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Reduced aortic wall stress in diabetes mellitus.
Eur J Vasc Endovasc Surg. 2007 May; 33(5):592-8.EJ

Abstract

OBJECTIVE

Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be an etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls.

METHODS

39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness (IMT) in the abdominal aorta (AA) and the common carotid artery (CCA). Diastolic blood pressure (DBP) was measured non-invasively in the brachial artery. LaPlace law was used to calculate circumferential wall stress.

RESULTS

Age, DBP, and LD in the abdominal aorta were not significantly different in the diabetic patients compared to controls. IMT in the AA was larger in the diabetic patients, 0.89+/-0.17 vs 0.73+/-0.11 mm (p<.001). Accordingly aortic wall stress was reduced in the diabetics, 7.8+/-1.7 x 10(5) vs 9.7+/-1.9 x 10(5)dynes/cm(2) (p<.001).

CONCLUSIONS

Wall stress in the abdominal aorta is reduced in diabetes mellitus. This is mainly due to a thicker aortic wall compared to healthy controls. The reduced aortic wall stress coincides with the fact that epidemiological studies have shown a decreased risk of aneurysm development in diabetic patients.

Authors+Show Affiliations

Department of Medicine and Care, University of Linköping, Division of Vascular Surgery, Jönköping Hospital, Sweden. hakan.astrand@lj.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17164093

Citation

Astrand, H, et al. "Reduced Aortic Wall Stress in Diabetes Mellitus." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 33, no. 5, 2007, pp. 592-8.
Astrand H, Rydén-Ahlgren A, Sundkvist G, et al. Reduced aortic wall stress in diabetes mellitus. Eur J Vasc Endovasc Surg. 2007;33(5):592-8.
Astrand, H., Rydén-Ahlgren, A., Sundkvist, G., Sandgren, T., & Länne, T. (2007). Reduced aortic wall stress in diabetes mellitus. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 33(5), 592-8.
Astrand H, et al. Reduced Aortic Wall Stress in Diabetes Mellitus. Eur J Vasc Endovasc Surg. 2007;33(5):592-8. PubMed PMID: 17164093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced aortic wall stress in diabetes mellitus. AU - Astrand,H, AU - Rydén-Ahlgren,A, AU - Sundkvist,G, AU - Sandgren,T, AU - Länne,T, Y1 - 2006/12/11/ PY - 2006/08/18/received PY - 2006/11/16/accepted PY - 2006/12/14/pubmed PY - 2007/6/21/medline PY - 2006/12/14/entrez SP - 592 EP - 8 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 33 IS - 5 N2 - OBJECTIVE: Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be an etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls. METHODS: 39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness (IMT) in the abdominal aorta (AA) and the common carotid artery (CCA). Diastolic blood pressure (DBP) was measured non-invasively in the brachial artery. LaPlace law was used to calculate circumferential wall stress. RESULTS: Age, DBP, and LD in the abdominal aorta were not significantly different in the diabetic patients compared to controls. IMT in the AA was larger in the diabetic patients, 0.89+/-0.17 vs 0.73+/-0.11 mm (p<.001). Accordingly aortic wall stress was reduced in the diabetics, 7.8+/-1.7 x 10(5) vs 9.7+/-1.9 x 10(5)dynes/cm(2) (p<.001). CONCLUSIONS: Wall stress in the abdominal aorta is reduced in diabetes mellitus. This is mainly due to a thicker aortic wall compared to healthy controls. The reduced aortic wall stress coincides with the fact that epidemiological studies have shown a decreased risk of aneurysm development in diabetic patients. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/17164093/Reduced_aortic_wall_stress_in_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(06)00660-5 DB - PRIME DP - Unbound Medicine ER -