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Family history of cancer and the risk of renal cell cancer.
Cancer Epidemiol Biomarkers Prev 2006; 15(12):2441-4CE

Abstract

Only scant information is available on the association between family history of kidney cancer and risk of renal cell cancer (RCC), particularly as concerns the variation of the risk according to sex, age, and type of relative or the association of family history of other cancers with RCC. We thus investigated the issue using data from a large multicentric case-control study conducted in Italy between 1992 and 2004 on 767 patients (494 men and 273 women) under age 80 years, with incident, histologically confirmed RCC, and 1,534 controls under age 80 years, admitted to hospital for a wide spectrum of acute, nonneoplastic conditions and frequency matched 2:1 to cases by center, sex, and age. Conditional logistic regression models, conditioned on center, sex, and age and adjusted for year of interview, smoking, body mass index, and number of brothers and sisters were used to estimate odds ratios (OR). Eighteen RCC and 8 controls reported a family history of kidney cancer in one first-degree relative [OR, 5.2; 95% confidence interval (95% CI), 2.2-12.2]. No significant heterogeneity emerged according to sex or age of the proband or of the affected relative, or smoking habits, body mass index, and history of hypertension of the proband. Although not significant, the OR was higher when the affected relative was a sibling (OR, 7.0; 95% CI, 1.8-27.7) rather than a parent or child (OR, 4.3; 95% CI, 1.5-12.9), as suggested from previous studies. The OR of RCC was also significantly elevated for a family history of prostate cancer (OR, 1.9), leukemias (OR, 2.2), or any cancer (OR, 1.5).

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157 Milano, Italy. evanegri@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17164368

Citation

Negri, Eva, et al. "Family History of Cancer and the Risk of Renal Cell Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 12, 2006, pp. 2441-4.
Negri E, Foschi R, Talamini R, et al. Family history of cancer and the risk of renal cell cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2441-4.
Negri, E., Foschi, R., Talamini, R., Montella, M., Ramazzotti, V., Dal Maso, L., ... La Vecchia, C. (2006). Family history of cancer and the risk of renal cell cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(12), pp. 2441-4.
Negri E, et al. Family History of Cancer and the Risk of Renal Cell Cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2441-4. PubMed PMID: 17164368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of cancer and the risk of renal cell cancer. AU - Negri,Eva, AU - Foschi,Roberto, AU - Talamini,Renato, AU - Montella,Maurizio, AU - Ramazzotti,Valerio, AU - Dal Maso,Luigino, AU - Bosetti,Cristina, AU - Franceschi,Silvia, AU - Zucchetto,Antonella, AU - La Vecchia,Carlo, PY - 2006/12/14/pubmed PY - 2007/4/10/medline PY - 2006/12/14/entrez SP - 2441 EP - 4 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 12 N2 - Only scant information is available on the association between family history of kidney cancer and risk of renal cell cancer (RCC), particularly as concerns the variation of the risk according to sex, age, and type of relative or the association of family history of other cancers with RCC. We thus investigated the issue using data from a large multicentric case-control study conducted in Italy between 1992 and 2004 on 767 patients (494 men and 273 women) under age 80 years, with incident, histologically confirmed RCC, and 1,534 controls under age 80 years, admitted to hospital for a wide spectrum of acute, nonneoplastic conditions and frequency matched 2:1 to cases by center, sex, and age. Conditional logistic regression models, conditioned on center, sex, and age and adjusted for year of interview, smoking, body mass index, and number of brothers and sisters were used to estimate odds ratios (OR). Eighteen RCC and 8 controls reported a family history of kidney cancer in one first-degree relative [OR, 5.2; 95% confidence interval (95% CI), 2.2-12.2]. No significant heterogeneity emerged according to sex or age of the proband or of the affected relative, or smoking habits, body mass index, and history of hypertension of the proband. Although not significant, the OR was higher when the affected relative was a sibling (OR, 7.0; 95% CI, 1.8-27.7) rather than a parent or child (OR, 4.3; 95% CI, 1.5-12.9), as suggested from previous studies. The OR of RCC was also significantly elevated for a family history of prostate cancer (OR, 1.9), leukemias (OR, 2.2), or any cancer (OR, 1.5). SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17164368/Family_history_of_cancer_and_the_risk_of_renal_cell_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17164368 DB - PRIME DP - Unbound Medicine ER -