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[Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases].
Ai Zheng. 2006 Dec; 25(12):1529-32.AZ

Abstract

BACKGROUND & OBJECTIVE

The overall survival rate of children and adolescents with germ cell tumor is more than 75% after adopting combined therapy. However, the prognosis varies with stage, pathologic type, and primary tumor site. This study was to analyze the clinical characteristics and treatment outcome of children and adolescents with germ cell tumor, and to investigate the prognostic factors and therapeutic strategy.

METHODS

Clinical characteristics, treatment outcome, and prognostic factors of 44 children and adolescents with germ cell tumor, treated in Cancer Center of Sun Yat-sen University from Jan. 1997 to Dec. 2005, were analyzed. Survival rate was calculated by Kaplan-Meier method.

RESULTS

Of the 44 patients, 25 received adjuvant chemotherapy after operation; 1 received operation alone; 18 received induction chemotherapy. Of the 18 patients, 7 received tumor resection after chemotherapy; 2 patients with primary mediastinal chorioepithelioma with multiple metastases received radiotherapy on residual disease after chemotherapy; 1 patient with postoperative abdominal metastasis and 1 with postoperative lung metastasis achieved complete remission after chemotherapy; 1 patient with mediastinal sinus tumor achieved partial remission after chemotherapy; 6 had poor response to chemotherapy and died of disease progression. Chemotherapy-treated patients received platinum-containing regimens for 2-7 cycles. The median follow-up was 32 months. The overall 3-year survival rate was 84.8%. The 3-year survival rate was 100% for stage I-II patients, 83.3% for stage III patients, 65.6% for stage IV patients, and 66.7% for relapsed patients. For previously untreated patients, the 3-year survival rate was 96.0% for gonadal germ cell tumor patients and 61.0% for extragonadal germ cell tumor patients.

CONCLUSION

Surgery combined with platinum-containing chemotherapy can improve efficacy and survival of children and adolescents with germ cell tumor. For the patients with stage IV, relapsed, and metastatic tumors, novel therapeutic regimens with increased dose intensity need further investigation.

Authors+Show Affiliations

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. gzsunxf@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17166380

Citation

Sun, Xiao-Fei, et al. "[Treatment Outcome of Children and Adolescents With Germ Cell Tumor After Combined Therapy---a Report of 44 Cases]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 25, no. 12, 2006, pp. 1529-32.
Sun XF, Yang QY, Zhen ZJ, et al. [Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases]. Ai Zheng. 2006;25(12):1529-32.
Sun, X. F., Yang, Q. Y., Zhen, Z. J., Xia, Y., Huang, Z. H., & Ling, J. Y. (2006). [Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 25(12), 1529-32.
Sun XF, et al. [Treatment Outcome of Children and Adolescents With Germ Cell Tumor After Combined Therapy---a Report of 44 Cases]. Ai Zheng. 2006;25(12):1529-32. PubMed PMID: 17166380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases]. AU - Sun,Xiao-Fei, AU - Yang,Qun-Ying, AU - Zhen,Zi-Jun, AU - Xia,Yi, AU - Huang,Zhi-Hui, AU - Ling,Jia-Yu, PY - 2006/12/15/pubmed PY - 2009/6/10/medline PY - 2006/12/15/entrez SP - 1529 EP - 32 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 25 IS - 12 N2 - BACKGROUND & OBJECTIVE: The overall survival rate of children and adolescents with germ cell tumor is more than 75% after adopting combined therapy. However, the prognosis varies with stage, pathologic type, and primary tumor site. This study was to analyze the clinical characteristics and treatment outcome of children and adolescents with germ cell tumor, and to investigate the prognostic factors and therapeutic strategy. METHODS: Clinical characteristics, treatment outcome, and prognostic factors of 44 children and adolescents with germ cell tumor, treated in Cancer Center of Sun Yat-sen University from Jan. 1997 to Dec. 2005, were analyzed. Survival rate was calculated by Kaplan-Meier method. RESULTS: Of the 44 patients, 25 received adjuvant chemotherapy after operation; 1 received operation alone; 18 received induction chemotherapy. Of the 18 patients, 7 received tumor resection after chemotherapy; 2 patients with primary mediastinal chorioepithelioma with multiple metastases received radiotherapy on residual disease after chemotherapy; 1 patient with postoperative abdominal metastasis and 1 with postoperative lung metastasis achieved complete remission after chemotherapy; 1 patient with mediastinal sinus tumor achieved partial remission after chemotherapy; 6 had poor response to chemotherapy and died of disease progression. Chemotherapy-treated patients received platinum-containing regimens for 2-7 cycles. The median follow-up was 32 months. The overall 3-year survival rate was 84.8%. The 3-year survival rate was 100% for stage I-II patients, 83.3% for stage III patients, 65.6% for stage IV patients, and 66.7% for relapsed patients. For previously untreated patients, the 3-year survival rate was 96.0% for gonadal germ cell tumor patients and 61.0% for extragonadal germ cell tumor patients. CONCLUSION: Surgery combined with platinum-containing chemotherapy can improve efficacy and survival of children and adolescents with germ cell tumor. For the patients with stage IV, relapsed, and metastatic tumors, novel therapeutic regimens with increased dose intensity need further investigation. UR - https://www.unboundmedicine.com/medline/citation/17166380/[Treatment_outcome_of_children_and_adolescents_with_germ_cell_tumor_after_combined_therapy___a_report_of_44_cases]_ L2 - http://www.cancercommun.com/fulltextnew.asp?y=2006&m=12&ym=1529 DB - PRIME DP - Unbound Medicine ER -