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Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.
Am J Clin Nutr 2006; 84(6):1506-12AJ

Abstract

BACKGROUND

The relations of elevated homocysteine, low folate, and vitamin B-12 with cognitive performance in nondemented elderly are not well established. Limited research data suggest differential effects of homocysteine and folate on specific cognitive domains.

OBJECTIVE

The aim was to examine the independent associations of homocysteine, folate, and vitamin B-12 with cognitive performance in high-functioning elderly Chinese.

DESIGN

Homocysteine, folate, and vitamin B-12 concentrations were measured in fasting blood samples of 451 Chinese aged >or=55 y with Mini-Mental State Examination scores >or=24 and who were considered fully independent based on Activities of Daily Living score. Cognitive functions were assessed by a neuropsychological test battery. Independent associations (standardized beta) were determined in multiple linear regression models that simultaneously controlled for potential confounders.

RESULTS

Log-transformed homocysteine was inversely associated with performance on Block Design (beta = -0.319, P = 0.006) and the written Symbol Digit Modality Test (beta = -0.129, P = 0.031). Log-transformed folate was significantly associated with Rey Auditory Verbal Learning Test delayed recall (beta = 0.139, P = 0.010), verbal learning (beta = 0.112, P = 0.038), percentage of forgetting (beta = -0.139, P = 0.013), and the Categorical Verbal Fluency test (beta = 0.104, P = 0.042). Vitamin B-12 was not significantly associated with any cognitive test score.

CONCLUSIONS

In this high-functioning elderly Chinese population, elevated homocysteine is associated with deficits in constructional ability and processing speed and folate is associated with measures of episodic memory and language. Our results provide support for differential effects of homocysteine and folate on specific cognitive functions.

Authors+Show Affiliations

Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17158436

Citation

Feng, Lei, et al. "Homocysteine, Folate, and Vitamin B-12 and Cognitive Performance in Older Chinese Adults: Findings From the Singapore Longitudinal Ageing Study." The American Journal of Clinical Nutrition, vol. 84, no. 6, 2006, pp. 1506-12.
Feng L, Ng TP, Chuah L, et al. Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study. Am J Clin Nutr. 2006;84(6):1506-12.
Feng, L., Ng, T. P., Chuah, L., Niti, M., & Kua, E. H. (2006). Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study. The American Journal of Clinical Nutrition, 84(6), pp. 1506-12.
Feng L, et al. Homocysteine, Folate, and Vitamin B-12 and Cognitive Performance in Older Chinese Adults: Findings From the Singapore Longitudinal Ageing Study. Am J Clin Nutr. 2006;84(6):1506-12. PubMed PMID: 17158436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study. AU - Feng,Lei, AU - Ng,Tze-Pin, AU - Chuah,Lisa, AU - Niti,Mathew, AU - Kua,Ee-Heok, PY - 2006/12/13/pubmed PY - 2007/1/11/medline PY - 2006/12/13/entrez SP - 1506 EP - 12 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 84 IS - 6 N2 - BACKGROUND: The relations of elevated homocysteine, low folate, and vitamin B-12 with cognitive performance in nondemented elderly are not well established. Limited research data suggest differential effects of homocysteine and folate on specific cognitive domains. OBJECTIVE: The aim was to examine the independent associations of homocysteine, folate, and vitamin B-12 with cognitive performance in high-functioning elderly Chinese. DESIGN: Homocysteine, folate, and vitamin B-12 concentrations were measured in fasting blood samples of 451 Chinese aged >or=55 y with Mini-Mental State Examination scores >or=24 and who were considered fully independent based on Activities of Daily Living score. Cognitive functions were assessed by a neuropsychological test battery. Independent associations (standardized beta) were determined in multiple linear regression models that simultaneously controlled for potential confounders. RESULTS: Log-transformed homocysteine was inversely associated with performance on Block Design (beta = -0.319, P = 0.006) and the written Symbol Digit Modality Test (beta = -0.129, P = 0.031). Log-transformed folate was significantly associated with Rey Auditory Verbal Learning Test delayed recall (beta = 0.139, P = 0.010), verbal learning (beta = 0.112, P = 0.038), percentage of forgetting (beta = -0.139, P = 0.013), and the Categorical Verbal Fluency test (beta = 0.104, P = 0.042). Vitamin B-12 was not significantly associated with any cognitive test score. CONCLUSIONS: In this high-functioning elderly Chinese population, elevated homocysteine is associated with deficits in constructional ability and processing speed and folate is associated with measures of episodic memory and language. Our results provide support for differential effects of homocysteine and folate on specific cognitive functions. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17158436/Homocysteine_folate_and_vitamin_B_12_and_cognitive_performance_in_older_Chinese_adults:_findings_from_the_Singapore_Longitudinal_Ageing_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/84.6.1506 DB - PRIME DP - Unbound Medicine ER -