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High plasma leptin predicts an increase in subcutaneous adiposity in children and adults.
Eur J Clin Nutr. 2007 Jun; 61(6):719-26.EJ

Abstract

OBJECTIVE

To investigate the hypothesis that plasma leptin may predict adiposity changes.

DESIGN

A population-based cohort study.

SETTING

Fleurbaix and Laventie, in the north of France.

SUBJECTS

In all, 1175 subjects participated, of whom 946 completed measurements at baseline (1999) and follow-up (2001). After excluding 64 subjects obese at baseline, 882 subjects (478 adults, 404 children 8 years and over) were included in the analysis.

INTERVENTIONS

We measured plasma leptin concentrations at baseline and various adiposity parameters at baseline and follow-up. Partial correlation coefficients (r(p)) between baseline plasma leptin and each adiposity indicator at follow-up were calculated with adjustment for baseline age, pubertal stage, adiposity and familial correlations between siblings.

RESULTS

Changes in body mass index and percentage body fat were not related to baseline plasma leptin. High baseline plasma leptin predicted an increase (r(p) (P-value)) in the sum of the four skinfolds (0.18 (<0.0001)), the waist circumference (0.16 (0.0003)) and the waist-to-hip ratio (0.29 (<0.0001)) in adults only, and in the hip circumference in adults (0.20 (<0.0001)) and children (0.22 (<0.0001)). After adjustment for a set of four adiposity variables at baseline (percentage body fat, skinfolds, waist and hip circumferences), baseline plasma leptin predicted only changes in the sum of the four skinfolds in adults (0.15 (0.001)), with similar tendency although not significant in children (0.08 (0.13)).

CONCLUSIONS

A high leptin relative to baseline fat mass predicts fat mass gain over time, mainly in the subcutaneous location.

Authors+Show Affiliations

INSERM U 780, IFR 69, Faculté de Médecine Paris-Sud, Villejuif, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17164827

Citation

Kettaneh, A, et al. "High Plasma Leptin Predicts an Increase in Subcutaneous Adiposity in Children and Adults." European Journal of Clinical Nutrition, vol. 61, no. 6, 2007, pp. 719-26.
Kettaneh A, Heude B, Romon M, et al. High plasma leptin predicts an increase in subcutaneous adiposity in children and adults. Eur J Clin Nutr. 2007;61(6):719-26.
Kettaneh, A., Heude, B., Romon, M., Oppert, J. M., Borys, J. M., Balkau, B., Ducimetière, P., & Charles, M. A. (2007). High plasma leptin predicts an increase in subcutaneous adiposity in children and adults. European Journal of Clinical Nutrition, 61(6), 719-26.
Kettaneh A, et al. High Plasma Leptin Predicts an Increase in Subcutaneous Adiposity in Children and Adults. Eur J Clin Nutr. 2007;61(6):719-26. PubMed PMID: 17164827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma leptin predicts an increase in subcutaneous adiposity in children and adults. AU - Kettaneh,A, AU - Heude,B, AU - Romon,M, AU - Oppert,J M, AU - Borys,J M, AU - Balkau,B, AU - Ducimetière,P, AU - Charles,M A, Y1 - 2006/12/13/ PY - 2006/12/14/pubmed PY - 2007/7/10/medline PY - 2006/12/14/entrez SP - 719 EP - 26 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 6 N2 - OBJECTIVE: To investigate the hypothesis that plasma leptin may predict adiposity changes. DESIGN: A population-based cohort study. SETTING: Fleurbaix and Laventie, in the north of France. SUBJECTS: In all, 1175 subjects participated, of whom 946 completed measurements at baseline (1999) and follow-up (2001). After excluding 64 subjects obese at baseline, 882 subjects (478 adults, 404 children 8 years and over) were included in the analysis. INTERVENTIONS: We measured plasma leptin concentrations at baseline and various adiposity parameters at baseline and follow-up. Partial correlation coefficients (r(p)) between baseline plasma leptin and each adiposity indicator at follow-up were calculated with adjustment for baseline age, pubertal stage, adiposity and familial correlations between siblings. RESULTS: Changes in body mass index and percentage body fat were not related to baseline plasma leptin. High baseline plasma leptin predicted an increase (r(p) (P-value)) in the sum of the four skinfolds (0.18 (<0.0001)), the waist circumference (0.16 (0.0003)) and the waist-to-hip ratio (0.29 (<0.0001)) in adults only, and in the hip circumference in adults (0.20 (<0.0001)) and children (0.22 (<0.0001)). After adjustment for a set of four adiposity variables at baseline (percentage body fat, skinfolds, waist and hip circumferences), baseline plasma leptin predicted only changes in the sum of the four skinfolds in adults (0.15 (0.001)), with similar tendency although not significant in children (0.08 (0.13)). CONCLUSIONS: A high leptin relative to baseline fat mass predicts fat mass gain over time, mainly in the subcutaneous location. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17164827/High_plasma_leptin_predicts_an_increase_in_subcutaneous_adiposity_in_children_and_adults_ L2 - https://doi.org/10.1038/sj.ejcn.1602579 DB - PRIME DP - Unbound Medicine ER -