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[Iron status with particular consideration of soluble transferrin receptors in children and youth with gastritis, with or without Helicobacter pylori infection].
Pol Merkur Lekarski. 2006 Sep; 21(123):235-8.PM

Abstract

Role of Helicobacter pylori infection in chronic gastritis and gastric and/or duodenal ulcers is well known. Simultaneously there are some articles in literature considering H. pylori as a cause of extra-gastrointestinal illnesses such as atopic dermatitis, chronic urticaria or acne rosacea, hypotrophy, Schoenlein-Henoch disease, atherosclerosis or hypochromic anaemia. The aim of the study. was to asses iron status in aspect of plasmatic transferrin receptors concentration among children and youth with chronic gastritis with or without Helicobacter pylori infection.

MATERIALS AND METHODS

Forty one patients were included as a study group. Range of age was 9-18 years. All patients were diagnosed due to chronic abdominal pains. There were 13 males and 28 females. Blood was collected from every patient for blood cell count, iron, transferrin and transferrin receptors concentration (sTfR) assessment before endoscopy of upper gastrointestinal tract.

RESULTS

Concentration of sTfR was higher than age norm among 29 (71%) of patients. Among patients with higher level of sTfR 20 (69%) had normal haemoglobin concentration and in this group 10 patients had H. pylori infection. During analysis of 12 patients with nornal level of sTfR normal haemoglobin concentration was found and among five of them H. pylori infection was stated. Among 21 patients without H. pylori infection 14 had normal level of sTfR and 7 had higher level of sTfR which means that 33% had hidden iron deficiency (involuntary of normal Hb concentrations). Among 15 of 20 patients with H. pylori infection level of sTfR was higher which means that 75% patients with infection had hidden iron deficiency (involuntary of normal Hb concentrations).

CONCLUSION

Level of plasmatic transferrin receptors can be good and sensitive indicator of iron deficiency and can be helpful in differential diagnosis of hypochromic anaemia and anaemia caused by chronic illness including chronic gastritis with Helicobacter pylori infection.

Authors+Show Affiliations

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy. klped@cm.umk.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

pol

PubMed ID

17163184

Citation

Mierzwa, Grazyna, et al. "[Iron Status With Particular Consideration of Soluble Transferrin Receptors in Children and Youth With Gastritis, With or Without Helicobacter Pylori Infection]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 21, no. 123, 2006, pp. 235-8.
Mierzwa G, Augustyńska B, Czerwionka-Szaflarska M, et al. [Iron status with particular consideration of soluble transferrin receptors in children and youth with gastritis, with or without Helicobacter pylori infection]. Pol Merkur Lekarski. 2006;21(123):235-8.
Mierzwa, G., Augustyńska, B., Czerwionka-Szaflarska, M., & Tyrakowski, T. (2006). [Iron status with particular consideration of soluble transferrin receptors in children and youth with gastritis, with or without Helicobacter pylori infection]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 21(123), 235-8.
Mierzwa G, et al. [Iron Status With Particular Consideration of Soluble Transferrin Receptors in Children and Youth With Gastritis, With or Without Helicobacter Pylori Infection]. Pol Merkur Lekarski. 2006;21(123):235-8. PubMed PMID: 17163184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Iron status with particular consideration of soluble transferrin receptors in children and youth with gastritis, with or without Helicobacter pylori infection]. AU - Mierzwa,Grazyna, AU - Augustyńska,Beata, AU - Czerwionka-Szaflarska,Mieczysława, AU - Tyrakowski,Tomasz, PY - 2006/12/14/pubmed PY - 2007/2/23/medline PY - 2006/12/14/entrez SP - 235 EP - 8 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol Merkur Lekarski VL - 21 IS - 123 N2 - UNLABELLED: Role of Helicobacter pylori infection in chronic gastritis and gastric and/or duodenal ulcers is well known. Simultaneously there are some articles in literature considering H. pylori as a cause of extra-gastrointestinal illnesses such as atopic dermatitis, chronic urticaria or acne rosacea, hypotrophy, Schoenlein-Henoch disease, atherosclerosis or hypochromic anaemia. The aim of the study. was to asses iron status in aspect of plasmatic transferrin receptors concentration among children and youth with chronic gastritis with or without Helicobacter pylori infection. MATERIALS AND METHODS: Forty one patients were included as a study group. Range of age was 9-18 years. All patients were diagnosed due to chronic abdominal pains. There were 13 males and 28 females. Blood was collected from every patient for blood cell count, iron, transferrin and transferrin receptors concentration (sTfR) assessment before endoscopy of upper gastrointestinal tract. RESULTS: Concentration of sTfR was higher than age norm among 29 (71%) of patients. Among patients with higher level of sTfR 20 (69%) had normal haemoglobin concentration and in this group 10 patients had H. pylori infection. During analysis of 12 patients with nornal level of sTfR normal haemoglobin concentration was found and among five of them H. pylori infection was stated. Among 21 patients without H. pylori infection 14 had normal level of sTfR and 7 had higher level of sTfR which means that 33% had hidden iron deficiency (involuntary of normal Hb concentrations). Among 15 of 20 patients with H. pylori infection level of sTfR was higher which means that 75% patients with infection had hidden iron deficiency (involuntary of normal Hb concentrations). CONCLUSION: Level of plasmatic transferrin receptors can be good and sensitive indicator of iron deficiency and can be helpful in differential diagnosis of hypochromic anaemia and anaemia caused by chronic illness including chronic gastritis with Helicobacter pylori infection. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/17163184/[Iron_status_with_particular_consideration_of_soluble_transferrin_receptors_in_children_and_youth_with_gastritis_with_or_without_Helicobacter_pylori_infection]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -