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Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients.

Abstract

OBJECTIVE

Aortic stiffness and wave reflections are important markers and prognosticators of cardiovascular risk. Caffeine increases acutely aortic stiffness and wave reflections. Furthermore, chronic coffee consumption is associated with increased aortic stiffness and wave reflections in normotensive subjects. In the present study, we aimed to assess the association between chronic coffee consumption, and aortic stiffness and wave reflections in hypertensive patients.

DESIGN

Epidemiological survey.

SETTING

Hypertension Unit, University Hospital. SUBJECTS-METHODS: We examined 259 never-treated hypertensives (age 50+/-12 years, 165 males) without diabetes mellitus, who were asked to describe in detail the type and amount of coffee they consumed. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) were measured non-invasively as indices of aortic stiffness and wave reflections, respectively.

RESULTS

When controlled for gender, age, height, smoking status, heart rate, mean pressure, HDL cholesterol and hsCRP, AIx was found to be higher with increasing daily coffee consumption. Post hoc analysis revealed that all groups of coffee consumption had higher AIx compared to no-consumption. PWV did not differ among groups of daily coffee consumption. Each participant had 35% higher relative risk of having high AIx for each cup (150 ml) of coffee per day, and 40% higher relative risk for each 10 cup-years.

CONCLUSIONS

Coffee consumption is associated with increased wave reflections, but not aortic stiffness in never-treated hypertensive patients. This finding may have important clinical implications for cardiovascular health in hypertensive subjects.

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  • Authors+Show Affiliations

    ,

    Hypertension Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece. cvlachop@otenet.gr

    , , , , ,

    Source

    MeSH

    Aorta
    Aortic Diseases
    Blood Flow Velocity
    Blood Pressure
    Caffeine
    Central Nervous System Stimulants
    Coffee
    Elasticity
    Female
    Humans
    Hypertension
    Male
    Middle Aged
    Pulsatile Flow

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17164828

    Citation

    Vlachopoulos, C V., et al. "Effect of Chronic Coffee Consumption On Aortic Stiffness and Wave Reflections in Hypertensive Patients." European Journal of Clinical Nutrition, vol. 61, no. 6, 2007, pp. 796-802.
    Vlachopoulos CV, Vyssoulis GG, Alexopoulos NA, et al. Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients. Eur J Clin Nutr. 2007;61(6):796-802.
    Vlachopoulos, C. V., Vyssoulis, G. G., Alexopoulos, N. A., Zervoudaki, A. I., Pietri, P. G., Aznaouridis, K. A., & Stefanadis, C. I. (2007). Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients. European Journal of Clinical Nutrition, 61(6), pp. 796-802.
    Vlachopoulos CV, et al. Effect of Chronic Coffee Consumption On Aortic Stiffness and Wave Reflections in Hypertensive Patients. Eur J Clin Nutr. 2007;61(6):796-802. PubMed PMID: 17164828.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients. AU - Vlachopoulos,C V, AU - Vyssoulis,G G, AU - Alexopoulos,N A, AU - Zervoudaki,A I, AU - Pietri,P G, AU - Aznaouridis,K A, AU - Stefanadis,C I, Y1 - 2006/12/13/ PY - 2006/12/14/pubmed PY - 2007/7/10/medline PY - 2006/12/14/entrez SP - 796 EP - 802 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 6 N2 - OBJECTIVE: Aortic stiffness and wave reflections are important markers and prognosticators of cardiovascular risk. Caffeine increases acutely aortic stiffness and wave reflections. Furthermore, chronic coffee consumption is associated with increased aortic stiffness and wave reflections in normotensive subjects. In the present study, we aimed to assess the association between chronic coffee consumption, and aortic stiffness and wave reflections in hypertensive patients. DESIGN: Epidemiological survey. SETTING: Hypertension Unit, University Hospital. SUBJECTS-METHODS: We examined 259 never-treated hypertensives (age 50+/-12 years, 165 males) without diabetes mellitus, who were asked to describe in detail the type and amount of coffee they consumed. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) were measured non-invasively as indices of aortic stiffness and wave reflections, respectively. RESULTS: When controlled for gender, age, height, smoking status, heart rate, mean pressure, HDL cholesterol and hsCRP, AIx was found to be higher with increasing daily coffee consumption. Post hoc analysis revealed that all groups of coffee consumption had higher AIx compared to no-consumption. PWV did not differ among groups of daily coffee consumption. Each participant had 35% higher relative risk of having high AIx for each cup (150 ml) of coffee per day, and 40% higher relative risk for each 10 cup-years. CONCLUSIONS: Coffee consumption is associated with increased wave reflections, but not aortic stiffness in never-treated hypertensive patients. This finding may have important clinical implications for cardiovascular health in hypertensive subjects. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17164828/Effect_of_chronic_coffee_consumption_on_aortic_stiffness_and_wave_reflections_in_hypertensive_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602577 DB - PRIME DP - Unbound Medicine ER -