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Metformin reduces abortion in pregnant women with polycystic ovary syndrome.
Gynecol Endocrinol 2006; 22(12):680-4GE

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) are considered to be at increased risk of miscarriage. Since metformin has beneficial effects on the risk factors contributing to first-trimester abortion in PCOS patients, we hypothesized that metformin - owing to its metabolic, endocrine, vascular and anti-inflammatory effects - may reduce the incidence of first-trimester abortion in PCOS women.

MATERIALS AND METHODS

A prospective cohort study was set up to determine the beneficial effects of metformin on PCOS patients during pregnancy. Two hundred non-diabetic PCOS patients were evaluated while undergoing assisted reproduction. One hundred and twenty patients became pregnant while taking metformin, and continued taking metformin at a dose of 1000-2000 mg daily throughout pregnancy. Eighty women who discontinued metformin use at the time of conception or during pregnancy comprised the control group.

RESULTS

Both groups were similar with respect to all background characteristics (age, body mass index, waist/hip ratio, follicle-stimulating hormone, luteinizing hormone, estradiol and dehydroepiandrosterone sulfate levels). Rates of early pregnancy loss in the metformin group were 11.6% compared with 36.3% in the control group (p < 0.0001; odds ratio = 0.23, 95% confidence interval 0.11-0.42).

CONCLUSIONS

Administration of metformin throughout pregnancy to women with PCOS was associated with a marked and significant reduction in the rate of early pregnancy loss.

Authors+Show Affiliations

Misr International Infertility & IVF Center, Misr International Hospital, Department of Obstetrics & Gynecology, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17162710

Citation

Khattab, Sherif, et al. "Metformin Reduces Abortion in Pregnant Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 22, no. 12, 2006, pp. 680-4.
Khattab S, Mohsen IA, Foutouh IA, et al. Metformin reduces abortion in pregnant women with polycystic ovary syndrome. Gynecol Endocrinol. 2006;22(12):680-4.
Khattab, S., Mohsen, I. A., Foutouh, I. A., Ramadan, A., Moaz, M., & Al-Inany, H. (2006). Metformin reduces abortion in pregnant women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 22(12), pp. 680-4.
Khattab S, et al. Metformin Reduces Abortion in Pregnant Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2006;22(12):680-4. PubMed PMID: 17162710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metformin reduces abortion in pregnant women with polycystic ovary syndrome. AU - Khattab,Sherif, AU - Mohsen,Iman Abdel, AU - Foutouh,Ismail Aboul, AU - Ramadan,Ashraf, AU - Moaz,Mohamed, AU - Al-Inany,Hesham, PY - 2006/12/13/pubmed PY - 2007/2/10/medline PY - 2006/12/13/entrez SP - 680 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 22 IS - 12 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) are considered to be at increased risk of miscarriage. Since metformin has beneficial effects on the risk factors contributing to first-trimester abortion in PCOS patients, we hypothesized that metformin - owing to its metabolic, endocrine, vascular and anti-inflammatory effects - may reduce the incidence of first-trimester abortion in PCOS women. MATERIALS AND METHODS: A prospective cohort study was set up to determine the beneficial effects of metformin on PCOS patients during pregnancy. Two hundred non-diabetic PCOS patients were evaluated while undergoing assisted reproduction. One hundred and twenty patients became pregnant while taking metformin, and continued taking metformin at a dose of 1000-2000 mg daily throughout pregnancy. Eighty women who discontinued metformin use at the time of conception or during pregnancy comprised the control group. RESULTS: Both groups were similar with respect to all background characteristics (age, body mass index, waist/hip ratio, follicle-stimulating hormone, luteinizing hormone, estradiol and dehydroepiandrosterone sulfate levels). Rates of early pregnancy loss in the metformin group were 11.6% compared with 36.3% in the control group (p < 0.0001; odds ratio = 0.23, 95% confidence interval 0.11-0.42). CONCLUSIONS: Administration of metformin throughout pregnancy to women with PCOS was associated with a marked and significant reduction in the rate of early pregnancy loss. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/17162710/Metformin_reduces_abortion_in_pregnant_women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590601010508 DB - PRIME DP - Unbound Medicine ER -