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Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study.
Am J Clin Nutr 2006; 84(6):1406-11AJ

Abstract

BACKGROUND

An elevated blood concentration of homocysteine is an established risk factor for cognitive impairment and dementia, but associations between cognition and methylmalonic acid (MMA), a related metabolic marker of vitamin B-12 deficiency, are less clear.

OBJECTIVE

The aim was to determine the utility of serum MMA and holotranscobalamin as markers of vitamin B-12 status in relation to cognitive function and to investigate their association with discrete cognitive domains.

DESIGN

This was a cross-sectional survey of 84 nondemented elderly participants (aged >69 y) from the Welsh cohort of the Medical Research Council's Cognitive Function and Ageing Study. Cognitive status was determined by Mini-Mental State Examination (MMSE) and the Cognitive Section of the Cambridge Mental Disorders of the Elderly Examination (CAMCOG).

RESULTS

Nearly one-half (43%) of the persons selected had likely metabolically significant vitamin B-12 deficiency. Higher MMA concentrations were associated with lower MMSE scores independent of age and education (P = 0.007). MMA concentration correlated inversely with CAMCOG scores of ideational praxis (P < 0.05) and language comprehension (P < 0.05) and expression (P < 0.01). Serum folate correlated weakly but significantly with language (P < 0.05), remote memory (P < 0.05), and constructional and ideational praxis scores (P < 0.05 and P < 0.01, respectively).

CONCLUSION

The high prevalence of likely metabolically significant vitamin B-12 deficiency in the elderly is associated with lower cognitive function scores and particularly with lower scores of language comprehension and expression.

Authors+Show Affiliations

University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17158424

Citation

McCracken, Cherie, et al. "Methylmalonic Acid and Cognitive Function in the Medical Research Council Cognitive Function and Ageing Study." The American Journal of Clinical Nutrition, vol. 84, no. 6, 2006, pp. 1406-11.
McCracken C, Hudson P, Ellis R, et al. Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. Am J Clin Nutr. 2006;84(6):1406-11.
McCracken, C., Hudson, P., Ellis, R., & McCaddon, A. (2006). Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. The American Journal of Clinical Nutrition, 84(6), pp. 1406-11.
McCracken C, et al. Methylmalonic Acid and Cognitive Function in the Medical Research Council Cognitive Function and Ageing Study. Am J Clin Nutr. 2006;84(6):1406-11. PubMed PMID: 17158424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. AU - McCracken,Cherie, AU - Hudson,Peter, AU - Ellis,Richard, AU - McCaddon,Andrew, AU - ,, PY - 2006/12/13/pubmed PY - 2007/1/11/medline PY - 2006/12/13/entrez SP - 1406 EP - 11 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 84 IS - 6 N2 - BACKGROUND: An elevated blood concentration of homocysteine is an established risk factor for cognitive impairment and dementia, but associations between cognition and methylmalonic acid (MMA), a related metabolic marker of vitamin B-12 deficiency, are less clear. OBJECTIVE: The aim was to determine the utility of serum MMA and holotranscobalamin as markers of vitamin B-12 status in relation to cognitive function and to investigate their association with discrete cognitive domains. DESIGN: This was a cross-sectional survey of 84 nondemented elderly participants (aged >69 y) from the Welsh cohort of the Medical Research Council's Cognitive Function and Ageing Study. Cognitive status was determined by Mini-Mental State Examination (MMSE) and the Cognitive Section of the Cambridge Mental Disorders of the Elderly Examination (CAMCOG). RESULTS: Nearly one-half (43%) of the persons selected had likely metabolically significant vitamin B-12 deficiency. Higher MMA concentrations were associated with lower MMSE scores independent of age and education (P = 0.007). MMA concentration correlated inversely with CAMCOG scores of ideational praxis (P < 0.05) and language comprehension (P < 0.05) and expression (P < 0.01). Serum folate correlated weakly but significantly with language (P < 0.05), remote memory (P < 0.05), and constructional and ideational praxis scores (P < 0.05 and P < 0.01, respectively). CONCLUSION: The high prevalence of likely metabolically significant vitamin B-12 deficiency in the elderly is associated with lower cognitive function scores and particularly with lower scores of language comprehension and expression. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17158424/Methylmalonic_acid_and_cognitive_function_in_the_Medical_Research_Council_Cognitive_Function_and_Ageing_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/84.6.1406 DB - PRIME DP - Unbound Medicine ER -