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Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly.
Am J Clin Nutr. 2006 Dec; 84(6):1473-80.AJ

Abstract

BACKGROUND

Apolipoprotein E (APOE) plays a central role in VLDL metabolism. Both APOE e4 allele (APOE4) and C-reactive protein (CRP) are associated with greater risk of dementia and vascular disease, but APOE4 carriers have lower blood concentrations of CRP than do noncarriers, possibly through a mechanism favoring the clearance of the CRP VLDL-bound fraction. Homocysteine, another risk factor for vascular disease and dementia, also binds to VLDL in blood. However, the association between APOE4 and hyperhomocysteinemia has never been thoroughly investigated.

OBJECTIVE

We investigated in an elderly population whether 1) APOE4 is associated with hyperhomocysteinemia [plasma total homocysteine (tHcy) > 15 micromol/L], 2) hyperhomocysteinemia affects the association between APOE4 and high CRP (serum CRP > 3 mg/L), and 3) B vitamin status affects these associations.

DESIGN

APOE4 genotypes were assessed and tHcy, CRP, and serum concentrations of folate and vitamin B-12 were measured in 671 cognitively healthy subjects (52% women; mean age: 73 y) from an Italian population-based prospective cohort study.

RESULTS

APOE4 carriers without high CRP [multivariate-adjusted odds ratio (OR): 0.22; 95% CI: 0.08, 0.59] had a lower risk of hyperhomocysteinemia than did noncarriers. The risk of high CRP was lower in APOE4 carriers without hyperhomocysteinemia (multivariate-adjusted OR: 0.51; 95% CI: 0.31, 0.85) than in noncarriers. The associations were not affected by B vitamin status.

CONCLUSION

Independently from B vitamin status, APOE4 carriers have a lower risk of hyperhomocysteinemia and of high CRP than do noncarriers, but the presence of one condition attenuates the association of APOE4 with the other condition.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola-Malpighi, Bologna, Italy. ravaglia@med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17158432

Citation

Ravaglia, Giovanni, et al. "Apolipoprotein E E4 Allele Affects Risk of Hyperhomocysteinemia in the Elderly." The American Journal of Clinical Nutrition, vol. 84, no. 6, 2006, pp. 1473-80.
Ravaglia G, Forti P, Maioli F, et al. Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. Am J Clin Nutr. 2006;84(6):1473-80.
Ravaglia, G., Forti, P., Maioli, F., Chiappelli, M., Montesi, F., Bianchin, M., Licastro, F., & Patterson, C. (2006). Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. The American Journal of Clinical Nutrition, 84(6), 1473-80.
Ravaglia G, et al. Apolipoprotein E E4 Allele Affects Risk of Hyperhomocysteinemia in the Elderly. Am J Clin Nutr. 2006;84(6):1473-80. PubMed PMID: 17158432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. AU - Ravaglia,Giovanni, AU - Forti,Paola, AU - Maioli,Fabiola, AU - Chiappelli,Martina, AU - Montesi,Fausta, AU - Bianchin,Marisa, AU - Licastro,Federico, AU - Patterson,Christopher, PY - 2006/12/13/pubmed PY - 2007/1/11/medline PY - 2006/12/13/entrez SP - 1473 EP - 80 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 84 IS - 6 N2 - BACKGROUND: Apolipoprotein E (APOE) plays a central role in VLDL metabolism. Both APOE e4 allele (APOE4) and C-reactive protein (CRP) are associated with greater risk of dementia and vascular disease, but APOE4 carriers have lower blood concentrations of CRP than do noncarriers, possibly through a mechanism favoring the clearance of the CRP VLDL-bound fraction. Homocysteine, another risk factor for vascular disease and dementia, also binds to VLDL in blood. However, the association between APOE4 and hyperhomocysteinemia has never been thoroughly investigated. OBJECTIVE: We investigated in an elderly population whether 1) APOE4 is associated with hyperhomocysteinemia [plasma total homocysteine (tHcy) > 15 micromol/L], 2) hyperhomocysteinemia affects the association between APOE4 and high CRP (serum CRP > 3 mg/L), and 3) B vitamin status affects these associations. DESIGN: APOE4 genotypes were assessed and tHcy, CRP, and serum concentrations of folate and vitamin B-12 were measured in 671 cognitively healthy subjects (52% women; mean age: 73 y) from an Italian population-based prospective cohort study. RESULTS: APOE4 carriers without high CRP [multivariate-adjusted odds ratio (OR): 0.22; 95% CI: 0.08, 0.59] had a lower risk of hyperhomocysteinemia than did noncarriers. The risk of high CRP was lower in APOE4 carriers without hyperhomocysteinemia (multivariate-adjusted OR: 0.51; 95% CI: 0.31, 0.85) than in noncarriers. The associations were not affected by B vitamin status. CONCLUSION: Independently from B vitamin status, APOE4 carriers have a lower risk of hyperhomocysteinemia and of high CRP than do noncarriers, but the presence of one condition attenuates the association of APOE4 with the other condition. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17158432/Apolipoprotein_E_e4_allele_affects_risk_of_hyperhomocysteinemia_in_the_elderly_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/84.6.1473 DB - PRIME DP - Unbound Medicine ER -