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Body mass index and the risk of Parkinson disease.
Neurology. 2006 Dec 12; 67(11):1955-9.Neur

Abstract

OBJECTIVE

To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD).

METHODS

Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI.

RESULTS

During a mean follow-up period of 18.8 years, 272 men and 254 women developed incident PD. After adjustment for confounding factors (age, study years, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, and alcohol, coffee, and tea consumption), the HRs of PD at different levels of BMI (<23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and > or =30 kg/m(2)) were 1.00, 1.97 (95% CI: 1.21 to 3.22), 1.83 (95% CI: 1.12 to 2.99), 2.34 (95% CI: 1.45 to 3.78), and 2.44 (95% CI: 1.44 to 4.15) in men, and 1.00, 1.50 (95% CI: 0.95 to 2.37), 1.65 (95% CI: 1.05 to 2.59), 1.79 (95% CI: 1.15 to 2.80), and 1.77 (95% CI: 1.12 to 2.78) in women, and 1.00, 1.70 (95% CI: 1.23 to 2.37), 1.70 (95% CI: 1.23 to 2.37), 2.02 (95% CI: 1.46 to 2.79), and 2.03 (95% CI: 1.44 to 2.85) in men and women combined (adjusted also for sex). In both sexes combined, the multivariate-adjusted direct association between BMI and the risk of PD was present both in subjects aged 25 to 49 years and 50 to 59 years, in never smokers and smokers and in participants diagnosed PD before and after 65 years of age.

CONCLUSION

Body mass index is associated with a risk of Parkinson disease. The effect is graded and independent of other risk factors.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. hu.gang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17159100

Citation

Hu, G, et al. "Body Mass Index and the Risk of Parkinson Disease." Neurology, vol. 67, no. 11, 2006, pp. 1955-9.
Hu G, Jousilahti P, Nissinen A, et al. Body mass index and the risk of Parkinson disease. Neurology. 2006;67(11):1955-9.
Hu, G., Jousilahti, P., Nissinen, A., Antikainen, R., Kivipelto, M., & Tuomilehto, J. (2006). Body mass index and the risk of Parkinson disease. Neurology, 67(11), 1955-9.
Hu G, et al. Body Mass Index and the Risk of Parkinson Disease. Neurology. 2006 Dec 12;67(11):1955-9. PubMed PMID: 17159100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index and the risk of Parkinson disease. AU - Hu,G, AU - Jousilahti,P, AU - Nissinen,A, AU - Antikainen,R, AU - Kivipelto,M, AU - Tuomilehto,J, PY - 2006/12/13/pubmed PY - 2007/1/9/medline PY - 2006/12/13/entrez SP - 1955 EP - 9 JF - Neurology JO - Neurology VL - 67 IS - 11 N2 - OBJECTIVE: To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS: Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESULTS: During a mean follow-up period of 18.8 years, 272 men and 254 women developed incident PD. After adjustment for confounding factors (age, study years, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, and alcohol, coffee, and tea consumption), the HRs of PD at different levels of BMI (<23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and > or =30 kg/m(2)) were 1.00, 1.97 (95% CI: 1.21 to 3.22), 1.83 (95% CI: 1.12 to 2.99), 2.34 (95% CI: 1.45 to 3.78), and 2.44 (95% CI: 1.44 to 4.15) in men, and 1.00, 1.50 (95% CI: 0.95 to 2.37), 1.65 (95% CI: 1.05 to 2.59), 1.79 (95% CI: 1.15 to 2.80), and 1.77 (95% CI: 1.12 to 2.78) in women, and 1.00, 1.70 (95% CI: 1.23 to 2.37), 1.70 (95% CI: 1.23 to 2.37), 2.02 (95% CI: 1.46 to 2.79), and 2.03 (95% CI: 1.44 to 2.85) in men and women combined (adjusted also for sex). In both sexes combined, the multivariate-adjusted direct association between BMI and the risk of PD was present both in subjects aged 25 to 49 years and 50 to 59 years, in never smokers and smokers and in participants diagnosed PD before and after 65 years of age. CONCLUSION: Body mass index is associated with a risk of Parkinson disease. The effect is graded and independent of other risk factors. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17159100/Body_mass_index_and_the_risk_of_Parkinson_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=17159100 DB - PRIME DP - Unbound Medicine ER -