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Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis.
J Am Coll Cardiol 2006; 48(11):2285-92JACC

Abstract

OBJECTIVES

The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA).

BACKGROUND

Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease.

METHODS

Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output.

RESULTS

The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively).

CONCLUSIONS

In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.

Authors+Show Affiliations

Department of Epidemiology, University of Washington, Seattle, Washington 98101-1448, USA. heckbert@u.washington.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17161261

Citation

Heckbert, Susan R., et al. "Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function By Cardiac Magnetic Resonance Imaging: the Multiethnic Study of Atherosclerosis." Journal of the American College of Cardiology, vol. 48, no. 11, 2006, pp. 2285-92.
Heckbert SR, Post W, Pearson GD, et al. Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. J Am Coll Cardiol. 2006;48(11):2285-92.
Heckbert, S. R., Post, W., Pearson, G. D., Arnett, D. K., Gomes, A. S., Jerosch-Herold, M., ... Bluemke, D. A. (2006). Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. Journal of the American College of Cardiology, 48(11), pp. 2285-92.
Heckbert SR, et al. Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function By Cardiac Magnetic Resonance Imaging: the Multiethnic Study of Atherosclerosis. J Am Coll Cardiol. 2006 Dec 5;48(11):2285-92. PubMed PMID: 17161261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. AU - Heckbert,Susan R, AU - Post,Wendy, AU - Pearson,Gregory D N, AU - Arnett,Donna K, AU - Gomes,Antoinette S, AU - Jerosch-Herold,Michael, AU - Hundley,W Gregory, AU - Lima,Joao A, AU - Bluemke,David A, Y1 - 2006/11/09/ PY - 2006/01/19/received PY - 2006/03/20/revised PY - 2006/03/30/accepted PY - 2006/12/13/pubmed PY - 2007/1/12/medline PY - 2006/12/13/entrez SP - 2285 EP - 92 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 48 IS - 11 N2 - OBJECTIVES: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). BACKGROUND: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. METHODS: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. RESULTS: The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively). CONCLUSIONS: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/17161261/Traditional_cardiovascular_risk_factors_in_relation_to_left_ventricular_mass_volume_and_systolic_function_by_cardiac_magnetic_resonance_imaging:_the_Multiethnic_Study_of_Atherosclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)02208-X DB - PRIME DP - Unbound Medicine ER -