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Gene frequencies of human platelet alloantigens in Bahraini Arabs.
Am J Hematol. 2007 Mar; 82(3):242-4.AJ

Abstract

Human platelet antigens (HPA) are implicated in the pathophysiology of certain hematological disorders, and as varied distribution of HPA-1 alleles and genotypes were reported fordifferent countries and ethnic populations, we determined the distribution of HPA-1, -2, -3, -4, and -5 alleles, genotypes and haplotypes for 194 healthy Bahraini subjects by polymerase chain reaction with sequence specific primers. The distribution of the HPA polymorphisms was in Hardy-Weinberg equilibrium. Allele frequencies of 0.76 and 0.24 (HPA-1a and -1b), 0.77 and 0.23 (HPA-2a and -2b), 0.57 and 0.43 (HPA-3a and -3b), 0.93 and 0.07 (HPA-4a and -4b), and 0.86 and 0.13 (HPA-5a and -5b) were seen. With the exception of HPA-3a/a (30.4%), the frequencies of homozygous HPA-1a/a (56.8%), 2a/a (60.1%), 4a/a (87.2%), and 5a/a (75.7%) were higher than those of heterozygous (a/b) or homozygous (b/b) variants. Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune-mediated platelet disorders.

Authors+Show Affiliations

Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17160992

Citation

Al-Subaie, Abeer M., et al. "Gene Frequencies of Human Platelet Alloantigens in Bahraini Arabs." American Journal of Hematology, vol. 82, no. 3, 2007, pp. 242-4.
Al-Subaie AM, Al-Absi IK, Al-Ola K, et al. Gene frequencies of human platelet alloantigens in Bahraini Arabs. Am J Hematol. 2007;82(3):242-4.
Al-Subaie, A. M., Al-Absi, I. K., Al-Ola, K., Saidi, S., Fawaz, N. A., & Almawi, W. Y. (2007). Gene frequencies of human platelet alloantigens in Bahraini Arabs. American Journal of Hematology, 82(3), 242-4.
Al-Subaie AM, et al. Gene Frequencies of Human Platelet Alloantigens in Bahraini Arabs. Am J Hematol. 2007;82(3):242-4. PubMed PMID: 17160992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene frequencies of human platelet alloantigens in Bahraini Arabs. AU - Al-Subaie,Abeer M, AU - Al-Absi,Iman K, AU - Al-Ola,Khadija, AU - Saidi,Sarra, AU - Fawaz,Naglaa A, AU - Almawi,Wassim Y, PY - 2006/12/13/pubmed PY - 2007/4/14/medline PY - 2006/12/13/entrez SP - 242 EP - 4 JF - American journal of hematology JO - Am. J. Hematol. VL - 82 IS - 3 N2 - Human platelet antigens (HPA) are implicated in the pathophysiology of certain hematological disorders, and as varied distribution of HPA-1 alleles and genotypes were reported fordifferent countries and ethnic populations, we determined the distribution of HPA-1, -2, -3, -4, and -5 alleles, genotypes and haplotypes for 194 healthy Bahraini subjects by polymerase chain reaction with sequence specific primers. The distribution of the HPA polymorphisms was in Hardy-Weinberg equilibrium. Allele frequencies of 0.76 and 0.24 (HPA-1a and -1b), 0.77 and 0.23 (HPA-2a and -2b), 0.57 and 0.43 (HPA-3a and -3b), 0.93 and 0.07 (HPA-4a and -4b), and 0.86 and 0.13 (HPA-5a and -5b) were seen. With the exception of HPA-3a/a (30.4%), the frequencies of homozygous HPA-1a/a (56.8%), 2a/a (60.1%), 4a/a (87.2%), and 5a/a (75.7%) were higher than those of heterozygous (a/b) or homozygous (b/b) variants. Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune-mediated platelet disorders. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/17160992/Gene_frequencies_of_human_platelet_alloantigens_in_Bahraini_Arabs_ L2 - https://doi.org/10.1002/ajh.20769 DB - PRIME DP - Unbound Medicine ER -