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Lessons learned from reconstructing the 1918 influenza pandemic.
J Infect Dis. 2006 Nov 01; 194 Suppl 2:S127-32.JI

Abstract

The "Spanish influenza" pandemic of 1918 was the most devastating influenza epidemic reported in history and killed >30 million people worldwide. The factors contributing to the severe pathogenicity of this influenza virus are of great interest, because avian influenza viruses circulating today pose the threat of a new pandemic if they develop sustained human-to-human transmissibility. Recent characterization of the 1918 virus has illuminated which determinants may be the cause of virulence. Here, we wish to shed light on what has been learned to date about the 1918 virus with regard to pathogenicity and transmissibility, to supplement our understanding of the determinants of human virulence and transmission of pandemic influenza viruses. Monitoring the sequences of avian influenza viruses for genetic changes and diversity may help us to predict the risks that these viruses pose of causing a new pandemic.

Authors+Show Affiliations

Department of Microbiology, Mount Sinai School of Medicine, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17163385

Citation

Garcia-Sastre, Adolfo, and Richard J. Whitley. "Lessons Learned From Reconstructing the 1918 Influenza Pandemic." The Journal of Infectious Diseases, vol. 194 Suppl 2, 2006, pp. S127-32.
Garcia-Sastre A, Whitley RJ. Lessons learned from reconstructing the 1918 influenza pandemic. J Infect Dis. 2006;194 Suppl 2:S127-32.
Garcia-Sastre, A., & Whitley, R. J. (2006). Lessons learned from reconstructing the 1918 influenza pandemic. The Journal of Infectious Diseases, 194 Suppl 2, S127-32.
Garcia-Sastre A, Whitley RJ. Lessons Learned From Reconstructing the 1918 Influenza Pandemic. J Infect Dis. 2006 Nov 1;194 Suppl 2:S127-32. PubMed PMID: 17163385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lessons learned from reconstructing the 1918 influenza pandemic. AU - Garcia-Sastre,Adolfo, AU - Whitley,Richard J, PY - 2006/12/14/pubmed PY - 2007/4/6/medline PY - 2006/12/14/entrez SP - S127 EP - 32 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 194 Suppl 2 N2 - The "Spanish influenza" pandemic of 1918 was the most devastating influenza epidemic reported in history and killed >30 million people worldwide. The factors contributing to the severe pathogenicity of this influenza virus are of great interest, because avian influenza viruses circulating today pose the threat of a new pandemic if they develop sustained human-to-human transmissibility. Recent characterization of the 1918 virus has illuminated which determinants may be the cause of virulence. Here, we wish to shed light on what has been learned to date about the 1918 virus with regard to pathogenicity and transmissibility, to supplement our understanding of the determinants of human virulence and transmission of pandemic influenza viruses. Monitoring the sequences of avian influenza viruses for genetic changes and diversity may help us to predict the risks that these viruses pose of causing a new pandemic. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/17163385/Lessons_learned_from_reconstructing_the_1918_influenza_pandemic_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/507546 DB - PRIME DP - Unbound Medicine ER -