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Height loss in older men: associations with total mortality and incidence of cardiovascular disease.
Arch Intern Med. 2006 Dec 11-25; 166(22):2546-52.AI

Abstract

BACKGROUND

Height declines with age, but the impact of height loss on health outcomes has been little studied. We examined the relationships between height loss over 20 years (starting at middle age) and subsequent total mortality and incidence of coronary heart disease and stroke in older men.

METHODS

A prospective study was performed on 4213 men whose height was measured between the ages of 40 and 59 years and again 20 years later between the ages of 60 and 79 years. The men were then followed up for a mean period of 6 years, during which 760 deaths occurred.

RESULTS

Height loss correlated significantly with initial age (r = 0.20) and weight loss (r = 0.20). Total mortality risk was higher in men with a height loss of 3 cm or more than in men with a height loss of less than 1 cm (age-adjusted relative risk [RR], 1.64; 95% confidence interval [CI], 1.33-2.03). The excess deaths were largely attributable to cardiovascular and respiratory conditions and other causes but not to cancer. Adjustment for age, established cardiovascular risk factors, lung function, preexisting cardiovascular disease, albumin concentration, self-reported poor or fair health, and weight loss had a modest impact on the increased risk of total mortality (RR, 1.45; 95% CI, 1.15-1.82). The risk of major coronary heart disease events was increased only in men with a height loss of 3 cm or more even after adjustment (adjusted RR, 1.42; 95% CI, 1.02-1.98; > or =3.0 cm vs <3.0 cm); no association was seen with stroke risk.

CONCLUSION

Marked height loss (> or =3 cm) in older men is independently associated with an increased risk of all-cause mortality and coronary heart disease.

Authors+Show Affiliations

Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, England. goya@pcps.ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17159023

Citation

Wannamethee, S Goya, et al. "Height Loss in Older Men: Associations With Total Mortality and Incidence of Cardiovascular Disease." Archives of Internal Medicine, vol. 166, no. 22, 2006, pp. 2546-52.
Wannamethee SG, Shaper AG, Lennon L, et al. Height loss in older men: associations with total mortality and incidence of cardiovascular disease. Arch Intern Med. 2006;166(22):2546-52.
Wannamethee, S. G., Shaper, A. G., Lennon, L., & Whincup, P. H. (2006). Height loss in older men: associations with total mortality and incidence of cardiovascular disease. Archives of Internal Medicine, 166(22), 2546-52.
Wannamethee SG, et al. Height Loss in Older Men: Associations With Total Mortality and Incidence of Cardiovascular Disease. Arch Intern Med. 2006;166(22):2546-52. PubMed PMID: 17159023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Height loss in older men: associations with total mortality and incidence of cardiovascular disease. AU - Wannamethee,S Goya, AU - Shaper,A Gerald, AU - Lennon,Lucy, AU - Whincup,Peter H, PY - 2006/12/13/pubmed PY - 2007/1/17/medline PY - 2006/12/13/entrez SP - 2546 EP - 52 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 22 N2 - BACKGROUND: Height declines with age, but the impact of height loss on health outcomes has been little studied. We examined the relationships between height loss over 20 years (starting at middle age) and subsequent total mortality and incidence of coronary heart disease and stroke in older men. METHODS: A prospective study was performed on 4213 men whose height was measured between the ages of 40 and 59 years and again 20 years later between the ages of 60 and 79 years. The men were then followed up for a mean period of 6 years, during which 760 deaths occurred. RESULTS: Height loss correlated significantly with initial age (r = 0.20) and weight loss (r = 0.20). Total mortality risk was higher in men with a height loss of 3 cm or more than in men with a height loss of less than 1 cm (age-adjusted relative risk [RR], 1.64; 95% confidence interval [CI], 1.33-2.03). The excess deaths were largely attributable to cardiovascular and respiratory conditions and other causes but not to cancer. Adjustment for age, established cardiovascular risk factors, lung function, preexisting cardiovascular disease, albumin concentration, self-reported poor or fair health, and weight loss had a modest impact on the increased risk of total mortality (RR, 1.45; 95% CI, 1.15-1.82). The risk of major coronary heart disease events was increased only in men with a height loss of 3 cm or more even after adjustment (adjusted RR, 1.42; 95% CI, 1.02-1.98; > or =3.0 cm vs <3.0 cm); no association was seen with stroke risk. CONCLUSION: Marked height loss (> or =3 cm) in older men is independently associated with an increased risk of all-cause mortality and coronary heart disease. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/17159023/Height_loss_in_older_men:_associations_with_total_mortality_and_incidence_of_cardiovascular_disease_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.22.2546 DB - PRIME DP - Unbound Medicine ER -