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Extended oligoarthritis and other risk factors for developing JIA-associated uveitis under ILAR classification and its implication for current screening guideline.
Ocul Immunol Inflamm. 2006 Dec; 14(6):353-7.OI

Abstract

PURPOSE

To investigate the risk factors for developing uveitis in a regional cohort of patients with juvenile idiopathic arthritis (JIA) as classified under ILAR criteria.

PATIENTS AND METHODS

The clinical factors for developing uveitis and its visual outcome were studied retrospectively for all children diagnosed with JIA at Nottingham University Hospital, England from 1974 to 2001.

RESULTS

A total of 202 patients with juvenile idiopathic arthritis were identified. Twenty-three patients (11.4%) were found to have uveitis. The mean age of arthritis onset in those with uveitis was 4.9 (95% CI 3.4-6.4) and in those without uveitis was 7.6 (95% CI 7.0-8.3), p = 0.002. Both the persistent and extended oligoarthritis groups are at significant risk of developing uveitis on Kaplan-Meier analysis with p = 0.001 and 0.013, respectively, compared to other ILAR subtypes. Extended oligoarthritis (1 to 4 joints affected in first 6 months of disease but 5 or more cumulative joints after first 6 months) had the highest prevalence of uveitis (25%) among the ILAR subtypes. Patients with extended oligoarthritis also developed uveitis earlier than persistent group, p = 0.017. Gender, race, and antinuclear antibody (ANA) status were not significant risk factors. The visual outcome was favorable, with 90% achieving acuity of 6/12 or better.

CONCLUSION

Patients with extended oligoarthritis are at higher risk and have a shorter interval from diagnosis of arthritis to development of uveitis and need to be monitored more closely. Screening guideline for JIA-associated uveitis based on ILAR classification is called for.

Authors+Show Affiliations

Sim KT
Queens Medical Centre, Department of Ophthalmology and Visual Science, Nottingham, UK. kuantzen@doctors.org.uk
Venning HE
No affiliation info available
Barrett S
No affiliation info available
Gregson RM
No affiliation info available
Amoaku WM
No affiliation info available

MeSH

AdolescentAge DistributionArthritis, JuvenileChildChild, PreschoolEnglandFemaleFollow-Up StudiesHumansInfantMalePractice Guidelines as TopicPrevalencePrognosisRetrospective StudiesRisk FactorsSex DistributionUveitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17162606

Citation

Sim, Kuan T., et al. "Extended Oligoarthritis and Other Risk Factors for Developing JIA-associated Uveitis Under ILAR Classification and Its Implication for Current Screening Guideline." Ocular Immunology and Inflammation, vol. 14, no. 6, 2006, pp. 353-7.
Sim KT, Venning HE, Barrett S, et al. Extended oligoarthritis and other risk factors for developing JIA-associated uveitis under ILAR classification and its implication for current screening guideline. Ocul Immunol Inflamm. 2006;14(6):353-7.
Sim, K. T., Venning, H. E., Barrett, S., Gregson, R. M., & Amoaku, W. M. (2006). Extended oligoarthritis and other risk factors for developing JIA-associated uveitis under ILAR classification and its implication for current screening guideline. Ocular Immunology and Inflammation, 14(6), 353-7.
Sim KT, et al. Extended Oligoarthritis and Other Risk Factors for Developing JIA-associated Uveitis Under ILAR Classification and Its Implication for Current Screening Guideline. Ocul Immunol Inflamm. 2006;14(6):353-7. PubMed PMID: 17162606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extended oligoarthritis and other risk factors for developing JIA-associated uveitis under ILAR classification and its implication for current screening guideline. AU - Sim,Kuan T, AU - Venning,Helen E, AU - Barrett,Steve, AU - Gregson,Richard M, AU - Amoaku,Winfred M, PY - 2006/12/13/pubmed PY - 2007/2/3/medline PY - 2006/12/13/entrez SP - 353 EP - 7 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 14 IS - 6 N2 - PURPOSE: To investigate the risk factors for developing uveitis in a regional cohort of patients with juvenile idiopathic arthritis (JIA) as classified under ILAR criteria. PATIENTS AND METHODS: The clinical factors for developing uveitis and its visual outcome were studied retrospectively for all children diagnosed with JIA at Nottingham University Hospital, England from 1974 to 2001. RESULTS: A total of 202 patients with juvenile idiopathic arthritis were identified. Twenty-three patients (11.4%) were found to have uveitis. The mean age of arthritis onset in those with uveitis was 4.9 (95% CI 3.4-6.4) and in those without uveitis was 7.6 (95% CI 7.0-8.3), p = 0.002. Both the persistent and extended oligoarthritis groups are at significant risk of developing uveitis on Kaplan-Meier analysis with p = 0.001 and 0.013, respectively, compared to other ILAR subtypes. Extended oligoarthritis (1 to 4 joints affected in first 6 months of disease but 5 or more cumulative joints after first 6 months) had the highest prevalence of uveitis (25%) among the ILAR subtypes. Patients with extended oligoarthritis also developed uveitis earlier than persistent group, p = 0.017. Gender, race, and antinuclear antibody (ANA) status were not significant risk factors. The visual outcome was favorable, with 90% achieving acuity of 6/12 or better. CONCLUSION: Patients with extended oligoarthritis are at higher risk and have a shorter interval from diagnosis of arthritis to development of uveitis and need to be monitored more closely. Screening guideline for JIA-associated uveitis based on ILAR classification is called for. SN - 0927-3948 UR - https://www.unboundmedicine.com/medline/citation/17162606/Extended_oligoarthritis_and_other_risk_factors_for_developing_JIA_associated_uveitis_under_ILAR_classification_and_its_implication_for_current_screening_guideline_ DB - PRIME DP - Unbound Medicine ER -