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Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study.
Clin Ther 2006; 28(10):1726-35; discussion 1710-1CT

Abstract

BACKGROUND

Abdominal pain/discomfort, bloating, and constipation are gastrointestinal dysmotility and sensory symptoms associated with irritable bowel syndrome (IBS). No studies have followed patients with IBS symptoms for 1 year under conditions of routine clinical practice to assess prospectively the impact of treatments on health outcomes.

OBJECTIVE

The objective of this ongoing, naturalistic study is to assess the long-term impact of IBS treatments on quality of life (QOL), work productivity, and resource utilization. This report describes the baseline characteristics and patterns of care of the patients enrolled in this study.

METHODS

Patients with physician-diagnosed IBS symptoms were enrolled from 147 physician sites across Canada between May 4, 2004, and March 31, 2005. Clinical data were collected at baseline and at the end of the 12-month follow-up (patients were followed for 1 year between May 4, 2005, and March 31, 2006). Patient-reported outcomes were collected at baseline and at months 1, 2, 6, 9, and 12. Health-related QOL, health status, and work productivity were assessed with the IBS-QOL, a 5-item EuroQol descriptive system, and Work Productivity and Activity Impairment questionnaires, respectively. A resource utilization questionnaire elicited information on physician; visits, treatments, and procedures. Baseline data are reported here.

RESULTS

Data were obtained from 1555 patients; 85.1% (1320/1552) were women. Patients had a mean (SD) age of 45.8 (15.0) years and mean (SD) duration of IBS symptoms of 11.4 (11.5) years. Self-reported bowel patterns were predominantly constipation (41.0%, 587/1433) and constipation alternating with diarrhea (39.4%, 564/1433); 60.3% (938/1555) of subjects used > or =3 IBS treatments in the previous 4 weeks. Approximately 50% of all patients reported distress "quite a bit or "extremely" for abdominal pain, gas, bloating, and constipation. The mean overall IBS-QOL score (0-100 scale, with 0 indicating poor QOL) was 66.3; food avoidance (51.8) and health worry (59.3) were the most serious concerns. Patients reported 5.6% work absenteeism, 31.4% presenteeism, and 34.6% overall work productivity loss, equivalent to 13.8 hours lost productivity per 40-hour workweek.

CONCLUSIONS

The baseline data from this ongoing, prospective, naturalistic study are consistent with previous findings that suggested significant use of health care resources with concomitant low QOL and decreased work productivity in patients with IBS symptoms.

Authors+Show Affiliations

Centre Hospitalier Afflié Universitaire de Québec Hôpital St-Sacrement, Quebec City, Quebec, Canada. pierre.pare@cha.quebec.qc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17157129

Citation

Paré, Pierre, et al. "Health-related Quality of Life, Work Productivity, and Health Care Resource Utilization of Subjects With Irritable Bowel Syndrome: Baseline Results From LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a Naturalistic Study." Clinical Therapeutics, vol. 28, no. 10, 2006, pp. 1726-35; discussion 1710-1.
Paré P, Gray J, Lam S, et al. Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clin Ther. 2006;28(10):1726-35; discussion 1710-1.
Paré, P., Gray, J., Lam, S., Balshaw, R., Khorasheh, S., Barbeau, M., ... McBurney, C. R. (2006). Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clinical Therapeutics, 28(10), pp. 1726-35; discussion 1710-1.
Paré P, et al. Health-related Quality of Life, Work Productivity, and Health Care Resource Utilization of Subjects With Irritable Bowel Syndrome: Baseline Results From LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a Naturalistic Study. Clin Ther. 2006;28(10):1726-35; discussion 1710-1. PubMed PMID: 17157129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. AU - Paré,Pierre, AU - Gray,James, AU - Lam,Sy, AU - Balshaw,Robert, AU - Khorasheh,Shideh, AU - Barbeau,Martin, AU - Kelly,Suzanne, AU - McBurney,Christopher R, PY - 2006/08/20/accepted PY - 2006/12/13/pubmed PY - 2007/2/14/medline PY - 2006/12/13/entrez SP - 1726-35; discussion 1710-1 JF - Clinical therapeutics JO - Clin Ther VL - 28 IS - 10 N2 - BACKGROUND: Abdominal pain/discomfort, bloating, and constipation are gastrointestinal dysmotility and sensory symptoms associated with irritable bowel syndrome (IBS). No studies have followed patients with IBS symptoms for 1 year under conditions of routine clinical practice to assess prospectively the impact of treatments on health outcomes. OBJECTIVE: The objective of this ongoing, naturalistic study is to assess the long-term impact of IBS treatments on quality of life (QOL), work productivity, and resource utilization. This report describes the baseline characteristics and patterns of care of the patients enrolled in this study. METHODS: Patients with physician-diagnosed IBS symptoms were enrolled from 147 physician sites across Canada between May 4, 2004, and March 31, 2005. Clinical data were collected at baseline and at the end of the 12-month follow-up (patients were followed for 1 year between May 4, 2005, and March 31, 2006). Patient-reported outcomes were collected at baseline and at months 1, 2, 6, 9, and 12. Health-related QOL, health status, and work productivity were assessed with the IBS-QOL, a 5-item EuroQol descriptive system, and Work Productivity and Activity Impairment questionnaires, respectively. A resource utilization questionnaire elicited information on physician; visits, treatments, and procedures. Baseline data are reported here. RESULTS: Data were obtained from 1555 patients; 85.1% (1320/1552) were women. Patients had a mean (SD) age of 45.8 (15.0) years and mean (SD) duration of IBS symptoms of 11.4 (11.5) years. Self-reported bowel patterns were predominantly constipation (41.0%, 587/1433) and constipation alternating with diarrhea (39.4%, 564/1433); 60.3% (938/1555) of subjects used > or =3 IBS treatments in the previous 4 weeks. Approximately 50% of all patients reported distress "quite a bit or "extremely" for abdominal pain, gas, bloating, and constipation. The mean overall IBS-QOL score (0-100 scale, with 0 indicating poor QOL) was 66.3; food avoidance (51.8) and health worry (59.3) were the most serious concerns. Patients reported 5.6% work absenteeism, 31.4% presenteeism, and 34.6% overall work productivity loss, equivalent to 13.8 hours lost productivity per 40-hour workweek. CONCLUSIONS: The baseline data from this ongoing, prospective, naturalistic study are consistent with previous findings that suggested significant use of health care resources with concomitant low QOL and decreased work productivity in patients with IBS symptoms. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/17157129/Health_related_quality_of_life_work_productivity_and_health_care_resource_utilization_of_subjects_with_irritable_bowel_syndrome:_baseline_results_from_LOGIC__Longitudinal_Outcomes_Study_of_Gastrointestinal_Symptoms_in_Canada__a_naturalistic_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-2918(06)00250-5 DB - PRIME DP - Unbound Medicine ER -