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Increase in invasive pneumococcal disease in children associated with shortage of heptavalent pneumococcal conjugate vaccine.
Clin Pediatr (Phila). 2007 Jan; 46(1):45-52.CPed

Abstract

The authors investigated the impact of heptavalent pneumococcal conjugate vaccine (PCV7) shortage on the rate of invasive pneumococcal disease (IPD). Vaccination status and number of doses delivered was determined. Regression analysis using an exponential decay model was used to predict the expected rate of IPD in the shortage period if IPD continued to decline at the same rate as in the availability period. The rate of IPD decreased from 15.5 to 6.5 with vaccine availability (P < .00001) and increased to 7.2 with shortage (P = .69). Based on the model, IPD rate would have been 3.6 if the decrease continued at the same rate when there was no shortage; this was statistically significant (95% prediction interval, 2.7-4.1). The rate of IPD correlated directly with the number of PCV7 doses delivered, r = -.98. Continuous availability of the PCV7 would have resulted in a statistically significant lower IPD rate compared to the measured IPD rate in the vaccine shortage period.

Authors+Show Affiliations

Pediatric Infectious Diseases and Immunology, University of Florida Health Science Center, Jacksonville, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17164509

Citation

Abuelreish, Motasem, et al. "Increase in Invasive Pneumococcal Disease in Children Associated With Shortage of Heptavalent Pneumococcal Conjugate Vaccine." Clinical Pediatrics, vol. 46, no. 1, 2007, pp. 45-52.
Abuelreish M, Subedar A, Chiu T, et al. Increase in invasive pneumococcal disease in children associated with shortage of heptavalent pneumococcal conjugate vaccine. Clin Pediatr (Phila). 2007;46(1):45-52.
Abuelreish, M., Subedar, A., Chiu, T., Wludyka, P., & Rathore, M. (2007). Increase in invasive pneumococcal disease in children associated with shortage of heptavalent pneumococcal conjugate vaccine. Clinical Pediatrics, 46(1), 45-52.
Abuelreish M, et al. Increase in Invasive Pneumococcal Disease in Children Associated With Shortage of Heptavalent Pneumococcal Conjugate Vaccine. Clin Pediatr (Phila). 2007;46(1):45-52. PubMed PMID: 17164509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in invasive pneumococcal disease in children associated with shortage of heptavalent pneumococcal conjugate vaccine. AU - Abuelreish,Motasem, AU - Subedar,Asad, AU - Chiu,Thomas, AU - Wludyka,Peter, AU - Rathore,Mobeen, PY - 2006/12/14/pubmed PY - 2007/3/16/medline PY - 2006/12/14/entrez SP - 45 EP - 52 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 46 IS - 1 N2 - The authors investigated the impact of heptavalent pneumococcal conjugate vaccine (PCV7) shortage on the rate of invasive pneumococcal disease (IPD). Vaccination status and number of doses delivered was determined. Regression analysis using an exponential decay model was used to predict the expected rate of IPD in the shortage period if IPD continued to decline at the same rate as in the availability period. The rate of IPD decreased from 15.5 to 6.5 with vaccine availability (P < .00001) and increased to 7.2 with shortage (P = .69). Based on the model, IPD rate would have been 3.6 if the decrease continued at the same rate when there was no shortage; this was statistically significant (95% prediction interval, 2.7-4.1). The rate of IPD correlated directly with the number of PCV7 doses delivered, r = -.98. Continuous availability of the PCV7 would have resulted in a statistically significant lower IPD rate compared to the measured IPD rate in the vaccine shortage period. SN - 0009-9228 UR - https://www.unboundmedicine.com/medline/citation/17164509/Increase_in_invasive_pneumococcal_disease_in_children_associated_with_shortage_of_heptavalent_pneumococcal_conjugate_vaccine_ L2 - https://journals.sagepub.com/doi/10.1177/0009922806289322?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -