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Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin.
Eur J Nutr 2007; 46(1):53-6EJ

Abstract

BACKGROUND

Long term cocoa ingestion leads to an increased resistance against UV-induced erythema and a lowered transepidermal water loss.

AIM OF THE STUDY

To investigate the acute effects of a single dose of cocoa rich in flavanols on dermal microcirculation.

METHODS

In a crossover design study, 10 healthy women ingested a cocoa drink (100 ml) with high (329 mg) or low (27 mg) content of flavanols. The major flavanol monomer in both drinks was epicatechin, 61 mg in the high flavanol, and 6.6 mg in the low flavanol product per 100 ml. Dermal blood flow and oxygen saturation of hemoglobin were examined by laser Doppler flowmetry and spectroscopically at 1 mm skin depth at t = 0, 1, 2, 4, and 6 h. At the same time points, plasma levels of total epicatechin (free compound plus conjugates) were measured by means of HPLC.

RESULTS

Subsequent to the intake of high flavanol cocoa, dermal blood flow was significantly increased by 1.7-fold at t = 2 h and oxygen saturation was elevated 1.8-fold. No statistically significant changes were found upon intake of low flavanol cocoa. Maximum plasma levels of total epicatechin were observed 1 h after ingestion of the high flavanol cocoa drink, 11.6 +/- 7.4 nmol/l at baseline, and 62.9 +/- 35.8 nmol/l at 1 h. No change of total epicatechin was found in the low flavanol group.

CONCLUSION

Flavanol-rich cocoa consumption acutely increases dermal blood flow and oxygen saturation.

Authors+Show Affiliations

Institut für Biochemie und Molekularbiologie I, Heinrich-Heine-Universität Düsseldorf, P.O. Box 101007, 40001 Dusseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17164979

Citation

Neukam, Karin, et al. "Consumption of Flavanol-rich Cocoa Acutely Increases Microcirculation in Human Skin." European Journal of Nutrition, vol. 46, no. 1, 2007, pp. 53-6.
Neukam K, Stahl W, Tronnier H, et al. Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr. 2007;46(1):53-6.
Neukam, K., Stahl, W., Tronnier, H., Sies, H., & Heinrich, U. (2007). Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. European Journal of Nutrition, 46(1), pp. 53-6.
Neukam K, et al. Consumption of Flavanol-rich Cocoa Acutely Increases Microcirculation in Human Skin. Eur J Nutr. 2007;46(1):53-6. PubMed PMID: 17164979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. AU - Neukam,Karin, AU - Stahl,Wilhelm, AU - Tronnier,Hagen, AU - Sies,Helmut, AU - Heinrich,Ulrike, Y1 - 2006/12/11/ PY - 2006/06/02/received PY - 2006/10/27/accepted PY - 2006/12/14/pubmed PY - 2007/10/12/medline PY - 2006/12/14/entrez SP - 53 EP - 6 JF - European journal of nutrition JO - Eur J Nutr VL - 46 IS - 1 N2 - BACKGROUND: Long term cocoa ingestion leads to an increased resistance against UV-induced erythema and a lowered transepidermal water loss. AIM OF THE STUDY: To investigate the acute effects of a single dose of cocoa rich in flavanols on dermal microcirculation. METHODS: In a crossover design study, 10 healthy women ingested a cocoa drink (100 ml) with high (329 mg) or low (27 mg) content of flavanols. The major flavanol monomer in both drinks was epicatechin, 61 mg in the high flavanol, and 6.6 mg in the low flavanol product per 100 ml. Dermal blood flow and oxygen saturation of hemoglobin were examined by laser Doppler flowmetry and spectroscopically at 1 mm skin depth at t = 0, 1, 2, 4, and 6 h. At the same time points, plasma levels of total epicatechin (free compound plus conjugates) were measured by means of HPLC. RESULTS: Subsequent to the intake of high flavanol cocoa, dermal blood flow was significantly increased by 1.7-fold at t = 2 h and oxygen saturation was elevated 1.8-fold. No statistically significant changes were found upon intake of low flavanol cocoa. Maximum plasma levels of total epicatechin were observed 1 h after ingestion of the high flavanol cocoa drink, 11.6 +/- 7.4 nmol/l at baseline, and 62.9 +/- 35.8 nmol/l at 1 h. No change of total epicatechin was found in the low flavanol group. CONCLUSION: Flavanol-rich cocoa consumption acutely increases dermal blood flow and oxygen saturation. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/17164979/Consumption_of_flavanol_rich_cocoa_acutely_increases_microcirculation_in_human_skin_ L2 - https://dx.doi.org/10.1007/s00394-006-0627-6 DB - PRIME DP - Unbound Medicine ER -