, heart and stomach of rats. Sixteen male Wistar rats (3 months old) were divided into controls (C) and immobilization stress group (IS). IS rats were immobilized for 180 min/day for 15 days. Plasma corticosterone levels were increased in IS group. Copper,zinc-superoxide dismutase activities were increased in brain, liver and kidney, but decreased in the heart and stomach after immobilization. Catalase activities were increased in brain, kidney and heart, and decreased in liver and stomach. Selenium-dependent glutathione peroxidase activities were decreased in brain and kidney, but increased in heart and stomach. Reduced glutathione levels were decreased, while protein carbonyl, conjugated dienes and thiobarbituric acid-reactive substances levels were increased in all tissues. Our results showed that the response of antioxidant defense system to stress differs for each tissue, and protein oxidation and lipid peroxidation is induced by immobilization stress in peripheral tissues.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17157074

Citation

Sahin, Emel, and Saadet Gümüşlü. "Immobilization Stress in Rat Tissues: Alterations in Protein Oxidation, Lipid Peroxidation and Antioxidant Defense System." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 144, no. 4, 2007, pp. 342-7.
Sahin E, Gümüşlü S. Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. Comp Biochem Physiol C Toxicol Pharmacol. 2007;144(4):342-7.
Sahin, E., & Gümüşlü, S. (2007). Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 144(4), 342-7.
Sahin E, Gümüşlü S. Immobilization Stress in Rat Tissues: Alterations in Protein Oxidation, Lipid Peroxidation and Antioxidant Defense System. Comp Biochem Physiol C Toxicol Pharmacol. 2007;144(4):342-7. PubMed PMID: 17157074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. AU - Sahin,Emel, AU - Gümüşlü,Saadet, Y1 - 2006/10/27/ PY - 2006/02/06/received PY - 2006/07/07/revised PY - 2006/10/21/accepted PY - 2006/12/13/pubmed PY - 2007/5/26/medline PY - 2006/12/13/entrez SP - 342 EP - 7 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 144 IS - 4 N2 - We determined the effects of immobilization stress on antioxidant status, protein oxidation and lipid peroxidation in brain, liver, kidney, heart and stomach of rats. Sixteen male Wistar rats (3 months old) were divided into controls (C) and immobilization stress group (IS). IS rats were immobilized for 180 min/day for 15 days. Plasma corticosterone levels were increased in IS group. Copper,zinc-superoxide dismutase activities were increased in brain, liver and kidney, but decreased in the heart and stomach after immobilization. Catalase activities were increased in brain, kidney and heart, and decreased in liver and stomach. Selenium-dependent glutathione peroxidase activities were decreased in brain and kidney, but increased in heart and stomach. Reduced glutathione levels were decreased, while protein carbonyl, conjugated dienes and thiobarbituric acid-reactive substances levels were increased in all tissues. Our results showed that the response of antioxidant defense system to stress differs for each tissue, and protein oxidation and lipid peroxidation is induced by immobilization stress in peripheral tissues. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/17157074/Immobilization_stress_in_rat_tissues:_alterations_in_protein_oxidation_lipid_peroxidation_and_antioxidant_defense_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(06)00229-8 DB - PRIME DP - Unbound Medicine ER -