Tags

Type your tag names separated by a space and hit enter

Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection.
J Pediatr Hematol Oncol 2006; 28(12):809-15JP

Abstract

OBJECTIVES

To know the variations of serum transferrin receptor (sTfR) and its indices depending on the status of body iron and the presence of infection in children, to evaluate their usefulness for recognizing the nature of anemia in infection, and to know the role of erythropoietic activity in these conditions.

DESIGN AND METHODS

Three hundred and sixty-eight children between 1 and 10 years were included: 206 healthy children; 60 iron deficient anemic children (IDA); 102 with anemia and infectious disease, 58 of them meeting criteria for IDA. We measured hemoglobin, red cell indices, reticulocytes, transferrin saturation, serum ferritin, erythrocyte protoporphyrin, serum erythropoietin, and sTfR. Statistic method: ANOVA test, multiple linear regression, and ROC curve.

RESULTS

sTfR, sTfR/ferritin ratio, and sTfR-logferritin index values were found to increase significantly in IDA children. These values were significantly lower in infectious anemia than iron deficiency states. Serum erythropoietin only was elevated significantly in iron deficiency states. In children without infection, mean corpuscular hemoglobin, erythrocyte protoporphirin, erythropoietin logarithm, and total-iron-binding-capacity logarithm predicted 81% of sTfR variability. sTfR and its indices showed a very high sensitivity and specificity for recognizing iron deficiency states. In children with IDA and infection sensitivity for sTfR/ferritin ratio was low (area under the curve: 0.71; 95% confidence interval: 0.64-0.88). For discriminating the nature of anemia in infection the cut-off point obtained for sTfR, sTfR/ferritin ratio, and sTfR-F index were 3, 70, and 1.8, respectively, and their sensitivity and specificity were also very high.

CONCLUSIONS

sTfR, sTfR/ferritin ratio, and sTfR-F index are useful parameters for recognizing iron deficiency and the nature of anemia in infection. In IDA+infection, sTfR/ferritin ratio should not be recommended in the diagnosis of iron deficiency. In iron deficiency, erythropoietic activity has a secondary role as predictor factor of sTfR levels.

Authors+Show Affiliations

Departments of Pediatrics, Hospital Torrecárdenas, Almería, Spain. mavazquezl@cajamar.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17164650

Citation

Angeles Vázquez López, M, et al. "Serum Transferrin Receptor in Children: Usefulness for Determinating the Nature of Anemia in Infection." Journal of Pediatric Hematology/oncology, vol. 28, no. 12, 2006, pp. 809-15.
Angeles Vázquez López M, Molinos FL, Carmona ML, et al. Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection. J Pediatr Hematol Oncol. 2006;28(12):809-15.
Angeles Vázquez López, M., Molinos, F. L., Carmona, M. L., Morales, A. C., Muñoz Vico, F. J., Muñoz, J. L., & Muñoz Hoyos, A. (2006). Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection. Journal of Pediatric Hematology/oncology, 28(12), pp. 809-15.
Angeles Vázquez López M, et al. Serum Transferrin Receptor in Children: Usefulness for Determinating the Nature of Anemia in Infection. J Pediatr Hematol Oncol. 2006;28(12):809-15. PubMed PMID: 17164650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection. AU - Angeles Vázquez López,M, AU - Molinos,Francisco Lendinez, AU - Carmona,Moisés Leyva, AU - Morales,Amparo Carracedo, AU - Muñoz Vico,Francisco Javier, AU - Muñoz,Juan López, AU - Muñoz Hoyos,Antonio, PY - 2006/12/14/pubmed PY - 2007/1/26/medline PY - 2006/12/14/entrez SP - 809 EP - 15 JF - Journal of pediatric hematology/oncology JO - J. Pediatr. Hematol. Oncol. VL - 28 IS - 12 N2 - OBJECTIVES: To know the variations of serum transferrin receptor (sTfR) and its indices depending on the status of body iron and the presence of infection in children, to evaluate their usefulness for recognizing the nature of anemia in infection, and to know the role of erythropoietic activity in these conditions. DESIGN AND METHODS: Three hundred and sixty-eight children between 1 and 10 years were included: 206 healthy children; 60 iron deficient anemic children (IDA); 102 with anemia and infectious disease, 58 of them meeting criteria for IDA. We measured hemoglobin, red cell indices, reticulocytes, transferrin saturation, serum ferritin, erythrocyte protoporphyrin, serum erythropoietin, and sTfR. Statistic method: ANOVA test, multiple linear regression, and ROC curve. RESULTS: sTfR, sTfR/ferritin ratio, and sTfR-logferritin index values were found to increase significantly in IDA children. These values were significantly lower in infectious anemia than iron deficiency states. Serum erythropoietin only was elevated significantly in iron deficiency states. In children without infection, mean corpuscular hemoglobin, erythrocyte protoporphirin, erythropoietin logarithm, and total-iron-binding-capacity logarithm predicted 81% of sTfR variability. sTfR and its indices showed a very high sensitivity and specificity for recognizing iron deficiency states. In children with IDA and infection sensitivity for sTfR/ferritin ratio was low (area under the curve: 0.71; 95% confidence interval: 0.64-0.88). For discriminating the nature of anemia in infection the cut-off point obtained for sTfR, sTfR/ferritin ratio, and sTfR-F index were 3, 70, and 1.8, respectively, and their sensitivity and specificity were also very high. CONCLUSIONS: sTfR, sTfR/ferritin ratio, and sTfR-F index are useful parameters for recognizing iron deficiency and the nature of anemia in infection. In IDA+infection, sTfR/ferritin ratio should not be recommended in the diagnosis of iron deficiency. In iron deficiency, erythropoietic activity has a secondary role as predictor factor of sTfR levels. SN - 1077-4114 UR - https://www.unboundmedicine.com/medline/citation/17164650/Serum_transferrin_receptor_in_children:_usefulness_for_determinating_the_nature_of_anemia_in_infection_ L2 - http://Insights.ovid.com/pubmed?pmid=17164650 DB - PRIME DP - Unbound Medicine ER -