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[Scleroderma renal crisis].
Presse Med. 2006 Dec; 35(12 Pt 2):1966-74.PM

Abstract

Scleroderma renal crisis (SRC) occurs in patients with systemic sclerosis (SSc) and is defined by otherwise unexplained rapidly progressive renal insufficiency associated with oliguria or rapidly progressive arterial hypertension or both. SRC is a rare and severe complication of SSc, most often encountered during the first 4 years of disease, almost only in patients with diffuse SSc. Factors predicting SRC were identified, including high-dose corticosteroid administration. Use of angiotensin-converting enzyme inhibitors (ACEI) has dramatically impressed the prognosis of SRC, but it mortality rate is still high. Treatment aims at normalizing blood pressure as soon as possible. ACEI should always be used, and additional anti-hypertensive agents, including calcium channel blockers and alpha- and beta-blockers, may be useful. Renal replacement therapy may be needed, but often (for almost half of patients) only temporarily.

Authors+Show Affiliations

Service de Médecine Interne, Hôpital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique-Hôpitaux de Paris (AP-HP) et Université Paris-Descartes, Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

fre

PubMed ID

17159723

Citation

Teixeira, Luis, et al. "[Scleroderma Renal Crisis]." Presse Medicale (Paris, France : 1983), vol. 35, no. 12 Pt 2, 2006, pp. 1966-74.
Teixeira L, Servettaz A, Mehrenberger M, et al. [Scleroderma renal crisis]. Presse Med. 2006;35(12 Pt 2):1966-74.
Teixeira, L., Servettaz, A., Mehrenberger, M., Noël, L. H., Guillevin, L., & Mouthon, L. (2006). [Scleroderma renal crisis]. Presse Medicale (Paris, France : 1983), 35(12 Pt 2), 1966-74.
Teixeira L, et al. [Scleroderma Renal Crisis]. Presse Med. 2006;35(12 Pt 2):1966-74. PubMed PMID: 17159723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Scleroderma renal crisis]. AU - Teixeira,Luis, AU - Servettaz,Amélie, AU - Mehrenberger,Marion, AU - Noël,Laure-Hélène, AU - Guillevin,Loïc, AU - Mouthon,Luc, PY - 2006/12/13/pubmed PY - 2007/1/20/medline PY - 2006/12/13/entrez SP - 1966 EP - 74 JF - Presse medicale (Paris, France : 1983) JO - Presse Med VL - 35 IS - 12 Pt 2 N2 - Scleroderma renal crisis (SRC) occurs in patients with systemic sclerosis (SSc) and is defined by otherwise unexplained rapidly progressive renal insufficiency associated with oliguria or rapidly progressive arterial hypertension or both. SRC is a rare and severe complication of SSc, most often encountered during the first 4 years of disease, almost only in patients with diffuse SSc. Factors predicting SRC were identified, including high-dose corticosteroid administration. Use of angiotensin-converting enzyme inhibitors (ACEI) has dramatically impressed the prognosis of SRC, but it mortality rate is still high. Treatment aims at normalizing blood pressure as soon as possible. ACEI should always be used, and additional anti-hypertensive agents, including calcium channel blockers and alpha- and beta-blockers, may be useful. Renal replacement therapy may be needed, but often (for almost half of patients) only temporarily. SN - 0755-4982 UR - https://www.unboundmedicine.com/medline/citation/17159723/[Scleroderma_renal_crisis]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0755-4982(06)74931-4 DB - PRIME DP - Unbound Medicine ER -