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Body mass index in older persons is associated with Alzheimer disease pathology.

Abstract

OBJECTIVE

We examined the extent to which body mass index (BMI) in older persons is associated with common age-related neuropathologies known to contribute to dementia including Alzheimer disease (AD) pathology, cerebral infarction, and Lewy body disease.

METHODS

We studied brain autopsies from 298 deceased Catholic clergy participating in the Religious Orders Study, a longitudinal clinical-pathologic investigation. BMI was assessed at annual clinical evaluations during an average follow-up of 4.9 years (SD = 2.7 years). Each person's average BMI, derived from all evaluations, was used in analyses. Multiple regression analyses were used to examine the relation of common postmortem neuropathologic findings to average BMI prior to death.

RESULTS

Mean age at death was 85.7 years (SD = 6.8 years), and average BMI during the course of the study was 26.0 (SD = 5.1). A series of linear regression models was performed with average BMI as the outcome and controlling for age, sex, and education. Level of AD pathology was associated with BMI proximate to death (estimate = -1.15; SE = 0.42; p = 0.007). However, Lewy body pathology (estimate = -0.45; SE = 0.73; p = 0.53) and cerebral infarctions (estimate = -0.10; SE = 0.61; p = 0.88) were not associated with average BMI. The association of AD pathology with BMI was unchanged after controlling for dementia, chronic diseases, and physical activity.

CONCLUSION

Body mass in old age is associated with Alzheimer disease pathology in persons with and without dementia.

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  • Authors+Show Affiliations

    ,

    Rush Alzheimer's Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 S. Paulina St., Chicago, IL 60612, USA. Aron_S_Buchman@rush.edu

    , , ,

    Source

    Neurology 67:11 2006 Dec 12 pg 1949-54

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Body Mass Index
    Cohort Studies
    Dementia
    Female
    Humans
    Longitudinal Studies
    Male
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17159099

    Citation

    Buchman, A S., et al. "Body Mass Index in Older Persons Is Associated With Alzheimer Disease Pathology." Neurology, vol. 67, no. 11, 2006, pp. 1949-54.
    Buchman AS, Schneider JA, Wilson RS, et al. Body mass index in older persons is associated with Alzheimer disease pathology. Neurology. 2006;67(11):1949-54.
    Buchman, A. S., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Bennett, D. A. (2006). Body mass index in older persons is associated with Alzheimer disease pathology. Neurology, 67(11), pp. 1949-54.
    Buchman AS, et al. Body Mass Index in Older Persons Is Associated With Alzheimer Disease Pathology. Neurology. 2006 Dec 12;67(11):1949-54. PubMed PMID: 17159099.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index in older persons is associated with Alzheimer disease pathology. AU - Buchman,A S, AU - Schneider,J A, AU - Wilson,R S, AU - Bienias,J L, AU - Bennett,D A, PY - 2006/12/13/pubmed PY - 2007/1/9/medline PY - 2006/12/13/entrez SP - 1949 EP - 54 JF - Neurology JO - Neurology VL - 67 IS - 11 N2 - OBJECTIVE: We examined the extent to which body mass index (BMI) in older persons is associated with common age-related neuropathologies known to contribute to dementia including Alzheimer disease (AD) pathology, cerebral infarction, and Lewy body disease. METHODS: We studied brain autopsies from 298 deceased Catholic clergy participating in the Religious Orders Study, a longitudinal clinical-pathologic investigation. BMI was assessed at annual clinical evaluations during an average follow-up of 4.9 years (SD = 2.7 years). Each person's average BMI, derived from all evaluations, was used in analyses. Multiple regression analyses were used to examine the relation of common postmortem neuropathologic findings to average BMI prior to death. RESULTS: Mean age at death was 85.7 years (SD = 6.8 years), and average BMI during the course of the study was 26.0 (SD = 5.1). A series of linear regression models was performed with average BMI as the outcome and controlling for age, sex, and education. Level of AD pathology was associated with BMI proximate to death (estimate = -1.15; SE = 0.42; p = 0.007). However, Lewy body pathology (estimate = -0.45; SE = 0.73; p = 0.53) and cerebral infarctions (estimate = -0.10; SE = 0.61; p = 0.88) were not associated with average BMI. The association of AD pathology with BMI was unchanged after controlling for dementia, chronic diseases, and physical activity. CONCLUSION: Body mass in old age is associated with Alzheimer disease pathology in persons with and without dementia. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17159099/Body_mass_index_in_older_persons_is_associated_with_Alzheimer_disease_pathology_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17159099 DB - PRIME DP - Unbound Medicine ER -